{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:59:38Z","timestamp":1791547178800,"version":"4.3.4"},"reference-count":133,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diet is a modifiable factor that ensures optimal growth, biochemical performance, improved mood and mental functioning. Lack of nutrients, notably vitamin B, has an impact on human health and wellbeing. The United Arab Emirates is facing a serious problem of micronutrient deficiencies because of the growing trend for bariatric surgery, including Roux-en-Y gastric bypass and sleeve gastrectomy. People undergoing bariatric surgery are at high risk of developing neurological, cognitive, and mental disabilities and cardiovascular disease due to deficiency in vitamin B. Vitamin B is involved in neurotransmitter synthesis, including \u03b3-aminobutyric acid, serotonin, dopamine, and noradrenaline. Deficiency of vitamin B increases the risk of depression, anxiety, dementia and Alzheimer\u2019s disease. In addition, vitamin B deficiency can disrupt the methylation of homocysteine, leading to hyperhomocysteinemia. Elevated homocysteine levels are detrimental to human health. Vitamin B deficiency also suppresses immune function, increases the production of pro-inflammatory cytokines and upregulates NF-\u03baB. Considering the important functions of vitamin B and the severe consequences associated with its deficiency following bariatric surgery, proper dietary intervention and administration of adequate supplements should be considered to prevent negative clinical outcomes.<\/jats:p>","DOI":"10.3390\/nu13041383","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T13:58:04Z","timestamp":1618927084000},"page":"1383","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The Effects of Bariatric Surgery on Vitamin B Status and Mental Health"],"prefix":"10.3390","volume":"13","author":[{"given":"Amna","family":"Al Mansoori","sequence":"first","affiliation":[{"name":"Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-9283","authenticated-orcid":false,"given":"Hira","family":"Shakoor","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2685-1244","authenticated-orcid":false,"given":"Habiba I.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9627-1299","authenticated-orcid":false,"given":"Jack","family":"Feehan","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia"},{"name":"Department of Medicine-Western Health, The University of Melbourne, Melbourne, VIC 8001, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7634-3531","authenticated-orcid":false,"given":"Ayesha S.","family":"Al Dhaheri","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Cheikh Ismail","sequence":"additional","affiliation":[{"name":"Clinical Nutrition and Dietetics Department, College of Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates"},{"name":"Nuffield Department of Women\u2019s &amp; Reproductive Health, University of Oxford, Oxford OX1 2JD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1897-7832","authenticated-orcid":false,"given":"Marijan","family":"Bosevski","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Skopje, University Clinic of Cardiology, University of Ss. Cyril and Methodius, 1010 Skopje, North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-2771","authenticated-orcid":false,"given":"Vasso","family":"Apostolopoulos","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Stojanovska","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates"},{"name":"Institute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/obr.12605","article-title":"Double burden of diseases worldwide: Coexistence of undernutrition and overnutrition-related non-communicable chronic diseases","volume":"19","author":"Min","year":"2018","journal-title":"Obes. Rev."},{"key":"ref_2","unstructured":"Center for Disease Control and Prevention (2016). Micronutrient Malnutrition: Reducing Nutritional Deficiencies Globally, National Center for Chronic Disease Prevention and Health Promotion."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.soard.2014.07.017","article-title":"Exploring the impact of bariatric surgery on high density lipoprotein","volume":"11","author":"Aminian","year":"2015","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s11695-017-2607-8","article-title":"Neurologic manifestations of vitamin B deficiency after bariatric surgery","volume":"27","author":"Punchai","year":"2017","journal-title":"Obes. