{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:27:25Z","timestamp":1792020445664,"version":"4.4.0"},"reference-count":75,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["245222810"],"award-info":[{"award-number":["245222810"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Subclinical effects of coffee consumption (CC) with regard to metabolic, cardiac, and neurological complications were evaluated using a whole-body magnetic resonance imaging (MRI) protocol. A blended approach was used to estimate habitual CC in a population-based study cohort without a history of cardiovascular disease. Associations of CC with MRI markers of gray matter volume, white matter hyperintensities, cerebral microhemorrhages, total and visceral adipose tissue (VAT), hepatic proton density fat fraction, early\/late diastolic filling rate, end-diastolic\/-systolic and stroke volume, ejection fraction, peak ejection rate, and myocardial mass were evaluated by linear regression. In our analysis with 132 women and 168 men, CC was positively associated with MR-based cardiac function parameters including late diastolic filling rate, stroke volume (p &lt; 0.01 each), and ejection fraction (p &lt; 0.05) when adjusting for age, sex, smoking, hypertension, diabetes, Low-density lipoprotein (LDL), triglycerides, cholesterol, and alcohol consumption. CC was inversely associated with VAT independent of demographic variables and cardiovascular risk factors (p &lt; 0.05), but this association did not remain significant after additional adjustment for alcohol consumption. CC was not significantly associated with potential neurodegeneration. We found a significant positive and independent association between CC and MRI-based systolic and diastolic cardiac function. CC was also inversely associated with VAT but not independent of alcohol consumption.<\/jats:p>","DOI":"10.3390\/nu13041275","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T10:58:07Z","timestamp":1618311487000},"page":"1275","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Significant Impact of Coffee Consumption on MR-Based Measures of Cardiac Function in a Population-Based Cohort Study without Manifest Cardiovascular Disease"],"prefix":"10.3390","volume":"13","author":[{"given":"Ebba","family":"Beller","sequence":"first","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Center Rostock, 18057 Rostock, Germany"},{"name":"Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lorbeer","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-1024","authenticated-orcid":false,"given":"Daniel","family":"Keeser","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany"},{"name":"Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University Hospital LMU, 80336 Munich, Germany"},{"name":"Munich Center for Neurosciences (MCN)\u2013Brain &amp; Mind, 82152 Planegg-Martinsried, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Gali\u00e8","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix G.","family":"Meinel","sequence":"additional","affiliation":[{"name":"Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Center Rostock, 18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Grosu","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Bamberg","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"},{"name":"University Heart Center Freiburg-Bad Krozingen, 79189 Bad Krozingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Storz","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, 79098 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Schlett","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Medical Center\u2013University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany"},{"name":"University Heart Center Freiburg-Bad Krozingen, 79189 Bad Krozingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Peters","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen-German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany"},{"name":"LMU Munich, IBE-Chair of Epidemiology, 85764 Neuherberg, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 80802 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1084-2442","authenticated-orcid":false,"given":"Alexandra","family":"Schneider","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology, Helmholtz Zentrum M\u00fcnchen-German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9386-382X","authenticated-orcid":false,"given":"Jakob","family":"Linseisen","sequence":"additional","affiliation":[{"name":"Independent Research Group Clinical Epidemiology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany"},{"name":"Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, UNIKA-T Augsburg, 86156 Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Meisinger","sequence":"additional","affiliation":[{"name":"Ludwig-Maximilians Universit\u00e4t M\u00fcnchen, UNIKA-T Augsburg, 86156 Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Rathmann","sequence":"additional","affiliation":[{"name":"German Diabetes Center, Institute of Biometrics and Epidemiology, Leibniz Institute at Heinrich Heine University D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Ertl-Wagner","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Stoecklein","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1017\/S1368980010000509","article-title":"Coffee, tea and caffeine intake and the risk of severe depression in middle-aged Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study","volume":"13","author":"Ruusunen","year":"2010","journal-title":"Public Health Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.3945\/jn.109.109314","article-title":"Coffee consumption and mortality due to all causes, cardiovascular disease, and cancer in Japanese women","volume":"140","author":"Sugiyama","year":"2010","journal-title":"J. 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