{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:14:54Z","timestamp":1792131294956,"version":"4.4.0"},"reference-count":59,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Preterm birth (PTB) is a major cause of neonatal death and long-term consequences for the newborn. This review aims to update the evidence about the potential benefit of pharmacological supplementation with omega 3 fatty acids during pregnancy on the incidence of PTB. The Medline, Embase, Cochrane Library and Central databases were searched until 28 June 2020 for RCTs in which omega 3 supplementation was used versus placebo to reduce PTB risk. Data from 37 trials were analyzed. We found an 11% reduction in PTB risk (RR(risk ratios), 0.89; 95% CI (confidence intervals), 0.82 to 0.97) in trials using omega 3 supplements versus placebo. Regarding early PTB (ePTB), there was a 27% reduction in the risk of ePTB (RR, 0.73; 95% CI, 0.58 to 0.92). However, after sensitivity analyses, there were no significant differences in PTB and ePTB risk (PTB RR, 0.92; 95% CI, 0.83 to 1.01, ePTB RR, 0.82; 95% CI, 0.61 to 1.09). We conclude that omega 3 supplementation during pregnancy does not reduce the risk of PTB and ePTB. More studies are required to determine the effect of omega 3 supplementations during pregnancy and the risk of detrimental fetal outcomes.<\/jats:p>","DOI":"10.3390\/nu13051704","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T06:01:33Z","timestamp":1621317693000},"page":"1704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Supplementation of Omega 3 during Pregnancy and the Risk of Preterm Birth: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"given":"Ram\u00f3n","family":"Serra","sequence":"first","affiliation":[{"name":"Hospital FF.AA Cirujano Guzm\u00e1n, Punta Arenas 6212631, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-1208","authenticated-orcid":false,"given":"Reyna","family":"Pe\u00f1ailillo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Laboratory of Reproduction, Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara J.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Laboratory of Reproduction, Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Monckeberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Laboratory of Reproduction, Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Laboratory of Reproduction, Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1998-8971","authenticated-orcid":false,"given":"L\u00eda","family":"Moyano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Laboratory of Reproduction, Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-9749","authenticated-orcid":false,"given":"Camila","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Laboratory of Reproduction, Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Vega","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Laboratory of Reproduction, Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Choolani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"},{"name":"Department of Obstetrics &amp; Gynaecology, National University Hospital, Singapore 119228, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5433-9315","authenticated-orcid":false,"given":"Sebasti\u00e1n E.","family":"Illanes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Laboratory of Reproduction, Universidad de los Andes, Santiago 7620001, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/S0140-6736(12)60820-4","article-title":"National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: A systematic analysis and implications","volume":"379","author":"Blencowe","year":"2012","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4755-10-S1-S2","article-title":"Born Too Soon: The global epidemiology of 15 million preterm births Understanding the data Preterm birth\u2014What is it? 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