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.nut.2009.12.003","article-title":"Micronutrient deficiencies after bariatric surgery","volume":"26","author":"Shankar","year":"2010","journal-title":"Nutrition"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00000441-200604000-00007","article-title":"Nutritional management of patients after bariatric surgery","volume":"331","author":"Parkes","year":"2006","journal-title":"Am. J. Med. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e12290","DOI":"10.1111\/cob.12290","article-title":"Mental health quality of life after bariatric surgery: A systematic review and meta-analysis of randomized clinical trials","volume":"9","author":"Szmulewicz","year":"2019","journal-title":"Clin. Obes."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0166-2236(03)00032-8","article-title":"Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders","volume":"26","author":"Mattson","year":"2003","journal-title":"Trends Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.maturitas.2016.11.012","article-title":"The effects of vitamin B on the immune\/cytokine network and their involvement in depression","volume":"96","author":"Mikkelsen","year":"2017","journal-title":"Maturitas"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Hughes, C.F., Ward, M., Tracey, F., Hoey, L., Molloy, A.M., Pentieva, K., and McNulty, H. (2017). B-vitamin intake and biomarker status in relation to cognitive decline in healthy older adults in a 4-year follow-up study. Nutrients, 9.","DOI":"10.3390\/nu9010053"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1093\/ajcn\/75.5.908","article-title":"Homocysteine, B vitamin status, and cognitive function in the elderly","volume":"75","author":"Duthie","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00213-010-1870-3","article-title":"Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males","volume":"211","author":"Kennedy","year":"2010","journal-title":"Psychopharmacology"},{"key":"ref_13","first-page":"1","article-title":"The effect of methylated vitamin B complex on depressive and anxiety symptoms and quality of life in adults with depression","volume":"2013","author":"Lewis","year":"2013","journal-title":"Int. Sch. Res. Not."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1192\/bjp.bp.109.075291","article-title":"Mental health literacy, folic acid and vitamin B 12, and physical activity for the prevention of depression in older adults: Randomised controlled trial","volume":"197","author":"Walker","year":"2010","journal-title":"Br. J. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/jnnp.53.11.951","article-title":"Vitamin B12 and folate concentrations in serum and cerebrospinal fluid of neurological patients with special reference to multiple sclerosis and dementia","volume":"53","author":"Nijst","year":"1990","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1192\/bjp.113.501.911","article-title":"Schizophrenia-like psychoses of epilepsy and disturbances of folate and vitamin B 12 metabolism induced by anticonvulsant drugs","volume":"113","author":"Reynolds","year":"1967","journal-title":"Br. J. Psychiatry"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3945\/an.114.007526","article-title":"Thiamin deficiency in people with obesity","volume":"6","author":"Kerns","year":"2015","journal-title":"Adv. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/j.1471-4159.2009.06417.x","article-title":"Vitamin-regulated cytokines and growth factors in the CNS and elsewhere","volume":"111","author":"Scalabrino","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mikkelsen, K., Prakash, M.D., Kuol, N., Nurgali, K., Stojanovska, L., and Apostolopoulos, V. (2019). Anti-Tumor Effects of Vitamin B2, B6 and B9 in Promonocytic Lymphoma Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20153763"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.abb.2015.08.013","article-title":"Ameliorative effect of riboflavin on hyperglycemia, oxidative stress and DNA damage in type-2 diabetic mice: Mechanistic and therapeutic strategies","volume":"584","author":"Alam","year":"2015","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kennedy, D.O. (2016). B vitamins and the brain: Mechanisms, dose and efficacy\u2014A review. Nutrients, 8.","DOI":"10.3390\/nu8020068"},{"key":"ref_22","first-page":"283","article-title":"Crosstalk between vitamin B and immunity","volume":"29","author":"Spinas","year":"2015","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_23","unstructured":"Pitkin, R.M., Allen, L.H., Bailey, L.B., and Bernfield, M. (2000). Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline, National Academy Press."