{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T18:42:08Z","timestamp":1773513728010,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Swedish Asthma and Allergy research foundation","award":["F2017-0007"],"award-info":[{"award-number":["F2017-0007"]}]},{"name":"the Swedish Research Council for Health, Working Life and Welfare","award":["2010-00451, 2017-00526"],"award-info":[{"award-number":["2010-00451, 2017-00526"]}]},{"name":"Swedish Heart-Lung Foundation","award":["20180579"],"award-info":[{"award-number":["20180579"]}]},{"name":"the European Research Council","award":["757919"],"award-info":[{"award-number":["757919"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Food hypersensitivity (FHS) refers to food-related symptoms, with or without concurrent Immunoglobulin E (IgE) antibodies related to food(s). It remains unclear how different FHS phenotypes affect health-related quality of life (HRQoL). We examined self-reported HRQoL (with the generic instrument EQ-5D (dimensions and a Visual Analogue Scale (VAS), range 0\u2013100) in association with phenotypes of FHS, and food-specific symptoms among adolescents (n = 2990) from a population-based birth cohort. Overall, 22% of the adolescents had FHS. Compared to adolescents without FHS, those with FHS reported more problems in the dimensions of pain\/discomfort (p &lt; 0.001), and anxiety\/depression (p = 0.007). Females with FHS reported more problems than males in these dimensions (p &lt; 0.001). Different FHS phenotypes (IgE-sensitization, allergic co-morbidity, and severity of symptoms) were not associated with differences in HRQoL. EQ-VAS scores were lowest for adolescents with symptoms for wheat vs. no wheat, median 80 vs. 89, p = 0.04) and milk vs. no milk (median 85 vs. 90, p = 0.03). Physician-diagnosed lactose intolerance median EQ-VAS was 80 vs. 90, p = 0.03 and also associated with more problems in the dimension of anxious\/depression. In conclusion, FHS is associated with lower HRQoL in adolescence, irrespective of phenotypes, but differentially affects females vs. males, and those with vs. without symptoms for milk or wheat.<\/jats:p>","DOI":"10.3390\/nu13072357","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T10:50:38Z","timestamp":1625827838000},"page":"2357","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Living with Food Hypersensitivity as an Adolescent Impairs Health Related Quality of Life Irrespective of Disease Severity: Results from a Population-Based Birth Cohort"],"prefix":"10.3390","volume":"13","author":[{"given":"Marina","family":"Jonsson","sequence":"first","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden"},{"name":"Centre for Occupational and Environmental Medicine, Region Stockholm, Solnav\u00e4gen 4, 113 65 Stockholm, Sweden"},{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet, 118 83 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden"},{"name":"Centre for Occupational and Environmental Medicine, Region Stockholm, Solnav\u00e4gen 4, 113 65 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L. P.","family":"Protudjer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3A 1S1, Canada"},{"name":"George and Fay Yee Centre for Healthcare Innovation, Winnipeg, MB R3E 0T6, Canada"},{"name":"The Children\u2019s Hospital Research Institute of Manitoba, Winnipeg, MB R3E 3P4, Canada"},{"name":"The Centre for Allergy Research, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden"},{"name":"Centre for Occupational and Environmental Medicine, Region Stockholm, Solnav\u00e4gen 4, 113 65 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Kull","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education, S\u00f6dersjukhuset, Karolinska Institutet, 118 83 Stockholm, Sweden"},{"name":"Sachs\u2019 Children and Youth Hospital, 118 83 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/all.12423","article-title":"Prevalence of common food allergies in Europe: A systematic review and meta-analysis","volume":"69","author":"Nwaru","year":"2014","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1111\/cea.12984","article-title":"Food allergy phenotypes: The key to personalized therapy","volume":"47","author":"Deschildre","year":"2017","journal-title":"Clin. 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