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However, there is a lack of literature examining the potential role of weight course as a transdiagnostic factor in ED so far. Therefore, the aim of this study is to compare ED severity and treatment outcomes among four specific BMI profiles based on BMI-trajectories across the lifespan: (a) persistent obesity (OB-OB; (n = 74)), (b) obesity in the past but currently in a normal weight range (OB-NW; n = 156), (c) normal weight throughout the lifespan (NW-NW; n = 756), and (d) current obesity but previously at normal weight (NW-OB; n = 314). Lifetime obesity is associated with greater general psychopathology and personality traits such as low persistence and self-directedness, and high reward dependence. Additionally, greater extreme weight changes (NW-OB and OB-NW) were associated with higher psychopathology but not with greater ED severity. Higher dropout rates were found in the OB-OB group. These results shed new light on the BMI trajectory as a transdiagnostic feature playing a pivotal role in the severity and treatment outcome in patients with ED.<\/jats:p>","DOI":"10.3390\/nu13062034","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T22:25:46Z","timestamp":1623709546000},"page":"2034","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lifetime Weight Course as a Phenotypic Marker of Severity and Therapeutic Response in Patients with Eating Disorders"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4453-4939","authenticated-orcid":false,"given":"Zaida","family":"Ag\u00fcera","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III, 08907 L\u2019Hospitalet de Llobregat, Spain"},{"name":"Department of Psychiatry, University Hospital of Bellvitge, 08907 L\u2019Hospitalet de Llobregat, Spain"},{"name":"Psychiatry and Mental Health Group, Neuroscience Program, Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge\u2014IDIBELL, 08907 L\u2019Hospitalet de Llobregat, Spain"},{"name":"Department of Public Health, Mental Health and Maternal-Child Nursing, School of Nursing, University of Barcelona, 08907 L\u2019Hospitalet de Llobregat, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-8810","authenticated-orcid":false,"given":"Cristina","family":"Vintr\u00f3-Alcaraz","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fisiopatolog\u00eda Obesidad y Nutrici\u00f3n (CIBERobn), Instituto de Salud Carlos III, 08907 L\u2019Hospitalet de Llobregat, Spain"},{"name":"Department of Psychiatry, University Hospital of Bellvitge, 08907 L\u2019Hospitalet de Llobregat, 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