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s00210-013-0854-3","article-title":"Niacin inhibits carrageenan-induced neutrophil migration in mice","volume":"386","author":"Ferreira","year":"2013","journal-title":"Naunyn Schmiedeberg Arch. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijfoodmicro.2010.03.038","article-title":"The influence of pomegranate by-product and punicalagins on selected groups of human intestinal microbiota","volume":"140","author":"Bialonska","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","article-title":"NAD+ and sirtuins in aging and disease","volume":"24","author":"Imai","year":"2014","journal-title":"Trends Cell Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"132","DOI":"10.12688\/f1000research.12120.1","article-title":"NAD+ biosynthesis, aging, and disease","volume":"7","author":"Johnson","year":"2018","journal-title":"F1000Research"},{"key":"ref_28","unstructured":"Maqbool, M.A., Aslam, M., Akbar, W., and Iqbal, Z. (2018). Biological importance of vitamins for human health: A review. J. Agric. Basic Sci., 2."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/01.mog.0000203870.22706.52","article-title":"Intestinal absorption of water-soluble vitamins: An update","volume":"22","author":"Said","year":"2006","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"C1219","DOI":"10.1152\/ajpcell.00204.2003","article-title":"A carrier-mediated mechanism for pyridoxine uptake by human intestinal epithelial Caco-2 cells: Regulation by a PKA-mediated pathway","volume":"285","author":"Said","year":"2003","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1111\/j.1753-4887.2004.tb00070.x","article-title":"Physiology of folate and vitamin B 12 in health and disease","volume":"62","author":"Stover","year":"2004","journal-title":"Nutr. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12934-017-0631-y","article-title":"Microbial production of vitamin B 12: A review and future perspectives","volume":"16","author":"Fang","year":"2017","journal-title":"Microb. Cell Factories"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3390\/nu2030299","article-title":"Vitamin B12 in health and disease","volume":"2","author":"Samman","year":"2010","journal-title":"Nutrients"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.clim.2014.03.014","article-title":"Impact of folate therapy on combined immunodeficiency secondary to hereditary folate malabsorption","volume":"153","author":"Kishimoto","year":"2014","journal-title":"Clin. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.biochi.2013.01.002","article-title":"Cobalamin and normal prions: A new horizon for cobalamin neurotrophism","volume":"95","author":"Scalabrino","year":"2013","journal-title":"Biochimie"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/1721727X1401200304","article-title":"The Relationship between Soluble Tumor Necrosis Factor-like Weak Inducer of Apoptosis Levels and Cardiac Functions in Peritoneal Dialysis Patients","volume":"12","author":"Karadag","year":"2014","journal-title":"Eur. J. Inflamm."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kritas, S.K., Caraffa, A., Antinolfi, P., Saggini, A., Pantalone, A., Rosati, M., Tei, M., Speziali, A., Saggini, R., and Pandolfi, F. (2014). Nerve Growth Factor Interactions with Mast Cells, SAGE Publications Sage UK.","DOI":"10.1177\/039463201402700103"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2147\/COPD.S2147","article-title":"Plasma homocysteine is elevated in COPD patients and is related to COPD severity","volume":"2","author":"Seemungal","year":"2007","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1365-2249.1999.00870.x","article-title":"Immunomodulation by vitamin B12: Augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment","volume":"116","author":"Tamura","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1080\/10408398.2016.1145104","article-title":"Riboflavin and health: A review of recent human research","volume":"57","author":"Thakur","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9794","DOI":"10.1523\/JNEUROSCI.2116-06.2006","article-title":"Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models","volume":"26","author":"Kaneko","year":"2006","journal-title":"J. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chai, J.T., Digby, J.E., Ruparelia, N., Jefferson, A., Handa, A., and Choudhury, R.P. (2013). Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062934"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fimmu.2018.00365","article-title":"Vitamin B5 reduces bacterial growth via regulating innate immunity and adaptive immunity in mice infected with Mycobacterium tuberculosis","volume":"9","author":"He","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1093\/jn\/133.10.3233","article-title":"Dietary folate and depressive symptoms are associated in middle-aged Finnish men","volume":"133","author":"Tolmunen","year":"2003","journal-title":"J. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1189\/jlb.0607428","article-title":"Biotin deficiency up-regulates TNF-\u03b1 production in murine macrophages","volume":"83","author":"Kuroishi","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0165-5728(02)00095-4","article-title":"Cobalamin (vitamin B12) positively regulates interleukin-6 levels in rat cerebrospinal fluid","volume":"127","author":"Scalabrino","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1212\/01.wnl.0000325581.26991.f2","article-title":"Vitamin B12 status and rate of brain volume loss in community-dwelling elderly","volume":"71","author":"Vogiatzoglou","year":"2008","journal-title":"Neurology"},{"key":"ref_48","first-page":"827","article-title":"Revisional bariatric surgery","volume":"96","author":"Switzer","year":"2016","journal-title":"Surg. Clin."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.diabet.2013.11.003","article-title":"Gastrointestinal changes after bariatric surgery","volume":"40","author":"Quercia","year":"2014","journal-title":"Diabetes Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1007\/s11695-018-3450-2","article-title":"IFSO worldwide survey 2016: Primary, endoluminal, and revisional procedures","volume":"28","author":"Angrisani","year":"2018","journal-title":"Obes. Surg."},{"key":"ref_51","first-page":"9","article-title":"Nutritional Concerns in Bariatric Surgery: Thiamin Deficiency after Sleeve Gastrectomy","volume":"38","author":"Strang","year":"2016","journal-title":"Support. Line"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11910-015-0597-2","article-title":"Neurological complications of bariatric surgery","volume":"15","author":"Goodman","year":"2015","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S1262-3636(09)73464-0","article-title":"Medical follow up after bariatric surgery: Nutritional and drug issues General recommendations for the prevention and treatment of nutritional deficiencies","volume":"35","author":"Ziegler","year":"2009","journal-title":"Diabetes Metab."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/ajcn\/87.5.1128","article-title":"Nutritional deficiencies after Roux-en-Y gastric bypass for morbid obesity often cannot be prevented by standard multivitamin supplementation","volume":"87","author":"Gasteyger","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"602S","DOI":"10.1093\/ajcn\/55.2.602s","article-title":"Metabolic risk of obesity surgery and long-term follow-up","volume":"55","author":"Halverson","year":"1992","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.soard.2013.12.005","article-title":"Anemia, iron and vitamin B12 deficiencies after sleeve gastrectomy compared to Roux-en-Y gastric bypass: A meta-analysis","volume":"10","author":"Kwon","year":"2014","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0140-6736(97)11074-1","article-title":"A man who lost weight and his sight","volume":"351","author":"Moschos","year":"1998","journal-title":"Lancet"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2193-1801-2-218","article-title":"An audit to determine if vitamin b12 supplementation is necessary after sleeve gastrectomy","volume":"2","author":"Eltweri","year":"2013","journal-title":"SpringerPlus"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Gagner, M., Deitel, M., Erickson, A.L., and Crosby, R.D. (2013). Survey on laparoscopic sleeve gastrectomy (LSG) at the Fourth International Consensus Summit on Sleeve Gastrectomy. Obes. Surg., 23.","DOI":"10.1007\/s11695-013-1040-x"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11695-008-9545-4","article-title":"Evidence for the necessity to systematically assess micronutrient status prior to bariatric surgery","volume":"19","author":"Ernst","year":"2009","journal-title":"Obes. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11695-019-04167-x","article-title":"Micronutrient Deficiencies After Roux-en-Y Gastric Bypass: Long-Term Results","volume":"30","author":"Arias","year":"2020","journal-title":"Obes. