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As an established risk factor for numerous comorbidities with a multifactorial etiology, obesity is a consequence of energy-dense overfeeding, however with significant undernourishment, leading to excessive adipose tissue accumulation and dysfunction, dyslipidemia, and micronutrient deficiencies. About 60% of patients with obesity take statins, a cholesterol-lowering medication, to curb dyslipidemia, with ~10% of these patients presenting various myopathies as side effects. Statins act upon the rate-limiting enzyme of cholesterol biosynthesis in the liver, which is a pathway providing intermediates to the synthesis of selenoproteins, i.e., enzymes containing the micronutrient selenium. Statins have been postulated to negatively impact selenoprotein synthesis, particularly in conditions of selenium deficiency, and potentially implicated in the myopathies occurring as side effects of statins. The Brazilian population is prone to selenium deficiency, hence could be considered more susceptible to statin side effects. This review examines the specific consequences to the Brazilian population of the harmful intersection between obesity development and concomitant micronutrient deficiencies, particularly selenium, combined with statin treatment in the context of nutrition in Brazil.<\/jats:p>","DOI":"10.3390\/nu13062027","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T22:25:46Z","timestamp":1623709546000},"page":"2027","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Intersection between Obesity, Dietary Selenium, and Statin Therapy in Brazil"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7498-6165","authenticated-orcid":false,"given":"Ligia M.","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Division of Nutrition and Metabolism, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2014FMRP\/USP, Ribeir\u00e3o Preto 14040-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-3001","authenticated-orcid":false,"given":"Anderson M.","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Division of Nutrition and Metabolism, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo\u2014FMRP\/USP, Ribeir\u00e3o Preto 14040-900, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0686-7516","authenticated-orcid":false,"given":"Lucia A.","family":"Seale","sequence":"additional","affiliation":[{"name":"Pacific Biosciences Research Center, School of Ocean and Earth Science and Technology, University of Hawaii at Manoa, Honolulu, HI 96822, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejim.2017.10.020","article-title":"Obesity Phenotypes and Their Paradoxical Association with Cardiovascular Diseases","volume":"48","author":"Dallegri","year":"2018","journal-title":"Eur. 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