{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:58:54Z","timestamp":1792119534504,"version":"4.4.0"},"reference-count":34,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Approximately 70% of birch pollen allergic patients in Europe experience hypersensitivity reactions to Immunoglobulin E (IgE) cross-reactive food sources. This so-called pollen-food syndrome (PFS) is defined by allergic symptoms elicited promptly by the ingestion of fruits, nuts, or vegetables in these patients. So far, in the literature, less attention has been given to Bet v 1 cross-reactive symptoms caused by pear (Pyrus communis). In the Netherlands, pears are widely consumed. The primary objective of this study was to measure the type and severity of allergic symptoms during pear challenges in birch pollen allergic patients, with a positive history of pear allergy, using two different pear varieties. Fifteen patients were included, skin prick test (SPT), prick-to-prick test (PTP), specific Immunoglobulin E (sIgE), and single-blind oral challenges were performed with two pear (Pyrus communis) varieties: the \u2018Cepuna\u2019 (brand name Migo\u00ae) and the \u2018Conference\u2019 pears. All patients were sensitized to one or both pear varieties. A total of 12 out of 15 participants developed symptoms during the \u2018Cepuna\u2019 food challenge and 14\/15 reacted during the \u2018Conference\u2019 challenge. Challenges with the \u2018Cepuna\u2019 pears resulted in less objective symptoms (n = 2) in comparison with challenges with \u2018Conference\u2019 pears (n = 7). Although we did not find significance between both varieties in our study, we found a high likelihood of fewer and less severe symptoms during the \u2018Cepuna\u2019 challenges. Consequently selected pear sensitized patients can try to consume small doses of the \u2018Cepuna\u2019 pear outside the birch pollen season.<\/jats:p>","DOI":"10.3390\/nu13041355","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T06:35:53Z","timestamp":1618814153000},"page":"1355","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Birch Pollen Related Pear Allergy: A Single-Blind Oral Challenge TRIAL with 2 Pear Cultivars"],"prefix":"10.3390","volume":"13","author":[{"given":"Nicolette W.","family":"de Jong","sequence":"first","affiliation":[{"name":"Internal Medicine, Allergology &amp; Clinical Immunology, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Severina","family":"Terlouw","sequence":"additional","affiliation":[{"name":"Internal Medicine, Allergology &amp; Clinical Immunology, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank E.","family":"van Boven","sequence":"additional","affiliation":[{"name":"Internal Medicine, Allergology &amp; Clinical Immunology, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.S.","family":"van Maaren","sequence":"additional","affiliation":[{"name":"Internal Medicine, Allergology &amp; Clinical Immunology, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco W.J.","family":"Schreurs","sequence":"additional","affiliation":[{"name":"Department of Immunology, Laboratory Medical Immunology, Erasmus MC, University Medical Centre, 3015 GD Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne B.P.M.","family":"van den Berg-Somhorst","sequence":"additional","affiliation":[{"name":"Wageningen Food &amp; Biobased Research, Wageningen University &amp; Research Centre, 6708 WE Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diederik","family":"Esser","sequence":"additional","affiliation":[{"name":"Wageningen Food &amp; Biobased Research, Wageningen University &amp; Research Centre, 6708 WE Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanna","family":"Bastiaan-Net","sequence":"additional","affiliation":[{"name":"Wageningen Food &amp; Biobased Research, Wageningen University &amp; Research Centre, 6708 WE Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/all.13758","article-title":"Birch pollen allergy in Europe","volume":"74","author":"Biedermann","year":"2019","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2500\/ajra.2011.25.3551","article-title":"Recombinant marker allergens in diagnosis of patients with allergic rhinoconjunctivitis to tree and grass pollens","volume":"25","author":"Canis","year":"2011","journal-title":"Am. 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