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.nut.2009.03.012","article-title":"Prevalence of nutrient deficiencies in bariatric patients","volume":"25","author":"Toh","year":"2009","journal-title":"Nutrition"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s11695-007-9310-0","article-title":"Prevalence of iron, folate, and vitamin B12 deficiency anemia after laparoscopic Roux-en-Y gastric bypass","volume":"18","author":"Herrera","year":"2008","journal-title":"Obes. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1007\/s11695-019-03985-3","article-title":"Nutritional deficiencies in patients after Roux-en-Y gastric bypass and sleeve gastrectomy during 12-month follow-up","volume":"29","author":"Antoniewicz","year":"2019","journal-title":"Obes. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.soard.2019.04.028","article-title":"Analysis of vitamin levels and deficiencies in bariatric surgery patients: A single-institutional analysis","volume":"15","author":"Johnson","year":"2019","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11914-014-0209-0","article-title":"Endocrine crosstalk between muscle and bone","volume":"12","author":"Brotto","year":"2014","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_67","first-page":"594","article-title":"Micronutrient deficiencies after gastric bypass for morbid obesity","volume":"52","author":"Halverson","year":"1986","journal-title":"Am. Surg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1007\/s11695-018-3336-3","article-title":"Two-Year Nutrition Data in Terms of Vitamin D, Vitamin B12, and Albumin After Bariatric Surgery and Long-term Fracture Data Compared with Conservatively Treated Obese Patients: A Retrospective Cohort Study","volume":"28","author":"Javanainen","year":"2018","journal-title":"Obes. Surg."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Christensen, M.H.E., Fadnes, D.J., R\u00f8st, T.H., Pedersen, E.R., Andersen, J.R., V\u00e5ge, V., Ulvik, A., Midttun, \u00d8., Ueland, P.M., and Nyg\u00e5rd, O.K. (2018). Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0192169"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3945\/ajcn.2009.27583","article-title":"Vitamin status after bariatric surgery: A randomized study of gastric bypass and duodenal switch","volume":"90","author":"Aasheim","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.soard.2018.03.029","article-title":"Do specialized bariatric multivitamins lower deficiencies after RYGB?","volume":"14","author":"Schijns","year":"2018","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1007\/s11695-015-1952-8","article-title":"Improving Bariatric Patient Aftercare Outcome by Improved Detection of a Functional Vitamin B12 Deficiency","volume":"26","author":"Smelt","year":"2016","journal-title":"Obes. Surg."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Al-Mutawa, A., Anderson, A.K., Alsabah, S., and Al-Mutawa, M. (2018). Nutritional Status of Bariatric Surgery Candidates. Nutrients, 10.","DOI":"10.3390\/nu10010067"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11695-015-1773-9","article-title":"Micronutrient Deficiencies in Morbidly Obese Women Prior to Bariatric Surgery","volume":"26","author":"Rojas","year":"2016","journal-title":"Obes. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s11695-017-2902-4","article-title":"Prevalence of micronutrient deficiency in patients with morbid obesity before bariatric surgery","volume":"28","author":"Krzizek","year":"2018","journal-title":"Obes. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s11695-018-3187-y","article-title":"Prevalence of Micronutrient Deficiencies Prior to Bariatric Surgery: Tehran Obesity Treatment Study (TOTS)","volume":"28","author":"Asghari","year":"2018","journal-title":"Obes. Surg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11695-009-0008-3","article-title":"Nutritional deficiencies in bariatric surgery candidates","volume":"20","author":"Schweiger","year":"2010","journal-title":"Obes. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1007\/s11695-014-1225-y","article-title":"Nutrient Deficiencies Before and After Sleeve Gastrectomy","volume":"24","author":"Aarts","year":"2014","journal-title":"Obes. Surg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1089\/bari.2017.0008","article-title":"Homocysteine and Cognition in Bariatric Surgery","volume":"12","author":"Wilhelm","year":"2017","journal-title":"Bariatr. Surg. Pract. Patient Care"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s11695-014-1441-5","article-title":"Effectiveness of B Vitamin Supplementation Following Bariatric Surgery: Rapid Increases of Serum Vitamin B 12","volume":"25","author":"Moore","year":"2015","journal-title":"Obes. Surg."