{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T21:41:22Z","timestamp":1764020482969,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012514","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red-Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n","doi-asserted-by":"publisher","award":["CB06\/03\/1012"],"award-info":[{"award-number":["CB06\/03\/1012"]}],"id":[{"id":"10.13039\/501100012514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-104915RB-I00","SAF2016-75441-R"],"award-info":[{"award-number":["PID2019-104915RB-I00","SAF2016-75441-R"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag\u00f3n","doi-asserted-by":"publisher","award":["B16_20R"],"award-info":[{"award-number":["B16_20R"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background and aim: The type and amount of dietary protein has become a topic of renewed interest in light of their involvement in metabolic diseases, atherosclerosis and thrombosis. However, little attention has been devoted to the effect of avian proteins despite their wide human consumption. The aim was to investigate the influence of chicken and turkey as sources of protein compared with that of soybean on atherosclerosis and fatty liver disease. Methods and results: To this purpose, male and female Apoe-deficient were fed purified Western diets differing in their protein sources for 12 weeks. After this period, blood, liver, aortic tree and heart base samples were taken for analyses of plasma lipids and atherosclerosis. Plasma triglycerides, non-esterified fatty acids, esterified cholesterol levels and radical oxygen species in lipoproteins changed depending on the diet and sex. Females consuming the turkey protein-containing diet showed decreased atherosclerotic foci, as evidenced by the en face atherosclerosis analyses. The presence of macrophages and smooth muscle cells in plaques were not modified, and no changes were observed in hepatic lipid droplets in the studied groups either. Paraoxonase activity was higher in the group consuming turkey protein without sex differences, but only in females, it was significantly associated with aortic lesion areas. Conclusions: Compared to soybean protein, the consumption of avian proteins depending on sex resulted in similar or lower atherosclerosis development and comparable hepatic steatosis.<\/jats:p>","DOI":"10.3390\/nu13061838","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T11:07:02Z","timestamp":1622113622000},"page":"1838","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dietary Avian Proteins Are Comparable to Soybean Proteins on the Atherosclerosis Development and Fatty Liver Disease in Apoe-Deficient Mice"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8100-5596","authenticated-orcid":false,"given":"Roberto","family":"Mart\u00ednez-Beamonte","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Facultad de Veterinaria, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Universidad de Zaragoza, E-50013 Zaragoza, Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III, E-28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9023-741X","authenticated-orcid":false,"given":"Javier","family":"S\u00e1nchez-Marco","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Facultad de Veterinaria, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Universidad de Zaragoza, E-50013 Zaragoza, Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Facultad de Veterinaria, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Universidad de Zaragoza, E-50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Barco","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Facultad de Veterinaria, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Universidad de Zaragoza, E-50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Herrero-Continente","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Facultad de Veterinaria, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Universidad de Zaragoza, E-50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Serrano-Meg\u00edas","sequence":"additional","affiliation":[{"name":"Aves Nobles y Derivados-Aldelis, E-50197 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Botaya","sequence":"additional","affiliation":[{"name":"Aves Nobles y Derivados-Aldelis, E-50197 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Arnal","sequence":"additional","affiliation":[{"name":"Instituto Agroalimentario de Arag\u00f3n, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III, E-28029 Madrid, Spain"},{"name":"Departamento de Patolog\u00eda Animal, Facultad de Veterinaria, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Universidad de Zaragoza, E-50013 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Barranquero","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Facultad de Veterinaria, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Universidad de Zaragoza, E-50013 Zaragoza, Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III, E-28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Surra","sequence":"additional","affiliation":[{"name":"Instituto Agroalimentario de Arag\u00f3n, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III, E-28029 Madrid, Spain"},{"name":"Departamento de Producci\u00f3n Animal y Ciencia de los Alimentos, Escuela Polit\u00e9cnica Superior de Huesca, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Universidad de Zaragoza, E-22071 Huesca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-8457","authenticated-orcid":false,"given":"Jes\u00fas","family":"Osada","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Celular, Facultad de Veterinaria, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Universidad de Zaragoza, E-50013 Zaragoza, Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n, CITA-Universidad de Zaragoza, E-50013 Zaragoza, Spain"},{"name":"CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n, Instituto de Salud Carlos III, E-28029 Madrid, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Veterinary School, University of Zaragoza, Miguel Servet, 177, E-50013 Zaragoza, 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