{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T05:50:08Z","timestamp":1784613008496,"version":"3.55.0"},"reference-count":54,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,2]],"date-time":"2021-05-02T00:00:00Z","timestamp":1619913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NGN s.r.l. grant","award":["Propriet\u00e0 vaso-protettive, vasorilascianti ed anti-ipertensive del nutraceutico Taurisolo\" 32\/2019"],"award-info":[{"award-number":["Propriet\u00e0 vaso-protettive, vasorilascianti ed anti-ipertensive del nutraceutico Taurisolo\" 32\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Preservation of vascular endothelium integrity and functionality represents an unmet medical need. Indeed, endothelial dysfunction leads to decreased nitric oxide biosynthesis, which is prodromic of hypertension and hypercoagulability. In this panorama, the nutraceutical supplement Taurisolo\u00ae, a polyphenolic extract from Aglianico cultivar grape, rich in catechin and procyanidins, was evaluated as a vasoprotective, vasorelaxing, anti-hypertensive and anti-coagulant agent in: cell lines, isolated vessels, in vivo models of chronic hypertension and hypercoagulability, and in clinical tests of endothelial reactivity. Taurisolo\u00ae demonstrated to fully protect vascular cell viability from oxidative stimulus at 100 \u00b5g\/mL and evoke vasorelaxing effects (Emax = 80.6% \u00b1 1.9 and pEC50 = 1.19 \u00b1 0.03) by activation of the Sirtuins-AMPK-pathway. Moreover, Taurisolo\u00ae, chronically administered at 20 mg\/Kg\/die in in vivo experiments, inhibited the onset of cardiac hypertrophy (heart weight\/rat weight = 3.96 \u00b1 0.09 vs. 4.30 \u00b1 0.03), hypercoagulability (decrease of fibrinogen vs. control: p &lt; 0.01) and hypertension (mean of Psys: 200 \u00b1 2 vs. control 234 \u00b1 2 mmHg) and improved endothelial function (Emax = 88.9% \u00b1 1.5 vs. control 59.6% \u00b1 3.6; flow-mediated dilation in healthy volunteers after 400 mg twice daily for 8 weeks vs. baseline: p = 0.019). In conclusion, Taurisolo\u00ae preserves the vascular function against ox-inflamm-ageing process and the consequent cardiovascular accidents.<\/jats:p>","DOI":"10.3390\/nu13051540","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T22:51:42Z","timestamp":1620255102000},"page":"1540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo\u00ae: Focus on the Protection of the Endothelial Function"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2090-7107","authenticated-orcid":false,"given":"Alma","family":"Martelli","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"},{"name":"Interdepartmental Research Center \u201cNutrafood: Nutraceutica e Alimentazione per la Salute\u201d, University of Pisa, 56126 Pisa, Italy"},{"name":"Interdepartmental Research Center \u201cBiology and Pathology of Ageing\u201d, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Flori","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Era","family":"Gorica","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6558-3065","authenticated-orcid":false,"given":"Eugenia","family":"Piragine","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anella","family":"Saviano","sequence":"additional","affiliation":[{"name":"ImmunoPharmaLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1922-662X","authenticated-orcid":false,"given":"Giuseppe","family":"Annunziata","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-3819","authenticated-orcid":false,"given":"Matteo Nicola Dario","family":"Di Minno","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Ciampaglia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-2809","authenticated-orcid":false,"given":"Ilenia","family":"Calcaterra","sequence":"additional","affiliation":[{"name":"Department of Clinic Medicine and Surgery, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-4299","authenticated-orcid":false,"given":"Francesco","family":"Maione","sequence":"additional","affiliation":[{"name":"ImmunoPharmaLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0251-9936","authenticated-orcid":false,"given":"Gian Carlo","family":"Tenore","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Novellino","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Calderone","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy"},{"name":"Interdepartmental Research Center \u201cNutrafood: Nutraceutica e Alimentazione per la Salute\u201d, University of Pisa, 56126 Pisa, Italy"},{"name":"Interdepartmental Research Center \u201cBiology and Pathology of Ageing\u201d, University of Pisa, 56126 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","article-title":"Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force","volume":"39","author":"Corretti","year":"2002","journal-title":"J. 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