{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:24:26Z","timestamp":1791239066937,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CJ Foods R &amp; D Center, CJ CheilJedang Corporation","award":["KHU Grant No. 20151196"],"award-info":[{"award-number":["KHU Grant No. 20151196"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Lactobacillus plantarum CJLP55 has anti-pathogenic bacterial and anti-inflammatory activities in vitro. We investigated the dietary effect of CJLP55 supplement in patients with acne vulgaris, a prevalent inflammatory skin condition. Subjects ingested CJLP55 or placebo (n = 14 per group) supplements for 12 weeks in this double-blind, placebo-controlled randomized study. Acne lesion count and grade, skin sebum, hydration, pH and surface lipids were assessed. Metagenomic DNA analysis was performed on urine extracellular vesicles (EV), which indirectly reflect systemic bacterial flora. Compared to the placebo supplement, CJLP55 supplement improved acne lesion count and grade, decreased sebum triglycerides (TG), and increased hydration and ceramide 2, the major ceramide species that maintains the epidermal lipid barrier for hydration. In addition, CJLP55 supplement decreased the prevalence of Proteobacteria and increased Firmicutes, which were correlated with decreased TG, the major skin surface lipid of sebum origin. CJLP55 supplement further decreased the Bacteroidetes:Firmicutes ratio, a relevant marker of bacterial dysbiosis. No differences in skin pH, other skin surface lipids or urine bacterial EV phylum were noted between CJLP55 and placebo supplements. Dietary Lactobacillus plantarum CJLP55 was beneficial to clinical state, skin sebum, and hydration and urine bacterial EV phylum flora in patients with acne vulgaris.<\/jats:p>","DOI":"10.3390\/nu13041368","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T11:21:38Z","timestamp":1618831298000},"page":"1368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Effects of Lactobacillus plantarum CJLP55 on Clinical Improvement, Skin Condition and Urine Bacterial Extracellular Vesicles in Patients with Acne Vulgaris: A Randomized, Double-Blind, Placebo-Controlled Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Mi-Ju","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si 17104, Gyeongggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2785-5351","authenticated-orcid":false,"given":"Kun-Pyo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si 17104, Gyeongggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhye","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si 17104, Gyeongggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June-Hyuck","family":"Yim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kyung Hee University Medical Center, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunpil","family":"Choi","sequence":"additional","affiliation":[{"name":"Skyfeel Dermatologic Clinic, Seoul 06020, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Sun","family":"Yun","sequence":"additional","affiliation":[{"name":"CJ Foods R &amp; D Center, CJ CheilJedang Corporation, Suwon-si 16495, Gyeongggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Yoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"CJ Foods R &amp; D Center, CJ CheilJedang Corporation, Suwon-si 16495, Gyeongggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Young","family":"Oh","sequence":"additional","affiliation":[{"name":"CJ Foods R &amp; D Center, CJ CheilJedang Corporation, Suwon-si 16495, Gyeongggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6916-4482","authenticated-orcid":false,"given":"Yunhi","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si 17104, Gyeongggi-do, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1600-0625.2009.00890.x","article-title":"New developments in our understanding of acne pathogenesis and treatment","volume":"18","author":"Kurokawa","year":"2009","journal-title":"Exp. 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