{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:48:38Z","timestamp":1790362118026,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Background: Hypertriglyceridemia (HiTG) is a metabolic complication of intravenous lipid emulsions (ILEs) infusion. We aimed to evaluate the influence of HiTG on the respiratory outcome of preterm babies; (2) Methods: We enrolled, in a case\u2013control study, newborns with gestational age &lt;32 weeks or birth weight &lt;1500 g, over a 3-year period. They were divided into cases and controls; cases were defined by the detection of HiTG defined as serum triglycerides (TG) value &gt;150 mg\/dL; (3) Results: We enrolled 40 cases and 105 controls. Cases had an increased incidence of bronchopulmonary dysplasia (30.0% vs. 14.3%, p &lt; 0.05) and longer duration of invasive mechanical ventilation (7 days, 95% CI 4\u201310 days vs. 4 days, 95% CI 1\u20137 days, p &lt; 0.01) compared to controls. Multivariate analysis confirmed that HiTG independently influenced the duration of invasive mechanical ventilation, also in the subgroups with gestational age \u226428 + 6\/7 weeks or birth weight \u22641000 g; (4) Conclusion: Newborns with HiTG related to ILEs had a longer duration of invasive mechanical ventilation. Temporary suspension or reduction in ILEs in the case of HiTG is associated with an improvement of respiratory outcome.<\/jats:p>","DOI":"10.3390\/nu13041243","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T05:52:00Z","timestamp":1618206720000},"page":"1243","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2481-0692","authenticated-orcid":false,"given":"Giovanni","family":"Boscarino","sequence":"first","affiliation":[{"name":"Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8659-4652","authenticated-orcid":false,"given":"Maria Giulia","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy"},{"name":"Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Di Chiara","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Deli","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Favata","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Cardilli","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-7758","authenticated-orcid":false,"given":"Giovanni","family":"Di Nardo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mental Health &amp; Sense Organs (NESMOS), Faculty of Medicine &amp; Psychology, c\/o Sant\u2019 Andrea Hospital, Sapienza University, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-8120","authenticated-orcid":false,"given":"Pasquale","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mental Health &amp; Sense Organs (NESMOS), Faculty of Medicine &amp; Psychology, c\/o Sant\u2019 Andrea Hospital, Sapienza University, 00189 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-2876","authenticated-orcid":false,"given":"Gianluca","family":"Terrin","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Policlinico Umberto I Hospital, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/j.clnu.2018.06.944","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN Guidelines on Pediatric Parenteral Nutrition: Energy","volume":"37","author":"Joosten","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.clnu.2018.06.946","article-title":"ESPGHAN\/ESPEN\/ESPR\/CSPEN Guidelines on Pediatric Parenteral Nutrition: Lipids","volume":"37","author":"Lapillonne","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Terrin, G., Coscia, A., Boscarino, G., Faccioli, F., Di Chiara, M., Greco, C., Onest\u00e0, E., Oliva, S., Aloi, M., and Dito, L. (2020). Long-Term Effects on Growth of an Energy-Enhanced Parenteral Nutrition in Preterm Newborn: A Quasi-Experimental Study. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0235540"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/jamapediatrics.2015.1667","article-title":"Early Enhanced Parenteral Nutrition, Hyperglycemia, and Death Among Extremely Low-Birth-Weight Infants","volume":"169","author":"Stensvold","year":"2015","journal-title":"JAMA Pediatr."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Terrin, G., Boscarino, G., Gasparini, C., Chiara, M.D., Faccioli, F., Onest\u00e0, E., Parisi, P., Spalice, A., De Nardo, M.C., and Dito, L. (2021). Energy-Enhanced Parenteral Nutrition and Neurodevelopment of Preterm Newborns: A Cohort Study. Nutrition, 111219.","DOI":"10.1016\/j.nut.2021.111219"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bonsante, F., Gouyon, J.