{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T20:04:41Z","timestamp":1788120281770,"version":"build-2803163510"},"reference-count":103,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is a heterogenous disorder characterized by chronic ovulation dysfunction and hyperandrogenism. It is considered the most common endocrinological disorder, affecting up to 25% of women of reproductive age, and associated with long-term metabolic abnormalities predisposing to cardiovascular risk, such as insulin resistance (IR), dyslipidemia, endothelial dysfunction, and systemic inflammation. PCOS is also characterized by elevated serum levels of luteinizing hormone (LH), causing a condition of hyperandrogenism and a consequent altered ratio between LH and the follicle stimulating hormone (FSH). Over the years, several different approaches have been proposed to alleviate PCOS symptoms. Supplementation with natural molecules such as inositols, resveratrol, flavonoids and flavones, vitamin C, vitamin E and vitamin D, and omega-3 fatty acids may contribute to overcoming PCOS pathological features, including the presence of immature oocyte, IR, hyperandrogenism, oxidative stress and inflammation. This review provides a comprehensive overview of the current knowledge about the efficacy of natural molecule supplementation in the management of PCOS.<\/jats:p>","DOI":"10.3390\/nu13051677","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T02:31:34Z","timestamp":1621218694000},"page":"1677","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Natural Molecules in the Management of Polycystic Ovary Syndrome (PCOS): An Analytical Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Matteo","family":"Iervolino","sequence":"first","affiliation":[{"name":"R&amp;D Department, Lo.Li. Pharma Srl, 00156 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Lepore","sequence":"additional","affiliation":[{"name":"R&amp;D Department, Lo.Li. Pharma Srl, 00156 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpiero","family":"Forte","sequence":"additional","affiliation":[{"name":"R&amp;D Department, Lo.Li. Pharma Srl, 00156 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1543-2802","authenticated-orcid":false,"given":"Antonio Simone","family":"Lagan\u00e0","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cFilippo Del Ponte\u201d Hospital, University of Insubria, 2100 Varese, Italy"},{"name":"The Experts Group on Inositol in Basic and Clinical Research (EGOI), 00156 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9466-0178","authenticated-orcid":false,"given":"Giovanni","family":"Buzzaccarini","sequence":"additional","affiliation":[{"name":"Unit of Gynecology and Obstetrics, Department of Women and Children\u2019s Health, University of Padua, 35128 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Unfer","sequence":"additional","affiliation":[{"name":"The Experts Group on Inositol in Basic and Clinical Research (EGOI), 00156 Rome, Italy"},{"name":"Systems Biology Group Lab, Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/09513590701672405","article-title":"Myo-inositol in patients with polycystic ovary syndrome: A novel method for ovulation induction","volume":"23","author":"Papaleo","year":"2007","journal-title":"Gynecol. 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