{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:19:28Z","timestamp":1771867168736,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2018\/29\/B\/NZ9\/00461"],"award-info":[{"award-number":["2018\/29\/B\/NZ9\/00461"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Because the world\u2019s population is deficient in dietary calcium, it is important to search for new sources of this essential mineral for the bones and the entire body. One of the innovative foods that could act as such a source is pumpkin enriched with calcium lactate by means of osmotic dehydration. Providing the body with easily absorbable calcium may have beneficial effects on the reconstruction of bone tissue. Postmenopausal osteoporosis is associated with body weight and fat mass gain, and the aim of the present study was to evaluate the effect of consuming enriched pumpkin on the levels of adipokines and cytokines produced by the adipose tissue. This study was conducted on 12-month-old female Wistar rats that received nutritional intervention for 12 weeks. After termination of the rats, the levels of leptin, adiponectin, interleukin 31 and interleukin 33 in serum and adipose tissue were determined, and the femurs were examined histopathologically. It was demonstrated that calcium-enriched pumpkin reduced bone marrow femoral adipocytes and also markedly decreased serum leptin levels in groups of rats after ovariectomy, which was associated with a decrease of fat content. Additionally, it seems that calcium-enriched pumpkin may reduce body weight gain often observed after menopause.<\/jats:p>","DOI":"10.3390\/nu13072334","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T10:42:17Z","timestamp":1625740937000},"page":"2334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Calcium-Enriched Pumpkin Affects Serum Leptin Levels and Fat Content in a Rat Model of Postmenopausal Osteoporosis"],"prefix":"10.3390","volume":"13","author":[{"given":"Natalia","family":"Wawrzyniak","sequence":"first","affiliation":[{"name":"Department of Human Nutrition and Dietetics, Faculty of Food Science and Nutrition, Pozna\u0144 University of Life Sciences, Wojska Polskiego 31, 60-624 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0937-8427","authenticated-orcid":false,"given":"Joanna","family":"Suliburska","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Dietetics, Faculty of Food Science and Nutrition, Pozna\u0144 University of Life Sciences, Wojska Polskiego 31, 60-624 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9620-7852","authenticated-orcid":false,"given":"Bartosz","family":"Kulczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Gastronomy Science and Functional Foods, Faculty of Food Science and Nutrition, Pozna\u0144 University of Life Sciences, Wojska Polskiego 31, 60-624 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-0223","authenticated-orcid":false,"given":"Pawe\u0142","family":"Ko\u0142odziejski","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology, Biochemistry and Biostructure, Faculty of Veterinary Medicine and Animal Science, Pozna\u0144 University of Life Sciences, Wojska Polskiego 28, 60-637 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-0291","authenticated-orcid":false,"given":"Pawe\u0142","family":"Kurzawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Pozna\u0144 University of Medical Sciences, Przybyszewskiego 49, 60-355 Pozna\u0144, Poland"},{"name":"Department of Oncological Pathology, University Hospital of Lord\u2019s Transfiguration, Partner of Karol Marcinkowski University of Medical Sciences, Szamarzewskiego 84, 60-569 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-9033","authenticated-orcid":false,"given":"Anna","family":"Gramza-Micha\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Gastronomy Science and Functional Foods, Faculty of Food Science and Nutrition, Pozna\u0144 University of Life Sciences, Wojska Polskiego 31, 60-624 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.beem.2018.09.005","article-title":"Postmenopausal osteoporosis: Assessment and management","volume":"32","author":"Rizzoli","year":"2018","journal-title":"Best Pract. 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