-B., Robillard, P.-Y., Gouyon, B., and Iacobelli, S. (2017). Early Optimal Parenteral Nutrition and Metabolic Acidosis in Very Preterm Infants. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186936"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/j.1536-4801.2005.tb00011.x","article-title":"Guidelines on Paediatric Parenteral Nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), Supported by the European Society of Paediatric Research (ESPR)","volume":"41","author":"Koletzko","year":"2005","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"F95","DOI":"10.1136\/fn.74.2.F95","article-title":"Pulmonary Vascular Resistance during Lipid Infusion in Neonates","volume":"74","author":"Prasertsom","year":"1996","journal-title":"Arch. Dis. Child. Fetal Neonatal Ed."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/adc.66.1_Spec_No.26","article-title":"Pulmonary Intravascular Lipid in Neonatal Necropsy Specimens","volume":"66","author":"Puntis","year":"1991","journal-title":"Arch. Dis. Child."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1542\/peds.78.1.79","article-title":"Fat Emulsion Tolerance in Very Low Birth Weight Neonates: Effect on Diffusion of Oxygen in the Lungs and on Blood PH","volume":"78","author":"Brans","year":"1986","journal-title":"Pediatrics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.3748\/wjg.v16.i21.2664","article-title":"Diarrhea in Neonatal Intensive Care Unit","volume":"16","author":"Passariello","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11894-011-0188-6","article-title":"Recent Progress in Congenital Diarrheal Disorders","volume":"13","author":"Canani","year":"2011","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/B978-0-444-64029-1.00022-9","article-title":"Inborn errors of metabolism","volume":"Volume 162","author":"Ferreira","year":"2019","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.clnu.2015.12.004","article-title":"Cow\u2019s Milk and Rice Fermented with Lactobacillus Paracasei CBA L74 Prevent Infectious Diseases in Children: A Randomized Controlled Trial","volume":"36","author":"Nocerino","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1542\/peds.107.2.416","article-title":"A Case of Protein-Losing Enteropathy Caused by Intestinal Lymphangiectasia in a Preterm Infant","volume":"107","author":"Salvia","year":"2001","journal-title":"Pediatrics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1365-2036.2012.05015.x","article-title":"Randomised Clinical Trial: Efficacy of a New Synbiotic Formulation Containing Lactobacillus Paracasei B21060 plus Arabinogalactan and Xilooligosaccharides in Children with Acute Diarrhoea","volume":"35","author":"Passariello","year":"2012","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"582735","DOI":"10.3389\/fped.2020.582735","article-title":"Echocardiography-Guided Management of Preterms With Patent Ductus Arteriosus Influences the Outcome: A Cohort Study","volume":"8","author":"Terrin","year":"2020","journal-title":"Front. Pediatr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13052-021-00956-2","article-title":"Morbidity Associated with Patent Ductus Arteriosus in Preterm Newborns: A Retrospective Case-Control Study","volume":"47","author":"Terrin","year":"2021","journal-title":"Ital. J. Pediatr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Peila, C., Spada, E., Giuliani, F., Maiocco, G., Raia, M., Cresi, F., Bertino, E., and Coscia, A. (2020). Extrauterine Growth Restriction: Definitions and Predictability of Outcomes in a Cohort of Very Low Birth Weight Infants or Preterm Neonates. Nutrients, 12.","DOI":"10.3390\/nu12051224"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Terrin, G., Boscarino, G., Di Chiara, M., Iacobelli, S., Faccioli, F., Greco, C., Onest\u00e0, E., Sabatini, G., Pietravalle, A., and Oliva, S. (2020). Nutritional Intake Influences Zinc Levels in Preterm Newborns: An Observational Study. Nutrients, 12.","DOI":"10.3390\/nu12020529"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1651-2227.2008.00987.x","article-title":"Minimal Enteral Feeding Reduces the Risk of Sepsis in Feed-Intolerant Very Low Birth Weight Newborns","volume":"98","author":"Terrin","year":"2009","journal-title":"Acta Paediatr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1097\/MCG.0b013e31817da155","article-title":"The