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.clnu.2018.02.007","article-title":"Early changes in vitamin B12 uptake and biomarker status following Roux-en-Y gastric bypass and sleeve gastrectomy","volume":"38","author":"Kornerup","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Weng, T.C., Chang, C.H., Dong, Y.H., Chang, Y.C., and Chuang, L.M. (2015). Anaemia and related nutrient deficiencies after Roux-en-Y gastric bypass surgery: A systematic review and meta-analysis. BMJ Open, 5.","DOI":"10.1136\/bmjopen-2014-006964"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.soard.2013.04.017","article-title":"Vitamin B12 deficiency in patients undergoing bariatric surgery: Preventive strategies and key recommendations","volume":"9","author":"Majumder","year":"2013","journal-title":"Surg. Obes. Relat. Dis. Off. J. Am. Soc. Bariatr. Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1007\/BF01537272","article-title":"Absence of luminal intrinsic factor after gastric bypass surgery for morbid obesity","volume":"34","author":"Marcuard","year":"1989","journal-title":"Dig. Dis. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11695-020-04392-9","article-title":"The relationship between bariatric surgery and diet quality: A systematic review","volume":"30","author":"Zarshenas","year":"2020","journal-title":"Obes. Surg."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1007\/s11695-019-04100-2","article-title":"Nutritional Deficiencies, Bariatric Surgery, and Serum Homocysteine Level: Review of Current Literature","volume":"29","author":"Komorniak","year":"2019","journal-title":"Obes. Surg."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"241","DOI":"10.17712\/nsj.2016.3.20160039","article-title":"Neurological complications of bariatric surgery","volume":"21","author":"Algahtani","year":"2016","journal-title":"Neurosciences"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1007\/s11695-014-1376-x","article-title":"Neurological complications of bariatric surgery","volume":"24","author":"Landais","year":"2014","journal-title":"Obes. Surg."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Oudman, E., Wijnia, J.W., Van Dam, M., Biter, L.U., and Postma, A. (2018). Preventing Wernicke Encephalopathy After Bariatric Surgery. Obes. Surg., 1\u20139.","DOI":"10.1007\/s11695-018-3262-4"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s11695-016-2449-9","article-title":"Different supplementation regimes to treat perioperative vitamin B12 deficiencies in bariatric surgery: A systematic review","volume":"27","author":"Smelt","year":"2017","journal-title":"Obes. Surg."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1381\/096089206778026415","article-title":"Comparison of nutritional consequences of conventional therapy of obesity, adjustable gastric banding, and gastric bypass","volume":"16","author":"Ledoux","year":"2006","journal-title":"Obes. Surg."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11695-010-0269-x","article-title":"Determinants of hyperhomocysteinemia after gastric bypass surgery in obese subjects","volume":"21","author":"Ledoux","year":"2011","journal-title":"Obes. Surg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1017\/jns.2020.41","article-title":"Patient adherence to multivitamin supplementation after bariatric surgery: A narrative review","volume":"9","author":"Smelt","year":"2020","journal-title":"J. Nutr. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1007\/s11695-019-03750-6","article-title":"Adequate multivitamin supplementation after Roux-En-Y gastric bypass results in a decrease of national health care costs: A cost-effectiveness analysis","volume":"29","author":"Homan","year":"2019","journal-title":"Obes. Surg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/sj.ijo.0801474","article-title":"Elevated homocysteine levels with weight loss after Lap-Band\u00ae surgery: Higher folate and vitamin B 12 levels required to maintain homocysteine level","volume":"25","author":"Dixon","year":"2001","journal-title":"Int. J. Obes."