{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:02:56Z","timestamp":1790542976820,"version":"4.1.0"},"reference-count":62,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Southern Queensland","award":["SRF-09"],"award-info":[{"award-number":["SRF-09"]}]},{"name":"Pacific Biotechnology (previously MBD Industries Ltd) Research and Development program for the Integrated Production of Macroalgae","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Entrepreneurial Universities Macroalgal Biotechnologies Programme, jointly funded by the University of Waikato and the Tertiary Education Commission (TEC)","award":["unknown"],"award-info":[{"award-number":["unknown"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The therapeutic potential of Sargassum siliquosum grown in Australian tropical waters was tested in a rat model of metabolic syndrome. Forty-eight male Wistar rats were divided into four groups of 12 rats and each group was fed a different diet for 16 weeks: corn starch diet (C); high-carbohydrate, high-fat diet (H) containing fructose, sucrose, saturated and trans fats; and C or H diets with 5% S. siliquosum mixed into the food from weeks 9 to 16 (CS and HS). Obesity, hypertension, dyslipidaemia, impaired glucose tolerance, fatty liver and left ventricular fibrosis developed in H rats. In HS rats, S. siliquosum decreased body weight (H, 547 \u00b1 14; HS, 490 \u00b1 16 g), fat mass (H, 248 \u00b1 27; HS, 193 \u00b1 19 g), abdominal fat deposition and liver fat vacuole size but did not reverse cardiovascular and liver effects. H rats showed marked changes in gut microbiota compared to C rats, while S. siliquosum supplementation increased gut microbiota belonging to the family Muribaculaceae. This selective increase in gut microbiota likely complements the prebiotic actions of the alginates. Thus, S. siliquosum may be a useful dietary additive to decrease abdominal and liver fat deposition.<\/jats:p>","DOI":"10.3390\/nu13061754","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:01:20Z","timestamp":1621814480000},"page":"1754","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Brown Seaweed Sargassum siliquosum as an Intervention for Diet-Induced Obesity in Male Wistar Rats"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2164-0819","authenticated-orcid":false,"given":"Ryan","family":"du Preez","sequence":"first","affiliation":[{"name":"Functional Foods Research Group, University of Southern Queensland, Toowoomba, QLD 4350, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3141-8544","authenticated-orcid":false,"given":"Marie","family":"Magnusson","sequence":"additional","affiliation":[{"name":"School of Science, Environmental Research Institute, University of Waikato, Tauranga 3112, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6461-8211","authenticated-orcid":false,"given":"Marwan E.","family":"Majzoub","sequence":"additional","affiliation":[{"name":"Centre for Marine Science and Innovation, University of New South Wales, Sydney, NSW 2052, Australia"},{"name":"School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Thomas","sequence":"additional","affiliation":[{"name":"Centre for Marine Science and Innovation, University of New South Wales, Sydney, NSW 2052, Australia"},{"name":"School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Praeger","sequence":"additional","affiliation":[{"name":"MACRO\u2014The Centre for Macroalgal Resources and Biotechnology, College of Marine and Environmental Sciences, James Cook University, Townsville, QLD 4811, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R. 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