{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:54:47Z","timestamp":1772762087493,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ZAMBON S.A.U.","award":["financial support from ZAMBON S.A.U. for the writing of the manuscript"],"award-info":[{"award-number":["financial support from ZAMBON S.A.U. for the writing of the manuscript"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iron deficiency anemia (IDA) is a common manifestation of Inflammatory Bowel Disease (IBD). Oral iron supplements are the treatment of choice, but are not always well tolerated. Sucrosomial\u00ae iron (SI) may represent an alternative. This prospective study assessed the tolerability and effectiveness of SI, and quality of life (QoL) of IDA-IBD patients who were intolerant to oral iron salts. The study included 52 individuals treated with 1 capsule\/day for 12 weeks. Tolerability was assessed through a gastrointestinal symptom severity questionnaire. Hemoglobin (Hb) levels and clinical symptoms of IDA were analyzed. QoL was assessed using IBDQ-9 and EuroQoL questionnaires. The percentage of patients with excellent\/good health increased from 42.9% to 94.3%. Mean Hb concentration significantly increased at all follow-up visits (p &lt; 0.05). Almost all participants (96.9%) were adherent to the study medication. Patients\u2019 QoL improved (IBDQ-9: from 60.9 to 65.5). Patients also improved in mobility (71.8% to 78.1%), usual activities (51.3% to 68.7%), pain\/discomfort (41.0% to 53.1%), and extreme depression\/anxiety problems (7.7% to 3.2%); they worsened in self-care (100% to 90.6%), but perceived an enhancement in their global health [EQ-VAS score: 61.9 (\u00b126.1) to 66.9 (\u00b120.3)]. SI was well tolerated and improved IDA symptoms, IBD activity, and patients\u2019 QoL. In conclusion, SI should be considered in IDA\u2013IBD patients.<\/jats:p>","DOI":"10.3390\/nu13061770","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:01:20Z","timestamp":1621814480000},"page":"1770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sucrosomial Iron Supplementation for the Treatment of Iron Deficiency Anemia in Inflammatory Bowel Disease Patients Refractory to Oral Iron Treatment"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7544-451X","authenticated-orcid":false,"given":"Guillermo","family":"Bastida","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, CIBEREHD, Hospital Universitari i Polit\u00e8cnic La Fe, 46026 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Herrera-de Guise","sequence":"additional","affiliation":[{"name":"Crohn-Colitis Care Unit, Vall d\u2019Hebron Hospital Universitari, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Algaba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Instituto de Investigaci\u00f3n Sanitaria Hospital La Paz (IdiPaz), Hospital Universitario de Fuenlabrada, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5184-8349","authenticated-orcid":false,"given":"Yolanda","family":"Ber Nieto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitario San Jorge, 22004 Huesca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Manuel","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Pedro Hispano, 4454-509 Matosinhos, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Robles","sequence":"additional","affiliation":[{"name":"Crohn-Colitis Care Unit, Vall d\u2019Hebron Hospital Universitari, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Bermejo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Instituto de Investigaci\u00f3n Sanitaria Hospital La Paz (IdiPaz), Hospital Universitario de Fuenlabrada, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9042-2308","authenticated-orcid":false,"given":"Esteban","family":"S\u00e1ez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CIBEREHD, Hospital Universitari i Polit\u00e8cnic La Fe, 46026 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0076-3529","authenticated-orcid":false,"given":"Fernando","family":"Gomoll\u00f3n","sequence":"additional","affiliation":[{"name":"IBD Unit, Digestive Diseases Service, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS), CIBEREHD, Hospital Cl\u00ednico Universitario \u201cLozano Blesa\u201d, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6619-1511","authenticated-orcid":false,"given":"Pilar","family":"Nos","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, CIBEREHD, Hospital Universitari i Polit\u00e8cnic La Fe, 46026 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/apt.12541","article-title":"The IBSEN Study Group Anaemia in inflammatory bowel disease: A population-based 10-year follow-up","volume":"39","author":"Reinisch","year":"2014","journal-title":"Aliment. 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