{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:55:08Z","timestamp":1760234108971,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010409","name":"Children's Investment Fund Foundation","doi-asserted-by":"publisher","award":["CMAM 2.0: Reinventing community management of acute malnutrition"],"award-info":[{"award-number":["CMAM 2.0: Reinventing community management of acute malnutrition"]}],"id":[{"id":"10.13039\/100010409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["AID-OFDA-G-14-00208"],"award-info":[{"award-number":["AID-OFDA-G-14-00208"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Weight-for-age z-score (WAZ) is not currently an admission criterion to therapeutic feeding programs, and children with low WAZ at high risk of mortality may not be admitted. We conducted a secondary analysis of RCT data to assess response to treatment according to WAZ and mid-upper arm circumference (MUAC) and type of feeding protocol given: a simplified, combined protocol for severe and moderate acute malnutrition (SAM and MAM) vs. standard care that treats SAM and MAM, separately. Children with a moderately low MUAC (11.5\u201312.5 cm) and a severely low WAZ (&lt;\u22123) respond similarly to treatment in terms of both weight and MUAC gain on either 2092 kJ (500 kcal)\/day of therapeutic or supplementary food. Children with a severely low MUAC (&lt;11.5 cm), with\/without a severely low WAZ (&lt;\u22123), have similar recovery with the combined protocol or standard treatment, though WAZ gain may be slower in the combined protocol. A limitation is this analysis was not powered for these sub-groups specifically. Adding WAZ &lt; \u22123 as an admission criterion for therapeutic feeding programs admitting children with MUAC and\/or oedema may help programs target high-risk children who can benefit from treatment. Future work should evaluate the optimal treatment protocol for children with a MUAC &lt; 11.5 and\/or WAZ &lt; \u22123.0.<\/jats:p>","DOI":"10.3390\/nu13041054","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T21:36:51Z","timestamp":1616621811000},"page":"1054","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Response to Malnutrition Treatment in Low Weight-for-Age Children: Secondary Analyses of Children 6\u201359 Months in the ComPAS Cluster Randomized Controlled Trial"],"prefix":"10.3390","volume":"13","author":[{"given":"Jeanette","family":"Bailey","sequence":"first","affiliation":[{"name":"International Rescue Committee, New York, NY 10168, USA"},{"name":"Department of Population Health, London School of Hygiene &amp; Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-0198","authenticated-orcid":false,"given":"Natasha","family":"Lelijveld","sequence":"additional","affiliation":[{"name":"Emergency Nutrition Network, Oxford OX5 2DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Khara","sequence":"additional","affiliation":[{"name":"Emergency Nutrition Network, Oxford OX5 2DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1130-6948","authenticated-orcid":false,"given":"Carmel","family":"Dolan","sequence":"additional","affiliation":[{"name":"Emergency Nutrition Network, Oxford OX5 2DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Stobaugh","sequence":"additional","affiliation":[{"name":"Action Against Hunger, New York, NY 10004, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Sadler","sequence":"additional","affiliation":[{"name":"Emergency Nutrition Network, Oxford OX5 2DN, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Lino Lako","sequence":"additional","affiliation":[{"name":"Department of Policy, Planning, Budgeting and Research, Ministry of Health, Juba, South Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9390-8541","authenticated-orcid":false,"given":"Andr\u00e9","family":"Briend","sequence":"additional","affiliation":[{"name":"Center for Child Health Research, Faculty of Medicine and Health Technology, Tampere University, FI-33014 Tampere, Finland"},{"name":"Department of Nutrition, Exercise and Sports, University of Copenhagen, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Opondo","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, London School of Hygiene &amp; Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3745-7317","authenticated-orcid":false,"given":"Marko","family":"Kerac","sequence":"additional","affiliation":[{"name":"Department of Population Health, London School of Hygiene &amp; Tropical Medicine, London WC1E 7HT, UK"},{"name":"Centre for Maternal, Adolescent, Reproductive, &amp; Child Health, London School of Hygiene &amp; Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1119-1474","authenticated-orcid":false,"given":"Mark","family":"Myatt","sequence":"additional","affiliation":[{"name":"Brixton Health, Llwyngwril, Gwynedd LL37 2JD, Wales, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(13)60937-X","article-title":"Maternal and child undernutrition and overweight in low-income and middle-income countries","volume":"382","author":"Black","year":"2013","journal-title":"Lancet"},{"key":"ref_2","unstructured":"UNICEF, World Health Organization, and World Bank Group (2021, March 22). 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