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.neurobiolaging.2014.03.040","article-title":"Critical levels of brain atrophy associated with homocysteine and cognitive decline","volume":"35","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.maturitas.2016.08.001","article-title":"Cognitive decline: A vitamin B perspective","volume":"93","author":"Mikkelsen","year":"2016","journal-title":"Maturitas"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S1474-4422(06)70598-1","article-title":"Vitamin B12, folic acid, and the nervous system","volume":"5","author":"Reynolds","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/nyas.13031","article-title":"Vitamin B1 (thiamine) and dementia","volume":"1367","author":"Gibson","year":"2016","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/oby.20738","article-title":"Course of depressive symptoms and treatment in the longitudinal assessment of bariatric surgery (LABS-2) study","volume":"22","author":"Mitchell","year":"2014","journal-title":"Obesity"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.1007\/s11695-018-3371-0","article-title":"Depression before and after bariatric surgery in low-income patients: The utility of the beck depression inventory","volume":"28","author":"Alabi","year":"2018","journal-title":"Obes. Surg."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1001\/jama.2015.18118","article-title":"Mental health conditions among patients seeking and undergoing bariatric surgery: A meta-analysis","volume":"315","author":"Dawes","year":"2016","journal-title":"JAMA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/oby.21814","article-title":"Mental illness in bariatric surgery: A cohort study from the PORTAL network","volume":"25","author":"Fisher","year":"2017","journal-title":"Obesity"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s11695-018-3493-4","article-title":"Risk of suicide and self-harm is increased after bariatric surgery\u2014a systematic review and meta-analysis","volume":"29","author":"Castaneda","year":"2019","journal-title":"Obes. Surg."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/oby.22752","article-title":"Mental Health in Bariatric Surgery: Selection, Access, and Outcomes","volume":"28","author":"Morledge","year":"2020","journal-title":"Obesity"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.soard.2011.04.036","article-title":"P-35 The effect of gastric bypass on the pharmacokinetics of serotonin reuptake inhibitors","volume":"7","author":"Hamad","year":"2011","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e12998","DOI":"10.1111\/obr.12998","article-title":"Psychological outcomes following surgical and endoscopic bariatric procedures: A systematic review","volume":"21","author":"Spirou","year":"2020","journal-title":"Obes. Rev."},{"key":"ref_108","first-page":"65","article-title":"Psychotic depression after obesity surgery and recovery with vitamin B12 replacement","volume":"32","author":"Sozer","year":"2019","journal-title":"Dusunen Adam J. Psychiatry Neurol. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11695-014-1402-z","article-title":"When Mood Worsens after Gastric Bypass Surgery: Characterization of Bariatric Patients with Increases in Depressive Symptoms Following Surgery","volume":"25","author":"Ivezaj","year":"2015","journal-title":"Obes. Surger"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1007\/s11695-018-3392-8","article-title":"Does bariatric surgery cause vitamin A, B1, C or E deficiency? A systematic review","volume":"28","author":"Lewis","year":"2018","journal-title":"Obes. Surg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/erv.2292","article-title":"Wernicke encephalopathy in subjects undergoing restrictive weight loss surgery: A systematic review of literature data","volume":"22","author":"Milone","year":"2014","journal-title":"Eur. Eat. Disord. Rev."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.neurol.2011.01.011","article-title":"Peripheral neuropathies after bariatric surgery","volume":"167","author":"Philippi","year":"2011","journal-title":"Rev. Neurol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1212\/01.WNL.0000142038.43946.06","article-title":"A controlled study of peripheral neuropathy after bariatric surgery","volume":"63","author":"Thaisetthawatkul","year":"2004","journal-title":"Neurology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1007\/s11695-017-3102-y","article-title":"Oral vitamin B 12 supplementation after Roux-en-Y gastric bypass: A systematic review","volume":"28","author":"Mahawar","year":"2018","journal-title":"Obes. Surg."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/fampra\/cml008","article-title":"Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency: A systematic review of randomized controlled trials","volume":"23","author":"Butler","year":"2006","journal-title":"Fam. Pract."