{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:59:14Z","timestamp":1792094354703,"version":"4.4.0"},"reference-count":53,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T00:00:00Z","timestamp":1618099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The meta-analysis presented in this article covered the efficacy of red clover isoflavones in relieving hot flushes and menopausal symptoms in perimenopausal and postmenopausal women. Studies were identified by MEDLINE (PubMed), Embase, and the Cochrane Library searches. The quality of the studies was evaluated according to Cochrane criteria. A meta-analysis of eight trials (ten comparisons) demonstrated a statistically significant reduction in the daily incidence of hot flushes in women receiving red clover compared to those receiving placebo: weighted mean difference (WMD\u2014weighted mean difference) \u22121.73 hot flushes per day, 95% CI (confidence interval) \u22123.28 to \u22120.18; p = 0.0292. Due to 87.34% heterogeneity, the performed analysis showed substantive difference in comparisons of postmenopausal women with \u22655 hot flushes per day, when the follow-up period was 12 weeks, with an isoflavone dose of \u226580 mg\/day, and when the formulations contained a higher proportion of biochanin A. The meta-analysis of included studies assessing the effect of red clover isoflavone extract on menopausal symptoms showed a statistically moderate relationship with the reduction in the daily frequency of hot flushes. However, further well-designed studies are required to confirm the present findings and to finally determine the effects of red clover on the relief of flushing episodes.<\/jats:p>","DOI":"10.3390\/nu13041258","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T05:52:00Z","timestamp":1618206720000},"page":"1258","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Evaluation of Clinical Meaningfulness of Red Clover (Trifolium pratense L.) Extract to Relieve Hot Flushes and Menopausal Symptoms in Peri- and Post-Menopausal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.3390","volume":"13","author":[{"given":"Wies\u0142aw","family":"Kanadys","sequence":"first","affiliation":[{"name":"Department of Informatics and Medical Statistics, Medical University of Lublin, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4864-0184","authenticated-orcid":false,"given":"Agnieszka","family":"Bara\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Informatics and Medical Statistics, Medical University of Lublin, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"B\u0142aszczuk","sequence":"additional","affiliation":[{"name":"Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Polz-Dacewicz","sequence":"additional","affiliation":[{"name":"Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart\u0142omiej","family":"Drop","sequence":"additional","affiliation":[{"name":"Department of Informatics and Medical Statistics, Medical University of Lublin, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8931-8565","authenticated-orcid":false,"given":"Krzysztof","family":"Kanecki","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Public Health, Warsaw Medical University, 02-007 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-926X","authenticated-orcid":false,"given":"Maria","family":"Malm","sequence":"additional","affiliation":[{"name":"Department of Informatics and Medical Statistics, Medical University of Lublin, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/13697137.2018.1430131","article-title":"Vasomotor symptoms: Natural history, physiology, and links with cardiovascular health","volume":"21","author":"Thurston","year":"2018","journal-title":"Climacteric"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrendo.2017.180","article-title":"Symptoms of menopause\u2014Global prevalence, physiology and implications","volume":"14","author":"Monteleone","year":"2018","journal-title":"Nat. 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