{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:36:10Z","timestamp":1793835370182,"version":"4.6.1"},"reference-count":69,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T00:00:00Z","timestamp":1624147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The burden of cognitive disorders is huge and still growing, however the etiology and the degree of cognitive impairment vary considerably. Neurodegenerative and vascular mechanisms were most frequently assessed in patients with dementia. Recent studies have shown the possible involvement of triglycerides levels in cognitive function through putative mechanisms such as brain blood barrier dysfunction or amyloid metabolism imbalance, but not all research in the field found this association. Several clinical studies evaluated the relationship between different forms of cognitive decline and levels of serum triglycerides, independent of other cardiovascular risk factors. This review focuses on the role of triglycerides in cognitive decline, cerebral amyloidosis and vascular impairment. Considering that the management of hypertriglyceridemia benefits from lifestyle modification, diet, and specific drug therapy, future studies are requested to appraise the triglycerides\u2013cognitive impairment relationship.<\/jats:p>","DOI":"10.3390\/nu13062118","type":"journal-article","created":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T21:50:15Z","timestamp":1624225815000},"page":"2118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence"],"prefix":"10.3390","volume":"13","author":[{"given":"Alina Mihaela","family":"Dimache","sequence":"first","affiliation":[{"name":"Neurology Outpatient Clinic, Department of Chronic Diseases, Hospital of Chronic Diseases T\u00e2rgu Frumos, 705300 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia Lidia","family":"\u0218alaru","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Ia\u0219i, Romania"},{"name":"Institute of Cardiovascular Diseases, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Sasc\u0103u","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Ia\u0219i, Romania"},{"name":"Institute of Cardiovascular Diseases, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-4561","authenticated-orcid":false,"given":"Cristian","family":"St\u0103tescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Medicine and Pharmacy Grigore T. Popa, 700115 Ia\u0219i, Romania"},{"name":"Institute of Cardiovascular Diseases, 700503 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.arr.2013.06.004","article-title":"Frailty and cognitive impairment\u2014A review of the evidence and causal mechanisms","volume":"12","author":"Robertson","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"ref_2","unstructured":"Prince, M.W.A., Guerchet, M., Ali, G.C., Wu, Y.T., and Prina, M. (2015). World Alzheimer Report 2015\u2014The Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends, Alzheimer\u2019s Disease International."},{"key":"ref_3","unstructured":"World Health Organization (2021, April 15). Dementia: A Public Health Priority. 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