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Epigenetics is a conjunct of mechanisms (like DNA methylation) that regulate gene expression, which are dependent on environmental changes. Analysis of DNA methylation in eating disorders shows that it is reduced. The present study aimed to analyze the genome-wide DNA methylation differences between individuals diagnosed with BED and BN. A total of 46 individuals were analyzed using the Infinium Methylation EPIC array. We found 11 differentially methylated sites between BED- and BN-diagnosed individuals, with genome-wide significance. Most of the associations were found in genes related to metabolic processes (ST3GAL4, PRKAG2, and FRK), which are hypomethylated genes in BED. Cg04781532, located in the body of the PRKAG2 gene (protein kinase AMP-activated non-catalytic subunit gamma 2), was hypomethylated in individuals with BED. Agonists of PRKAG2, which is the subunit of AMPK (AMP-activated protein kinase), are proposed to treat obesity, BED, and BN. The present study contributes important insights into the effect that BED could have on PRKAG2 activation.<\/jats:p>","DOI":"10.3390\/nu13051413","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T13:59:14Z","timestamp":1619099954000},"page":"1413","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Individuals Diagnosed with Binge-Eating Disorder Have DNA Hypomethylated Sites in Genes of the Metabolic System: A Pilot Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Mariana Lizbeth","family":"Rodr\u00edguez-L\u00f3pez","sequence":"first","affiliation":[{"name":"Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 01090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0390-8252","authenticated-orcid":false,"given":"Jos\u00e9 Jaime","family":"Mart\u00ednez-Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Genomics of Psychiatric and Neurodegenerative Diseases Laboratory, National Institute of Genomic Medicine (INMEGEN), Mexico City 01090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ruiz-Ramos","sequence":"additional","affiliation":[{"name":"Biomedical Postgraduate Program, Academic Division of Health Sciences, Ju\u00e1rez Autonomous University of Tabasco, Villahermosa 86000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Rosa","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Children\u2019s Psychiatric Hospital \u201cDr. Juan N. 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