{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:08:19Z","timestamp":1791083299173,"version":"4.1.0"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T00:00:00Z","timestamp":1626480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003668","name":"Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries","doi-asserted-by":"publisher","award":["319104-04-1-HD030"],"award-info":[{"award-number":["319104-04-1-HD030"]}],"id":[{"id":"10.13039\/501100003668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We examined the immunomodulatory and anti-inflammatory effects of asiatic acid (AA) in atopic dermatitis (AD). AA treatment (5\u201320 \u00b5g\/mL) dose-dependently suppressed the tumor necrosis factor (TNF)-\u03b1 level and interleukin (IL)-6 protein expression in interferon (IFN)-\u03b3 + TNF-\u03b1-treated HaCaT cells. The 2,4-dinitrocholrlbenzene (DNCB)-induced AD animal model was developed by administering two AA concentrations (30 and 75 mg\/kg\/d: AD + AA-L and AD + AA-H groups, respectively) for 18 days. Interestingly, AA treatment decreased AD skin lesions formation and affected other AD characteristics, such as increased ear thickness, lymph node and spleen size, dermal and epidermal thickness, collagen deposition, and mast cell infiltration in dorsal skin. In addition, in the DNCB-induced AD animal model, AA treatment downregulated the mRNA expression level of AD-related cytokines, such as Th1- (TNF-\u03b1 and IL-1\u03b2 and -12) and Th2 (IL-4, -5, -6, -13, and -31)-related cytokines as well as that of cyclooxygenase-2 and CXCL9. Moreover, in the AA treatment group, the protein level of inflammatory cytokines, including COX-2, IL-6, TNF-\u03b1, and IL-8, as well as the NF-\u03baB and MAPK signaling pathways, were decreased. Overall, our study confirmed that AA administration inhibited AD skin lesion formation via enhancing immunomodulation and inhibiting inflammation. Thus, AA can be used as palliative medication for regulating AD symptoms.<\/jats:p>","DOI":"10.3390\/nu13072448","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T21:18:52Z","timestamp":1626643132000},"page":"2448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Immunomodulatory and Anti-inflammatory Effects of Asiatic Acid in a DNCB-Induced Atopic Dermatitis Animal Model"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-1167","authenticated-orcid":false,"given":"Gyo-Ha","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, KC University, Seoul 07661, Korea"},{"name":"Department of Food Science and Technology, Seoul National University of Science & Technology, Seoul 01811, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghyeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, KC University, Seoul 07661, Korea"},{"name":"Department of Food Science and Technology, Seoul National University of Science & Technology, Seoul 01811, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4832-6427","authenticated-orcid":false,"given":"Eun-Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Dong-A University, Busan 49315, Korea"},{"name":"Center for Silver-targeted Biomaterials, Brain Busan 21 Plus program, Dong-A University, Busan 49315, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Hyun","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Seoul National University of Science & Technology, Seoul 01811, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwon-Jai","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of H-LAC, Daejeon University, Daejeon 34520, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2431-144X","authenticated-orcid":false,"given":"Jeung-Hee","family":"An","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, KC University, Seoul 07661, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,17]]},"reference":[{"key":"ref_1","first-page":"2683","article-title":"Role of reactive oxygen species and antioxidants in atopic dermatitis","volume":"7","author":"Sivaranjani","year":"2013","journal-title":"J. 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