{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:35:30Z","timestamp":1788690930029,"version":"build-2803163510"},"reference-count":163,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work was supported by a grant from the Romanian Ministry of Education and Research, CNCS - UEFISCDI,","award":["PN-III-P1-1.1-PD-2019-0475, within PNCDI III"],"award-info":[{"award-number":["PN-III-P1-1.1-PD-2019-0475, within PNCDI III"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Human skin acts as a physical barrier; however, sometimes the skin gets infected by fungi, which becomes more severe if the infection occurs on the third layer of the skin. Azole derivative-based antifungal creams, liquids, or sprays are available to treat fungal infections; however, these formulations show various side effects on the application site. Over the past few years, herbal extracts and various essential oils have shown effective antifungal activity. Additionally, autoxidation and epimerization are significant problems with the direct use of herbal extracts. Hence, to overcome these obstacles, polysaccharide-based nanohydrogels embedded with natural plant extracts and oils have become the primary choice of pharmaceutical scientists. These gels protect plant-based bioactive compounds and are effective delivery agents because they release multiple bioactive compounds in the targeted area. Nanohydrogels can be applied to infected areas, and due to their contagious nature and penetration power, they get directly absorbed through the skin, quickly reaching the skin\u2019s third layer and effectively reducing the fungal infection. In this review, we explain various skin fungal infections, possible treatments, and the effective utilization of plant extract and oil-embedded polysaccharide-based nanohydrogels.<\/jats:p>","DOI":"10.3390\/nu13062055","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T21:24:29Z","timestamp":1623792269000},"page":"2055","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["A Review on Antifungal Efficiency of Plant Extracts Entrenched Polysaccharide-Based Nanohydrogels"],"prefix":"10.3390","volume":"13","author":[{"given":"Navkiranjeet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Food Technology and Nutrition, Lovely Professional University, Phagwara 144411, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarti","family":"Bains","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chandigarh Group of Colleges Landran, Mohali 140307, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Kaushik","sequence":"additional","affiliation":[{"name":"School of Health Sciences, University of Petroleum and Energy Studies, Dehradun 248007, Uttrakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5749-6241","authenticated-orcid":false,"given":"Sanju B.","family":"Dhull","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Chaudhary Devi Lal University, Sirsa 125055, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9561-1183","authenticated-orcid":false,"given":"Fogarasi","family":"Melinda","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Calea M\u0103n\u0103stur 3\u20135, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2383-7925","authenticated-orcid":false,"given":"Prince","family":"Chawla","sequence":"additional","affiliation":[{"name":"Department of Food Technology and Nutrition, Lovely Professional University, Phagwara 144411, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/7651810","article-title":"Fabrication of an Original Transparent PVA\/Gelatin Hydrogel: In Vitro Antimicrobial Activity against Skin Pathogens","volume":"2019","author":"Imtiaz","year":"2019","journal-title":"Int. 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