{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:49Z","timestamp":1787029189110,"version":"build-2736575974"},"reference-count":49,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Patients with cirrhosis often develop malnutrition and micronutrient deficiencies, leading to a worse prognosis and increased mortality. Our main goal was to assess the prevalence of micronutrient deficiencies in patients with decompensated cirrhosis. This was a prospective single-center study including 125 consecutive patients hospitalized for acute decompensation of cirrhosis (mostly of alcoholic etiology). A blood test including trace elements and vitamins was performed on admission. The main micronutrient deficiencies observed were vitamin D (in 94.5%), vitamin A (93.5%), vitamin B6 (60.8%) and zinc (85.6%). Patients in Child-Pugh class C had lower levels of vitamin A (p &lt; 0.0001), vitamin E (p = 0.01) and zinc (p &lt; 0.001), and higher levels of ferritin (p = 0.002) and vitamin B12 (p &lt; 0.001) than those in Child-Pugh class A and B. Patients with a higher model of end-stage liver disease (MELD) score had lower levels of vitamin A (p &lt; 0.0001), vitamin E (p &lt; 0.001), magnesium (p = 0.01) and zinc (p = 0.001), and higher levels of ferritin (p = 0.002) and vitamin B12 (p &lt; 0.0001). Severe hepatic insufficiency correlated with lower levels of zinc, vitamin E and vitamin A, and higher levels of vitamin B12 and ferritin.<\/jats:p>","DOI":"10.3390\/nu13041249","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T05:52:00Z","timestamp":1618206720000},"page":"1249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Micronutrient Deficiencies in Patients with Decompensated Liver Cirrhosis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5132-7623","authenticated-orcid":false,"given":"Gemma","family":"Llibre-Nieto","sequence":"first","affiliation":[{"name":"Hepatology Unit, Digestive Disease Department, Hospital Universitari Parc Tauli, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), 08208 Sabadell, Spain"},{"name":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"Fundaci\u00f3 Privada Hospital Assil de Granollers, 08402 Granollers, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Lira","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Digestive Disease Department, Hospital Universitari Parc Tauli, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), 08208 Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-8657","authenticated-orcid":false,"given":"Mercedes","family":"Vergara","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Digestive Disease Department, Hospital Universitari Parc Tauli, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), 08208 Sabadell, Spain"},{"name":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Sol\u00e9","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Digestive Disease Department, Hospital Universitari Parc Tauli, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), 08208 Sabadell, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Casas","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Digestive Disease Department, Hospital Universitari Parc Tauli, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), 08208 Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valent\u00ed","family":"Puig-Div\u00ed","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Digestive Disease Department, Hospital Universitari Parc Tauli, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), 08208 Sabadell, Spain"},{"name":"Gastroenterology Unit, Digestive Disease Department, Hospital Universitari Parc Tauli, Institut d\u2019Investigacio i Innovaci\u00f3 Parc Taul\u00ed (I3PT), 08208 Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Sol\u00e9","sequence":"additional","affiliation":[{"name":"Laboratory Unit, Hospital Universitari Parc Tauli, Institut d\u2019Investigacio i Innovaci\u00f3 Parc Taul\u00ed (I3PT), 08208 Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Humanes","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital 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Spain"},{"name":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Departament de Medicina, Universitat de Vic\u2013Universitat Central de Catalunya (UVic-UCC), 08500 Vic, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5217-6492","authenticated-orcid":false,"given":"Jordi","family":"S\u00e1nchez-Delgado","sequence":"additional","affiliation":[{"name":"Hepatology Unit, Digestive Disease Department, Hospital Universitari Parc Tauli, Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT), 08208 Sabadell, Spain"},{"name":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y 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