{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:24:57Z","timestamp":1775078697101,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD16\/0006\/0013"],"award-info":[{"award-number":["RD16\/0006\/0013"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: Allergy to nonspecific lipid transfer protein (nsLTP) is the main cause of plant-food allergy in Spain. nsLTPs are widely distributed in the plant kingdom and have high cross-reactivity but extremely variable clinical expression. Little is known about the natural evolution of this allergy, which complicates management. The objective of this study was to assess the development of allergy to new plant foods in nsLTP-sensitized patients 10 years after diagnosis. Methods: One hundred fifty-one patients showing specific IgE to nsLTP determined by ISAC (Thermofisher) were included. After clinical workup (i.e., anamnesis, skin test, and challenge when needed), these patients were divided into two groups: 113 patients allergic to one or more plant food (74.5%) and 38 patients not allergic to any plant food (25.1%). Ten years later, a telephone interview was conducted to check whether patients had developed additional allergic reactions to plant foods. Results: Ten years after diagnosis, 35 of the 113 (31%) plant-food-allergic patients sensitized to nsLTP reported reactions to new, previously tolerated plant foods, mainly Rosaceae\/Prunoideae fruits and nuts followed by vegetables, Rosacea\/Pomoideae fruits, legumes, and cereals. Five out of 38 (13.2%) patients previously sensitized to nsLTP but without allergy to any plant food had experienced allergic reactions to some plant food: two to Rosaceae\/Prunoideae fruits, two to Rosaceae\/Prunoideae fruit and nuts, and one to legumes. Conclusion: Patients sensitized to nsLTP developed allergic reactions to other plant foods, mainly Rosaceae-Prunoideae fruits and nuts. This was more frequent among plant-food-allergic patients than among those who had never had plant-food allergy.<\/jats:p>","DOI":"10.3390\/nu13072165","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T04:24:36Z","timestamp":1624508676000},"page":"2165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later"],"prefix":"10.3390","volume":"13","author":[{"given":"Diana","family":"Betancor","sequence":"first","affiliation":[{"name":"Department of Allergy, Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS-FJD, UAM), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Gomez-Lopez","sequence":"additional","affiliation":[{"name":"Department of Allergy, Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS-FJD, UAM), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Villalobos-Vilda","sequence":"additional","affiliation":[{"name":"Department of Allergy, Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS-FJD, UAM), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Nu\u00f1ez-Borque","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS-FJD, UAM), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Fern\u00e1ndez-Bravo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS-FJD, UAM), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"De las Heras Gozalo","sequence":"additional","affiliation":[{"name":"Department of Allergy, Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS-FJD, UAM), 28040 Madrid, Spain"},{"name":"RETIC ARADyAL, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4678-7967","authenticated-orcid":false,"given":"Carlos","family":"Pastor-Vargas","sequence":"additional","affiliation":[{"name":"RETIC ARADyAL, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-6277","authenticated-orcid":false,"given":"Vanesa","family":"Esteban","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS-FJD, UAM), 28040 Madrid, Spain"},{"name":"RETIC ARADyAL, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Faculty of Medicine and Biomedicine, Alfonso X El Sabio University, Villanueva de la Ca\u00f1ada, 28691 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Cuesta-Herranz","sequence":"additional","affiliation":[{"name":"Department of Allergy, Instituto de Investigaci\u00f3n Sanitaria Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (IIS-FJD, UAM), 28040 Madrid, Spain"},{"name":"RETIC ARADyAL, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/j.jaip.2019.02.044","article-title":"Food Allergy in Adults: Substantial Variation in Prevalence and Causative Foods Across Europe","volume":"7","author":"Lyons","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1111\/all.14447","article-title":"Phenotyping peach-allergic patients sensitized to lipid transfer protein and analysing severity biomarkers","volume":"75","author":"Bogas","year":"2020","journal-title":"Allergy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1021\/acs.jafc.0c06949","article-title":"IgE-reactivity pattern of tomato seed and peel nonspecific Lipid-Transfer Proteins after in vitro gastrointestinal digestion","volume":"69","author":"Mayorga","year":"2021","journal-title":"Agric. Food Chem."