Nutritional Modulation of the Evolving Intestine","volume":"42","author":"Passariello","year":"2008","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3389\/fneur.2020.00885","article-title":"Early Protein Intake Influences Neonatal Brain Measurements in Preterms: An Observational Study","volume":"11","author":"Terrin","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1164\/rccm.200305-620OC","article-title":"The Impact of Intravenous Fat Emulsion Administration in Acute Lung Injury","volume":"169","author":"Lekka","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0272-5231(21)00321-X","article-title":"Fat Emulsions and Lung Function","volume":"7","author":"Hageman","year":"1986","journal-title":"Clin. Chest Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1097\/00003246-200108000-00012","article-title":"Effects of Intravenous Fat Emulsions on Lung Function in Patients with Acute Respiratory Distress Syndrome or Sepsis","volume":"29","author":"Suchner","year":"2001","journal-title":"Crit. Care Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1542\/peds.66.1.26","article-title":"Decreased Oxygenation and Hyperlipemia during Intravenous Fat Infusions in Premature Infants","volume":"66","author":"Periera","year":"1980","journal-title":"Pediatrics"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Giretti, I., D\u2019Ascenzo, R., Correani, A., Antognoli, L., Monachesi, C., Biagetti, C., Pompilio, A., Marinelli, L., Burattini, I., and Cogo, P. (2021). Hypertriglyceridemia and Lipid Tolerance in Preterm Infants with a Birth Weight of Less than 1250 g on Routine Parenteral Nutrition. Clin. Nutr. Edinb. Scotl.","DOI":"10.1016\/j.clnu.2020.12.039"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/MPG.0000000000002459","article-title":"Hypertriglyceridemia and Intravenous Lipid Titration During Routine Parenteral Nutrition in Small Preterm Infants","volume":"69","author":"Correani","year":"2019","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Sinclair, R., Schindler, T., Lui, K., and Bolisetty, S. (2018). Hypertriglyceridaemia in Extremely Preterm Infants Receiving Parenteral Lipid Emulsions. BMC Pediatr., 18.","DOI":"10.1186\/s12887-018-1325-2"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3233\/NPM-15814099","article-title":"Hypertriglyceridemia in Extremely Low Birth Weight Infants Receiving Lipid Emulsions","volume":"8","author":"Holtrop","year":"2015","journal-title":"J. Neonatal-Perinat. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1001\/archpedi.1995.02170240067010","article-title":"Lipid Intolerance in Newborns Is Associated with Hepatic Dysfunction but Not Infection","volume":"149","author":"Toce","year":"1995","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"ref_33","first-page":"71","article-title":"Intravenous Lipids in Preterm Infants: Impact on Laboratory and Clinical Outcomes and Long-Term Consequences","volume":"Volume 112","author":"Calder","year":"2014","journal-title":"World Review of Nutrition and Dietetics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.clnesp.2017.08.007","article-title":"Parenteral Nutrition-Associated Cholestasis and Triglyceridemia in Surgical Term and near-Term Neonates: A Pilot Randomized Controlled Trial of Two Mixed Intravenous Lipid Emulsions","volume":"22","author":"Rosa","year":"2017","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.clnu.2018.06.929","article-title":"Intravenous Fish Oil Containing Lipid Emulsion Attenuates Inflammatory Cytokines and the Development of Bronchopulmonary Dysplasia in Very Premature Infants: A Double-Blind, Randomized Controlled Trial","volume":"38","author":"Hsiao","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1177\/0884533613507285","article-title":"The Effect of Parenteral Lipid Emulsions on Pulmonary Hemodynamics and Eicosanoid Metabolites in Preterm Infants: A Pilot Study","volume":"28","author":"Vasudevan","year":"2013","journal-title":"Nutr. Clin. Pract."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/4\/1243\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:12:15Z","timestamp":1760364735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/4\/1243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,9]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["nu13041243"],"URL":"https:\/\/doi.org\/10.3390\/nu13041243","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,9]]}}}