{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:14:01Z","timestamp":1793726041694,"version":"4.6.1"},"reference-count":59,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background and aims. Vitamin D is synthesized in the skin with the aid of ultraviolet-B radiation, playing a variety of roles in the body. Temporomandibular disorders (TMDs) are a group of pathological conditions involving the temporomandibular joints as well as the masticatory muscles and othersurrounding tissues. In the present narrative review, we investigated the potential role of vitamin D in the etiology of temporomandibular disorders in order todetermine whether the current knowledge supports 25-hidroxyvitamin D (25-OHD) supplementation in temporomandibular disorders associated with insufficient or deficient levels of vitamin D. Methods. A literature research was performed in PubMed, Scopus, Science Direct, and Google Scholar databases, and a total of 10 articles were included for analysis. Results.Among the observational studies published to date, investigating the role for vitamin D in the etiology of TMDs, six of them suggest that there is a connection between the two aspects. In this context, patients suffering from TMD, with deficient levels of vitamin D (&lt;30 ng\/mL), are most likely to benefit from supplementation, whereas individuals with vitamin D level &gt;50ng\/mL probably have little benefit from supplementation.Conclusion.Vitamin D might be a safe, simple, and potentially beneficial way to prevent TMDs or to reduce pain; however, more randomized and placebo-controlled trials are required before any firm conclusions can be drawn.<\/jats:p>","DOI":"10.3390\/nu13041286","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T04:21:08Z","timestamp":1618374068000},"page":"1286","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin D and Temporomandibular Disorders: What Do We Know So Far?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-8121","authenticated-orcid":false,"given":"Andreea","family":"Kui","sequence":"first","affiliation":[{"name":"Prosthodontics Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4209-9884","authenticated-orcid":false,"given":"Smaranda","family":"Buduru","sequence":"additional","affiliation":[{"name":"Prosthodontics Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3285-8365","authenticated-orcid":false,"given":"Anca","family":"Labunet","sequence":"additional","affiliation":[{"name":"Dental Materials Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Balhuc","sequence":"additional","affiliation":[{"name":"Prosthodontics Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Negucioiu","sequence":"additional","affiliation":[{"name":"Prosthodontics Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"ref_1","first-page":"CD007771","article-title":"Vitamin D for the treatment of chronic painful conditions in adults","volume":"5","author":"Straube","year":"2015","journal-title":"Cochrane Database Syst. 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