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Skypala, I.J., Bartra, J., Ebo, D.G., Faber, M.A., Fern\u00e1ndez-Rivas, M., Gomez, F., Luengo, O., Till, S.J., Asero, R., and Barber, D. (2021). The diagnosis and management of allergic reactions in patients sensitized to non-specific lipid transfer proteins. Allergy.","DOI":"10.1111\/all.14797"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.jaci.2010.09.010","article-title":"Peanut allergy: Clinical and immunologic differences among patients from 3 different geographic regions","volume":"127","author":"Vereda","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Haroun-D\u00edaz, E., Azofra, J., Gonz\u00e1lez-Mancebo, E., Heras, M.D.L., Pastor-Vargas, C., Esteban, V., Villalba, M., D\u00edaz-Perales, A., and Cuesta-Herranz, J. (2017). Nut Allergy in Two Different Areas of Spain: Differences in Clinical and Molecular Pattern. Nutrients, 9.","DOI":"10.3390\/nu9080909"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1111\/all.13151","article-title":"Pru p 3, a marker allergen for lipid transfer protein sensitization also in Central Europe","volume":"72","author":"Raith","year":"2017","journal-title":"Allergy"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000222679","article-title":"Causes of food-induced anaphylaxis in Italian adults: A mul-ti-centre study","volume":"150","author":"Asero","year":"2009","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1046\/j.1365-2222.2000.00868.x","article-title":"Allergy to plant-derived fresh foods in a birch- and ragweed-free area","volume":"30","author":"Figueredo","year":"2000","journal-title":"Clin. Exp. Allergy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.5415\/apallergy.2016.6.2.129","article-title":"A case study of apple seed and grape allergy with sensitisation to nonspecific lipid transfer protein","volume":"6","author":"Murad","year":"2016","journal-title":"Asia Pac. Allergy"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jaci.2012.07.015","article-title":"Peach allergy in China: A dominant role for mugwort pollen lipid transfer protein as a primary sensitizer","volume":"131","author":"Gao","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jaci.2016.06.016","article-title":"IgE-reactivity profiles to nonspecific lipid transfer proteins in a northwestern Eu-ropean country","volume":"139","author":"Faber","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/j.1365-2222.2012.04071.x","article-title":"Lipid transfer protein syndrome: Clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens","volume":"42","author":"Pascal","year":"2012","journal-title":"Clin. Exp. Allergy"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1056\/NEJMoa1414850","article-title":"LEAP Study Team. Randomized trial of peanut consumption in infants at risk for peanut allergy","volume":"372","author":"Roberts","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S0140-6736(13)62301-6","article-title":"Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): A phase 2 randomised controlled trial","volume":"383","author":"Anagnostou","year":"2014","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/cea.12901","article-title":"The clinical and immunological efects of Pru p 3 sublingual immunotherapy on peach and peanut allergy in patients with systemic reactions","volume":"47","author":"Gomez","year":"2017","journal-title":"Clin. Exp. Allergy"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13601-020-00325-y","article-title":"Pru p 3 oral immuno-therapy eficacy, induced immunological changes and quality of life improvement in patients with LTP syndrome","volume":"10","year":"2020","journal-title":"Clin. Transl. Allergy"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1159\/000512613","article-title":"Pru p 3 Sublingual Immunotherapy in Patients with Lipid Transfer Protein Syndrome: Is It Worth?","volume":"182","author":"Beitia","year":"2021","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.23822\/EurAnnACI.1764-1489.57","article-title":"Allergy to LTP: To eat or not to eat sensitizing foods? A follow-up study","volume":"50","author":"Asero","year":"2018","journal-title":"Eur. Ann. Allergy Clin. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/all.12635","article-title":"Lipid transfer protein sensitization: Reactivity profiles and clinical risk assessment in an Italian cohort","volume":"70","author":"Scala","year":"2015","journal-title":"Allergy"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1159\/000324440","article-title":"Pru p 3-sensitised Italian peach-allergic patients are less likely to develop severe symptoms when also presenting IgE antibodies to Pru p 1 and Pru p 4","volume":"156","author":"Pastorello","year":"2011","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1111\/all.13501","article-title":"Cosensitization to profilin is associat-ed with less severe reactions to foods in nsLTPs and storage proteins reactors and with less severe respiratory allergy","volume":"73","author":"Scala","year":"2018","journal-title":"Allergy"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jaci.2004.06.020","article-title":"Lipid transfer protein and vicilin are important walnut allergens in patients not allergic to pollen","volume":"114","author":"Pastorello","year":"2004","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/7\/2165\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:22:40Z","timestamp":1760163760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/7\/2165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,24]]},"references-count":23,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["nu13072165"],"URL":"https:\/\/doi.org\/10.3390\/nu13072165","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,24]]}}}