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jviscsurg.2020.10.013","article-title":"Recommendations for nutritional care after bariatric surgery: Recommendations for best practice and SOFFCO-MM\/AFERO\/SFNCM\/expert consensus","volume":"158","author":"Quilliot","year":"2021","journal-title":"J. Visc. Surg."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"693S","DOI":"10.3945\/ajcn.2008.26947A","article-title":"How common is vitamin B-12 deficiency?","volume":"89","author":"Allen","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ajcn\/63.1.103","article-title":"Vitamin B-12 deficiency after gastric surgery for obesity","volume":"63","author":"Rhode","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/07315724.1992.10718193","article-title":"Evidence for diminished B12 absorption after gastric bypass: Oral supplementation does not prevent low plasma B12 levels in bypass patients","volume":"11","author":"Provenzale","year":"1992","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e13087","DOI":"10.1111\/obr.13087","article-title":"British Obesity and Metabolic Surgery Society Guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery\u20142020 update","volume":"21","author":"Parretti","year":"2020","journal-title":"Obes. Rev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S2468-1253(20)30331-9","article-title":"Prevention and treatment of nutritional complications after bariatric surgery","volume":"6","author":"Nuzzo","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/ajcn\/nqy072","article-title":"Efficacy of oral compared with intramuscular vitamin B-12 supplementation after Roux-en-Y gastric bypass: A randomized controlled trial","volume":"108","author":"Schijns","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_123","first-page":"QE01","article-title":"Bariatric surgery in women: A boon needs special care during pregnancy","volume":"9","author":"Kumari","year":"2015","journal-title":"J. Clin. Diagn. Res. JCDR"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/01.ogx.0000279291.86611.46","article-title":"Female reproductive issues following bariatric surgery","volume":"62","author":"Wax","year":"2007","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/492060","article-title":"Nutrition and pregnancy after bariatric surgery","volume":"2013","author":"Kaska","year":"2013","journal-title":"ISRB Obes."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/MPG.0b013e318231db79","article-title":"Nutritional strategy for adolescents undergoing bariatric surgery: Report of a working group of the Nutrition Committee of NASPGHAN\/NACHRI","volume":"54","author":"Fullmer","year":"2012","journal-title":"J. Pediatric Gastroenterol. Nutr."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1053\/j.semperi.2011.05.022","article-title":"Preparing for and managing a pregnancy after bariatric surgery","volume":"35","author":"Kominiarek","year":"2011","journal-title":"Semin. Perinatol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jmwh.2010.06.018","article-title":"Specialized care for women pregnant after bariatric surgery","volume":"55","author":"Harris","year":"2010","journal-title":"J. Midwifery Women Health"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00005237-200410000-00003","article-title":"Pregnancy following bariatric surgery","volume":"18","author":"Woodard","year":"2004","journal-title":"J. Perinat. Neonatal Nurs."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"608534","DOI":"10.1155\/2012\/608534","article-title":"The Neurological Complications of Nutritional Deficiency following Bariatric Surgery","volume":"2012","author":"Becker","year":"2012","journal-title":"J. Obes."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1515\/cclm-2018-1337","article-title":"Reference intervals for serum total vitamin B12 and holotranscobalamin concentrations and their change points with methylmalonic acid concentration to assess vitamin B12 status during early and mid-pregnancy","volume":"57","author":"Schroder","year":"2019","journal-title":"Clin. Chem. Lab. Med. CCLM"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/clinchem\/46.8.1277","article-title":"Cobalamin and folate evaluation: Measurement of methylmalonic acid and homocysteine vs. vitamin B12 and folate","volume":"46","author":"Klee","year":"2000","journal-title":"Clin. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Simoens, C., Verbiest, A., Brenninkmeijer, K., Moyson, C., Matthys, C., Meulemans, A., Lannoo, M., Van der Schueren, B., and Mertens, A. (2020). Nonsurgical complications after bariatric surgery. Proc. Nutr. 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