{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:31:10Z","timestamp":1790512270906,"version":"4.1.0"},"reference-count":142,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T00:00:00Z","timestamp":1626566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Here we present an extensive narrative review of the broadly understood modifications to the lifestyles of women with polycystic ovary syndrome (PCOS). The PubMed database was analyzed, combining PCOS entries with causes, diseases, diet supplementation, lifestyle, physical activity, and use of herbs. The metabolic pathways leading to disturbances in lipid, carbohydrate, and hormonal metabolism in targeted patients are described. The article refers to sleep disorders, changes in mental health parameters, and causes of oxidative stress and inflammation. These conditions consistently lead to the occurrence of severe diseases in patients suffering from diabetes, the fatty degeneration of internal organs, infertility, atherosclerosis, cardiovascular diseases, dysbiosis, and cancer. The modification of lifestyles, diet patterns and proper selection of nutrients, pharmacological and natural supplementation in the form of herbs, and physical activity have been proposed. The progress and consequences of PCOS are largely modifiable and depend on the patient\u2019s approach, although we have to take into account also the genetic determinants.<\/jats:p>","DOI":"10.3390\/nu13072452","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T21:18:52Z","timestamp":1626643132000},"page":"2452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":144,"title":["Nutrition Strategy and Life Style in Polycystic Ovary Syndrome\u2014Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-0624","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Szczuko","sequence":"first","affiliation":[{"name":"Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Broniewskiego 24 St, 71-460 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Kikut","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Broniewskiego 24 St, 71-460 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Szczuko","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Broniewskiego 24 St, 71-460 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1518-8838","authenticated-orcid":false,"given":"Iwona","family":"Szyd\u0142owska","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1 St, 71-256 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Nawrocka-Rutkowska","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Obstetrics and Gynecology Pomeranian Medical University in Szczecin, Siedlecka 2 St, 72-010 Police, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7729-0670","authenticated-orcid":false,"given":"Maciej","family":"Zi\u0119tek","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Obstetrics and Gynecology Pomeranian Medical University in Szczecin, Siedlecka 2 St, 72-010 Police, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9106-1604","authenticated-orcid":false,"given":"Donatella","family":"Verbanac","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kova\u010di\u0107a 1, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-8706","authenticated-orcid":false,"given":"Luciano","family":"Saso","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cVittorio Erspamer\u201d, Sapienza University, P. le Aldo Moro 5, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on Women\u2019s Health Aspects of Polycystic Ovary Syndrome (PCOS): The Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group","volume":"97","author":"Fauser","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13048-020-00755-z","article-title":"Effects of Exogenous Adiponectin Supplementation in Early Pregnant PCOS Mice on the Metabolic Syndrome of Adult Female Offspring","volume":"14","author":"Zuo","year":"2021","journal-title":"J. Ovarian Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5489523","DOI":"10.1155\/2017\/5489523","article-title":"Significant Improvement Selected Mediators of Inflammation in Phenotypes of Women with PCOS after Reduction and Low GI Diet","volume":"2017","author":"Szczuko","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ma, L., Cao, Y., Ma, Y., and Zhai, J. (2021). Association between hyperandrogenism and adverse pregnancy outcomes in patients with different polycystic ovary syndrome phenotypes undergoing in vitro fertilization\/intracytoplasmic sperm injection: A systematic review and meta-analysis. Gynecol. Endocrinol., 1\u20138.","DOI":"10.1080\/09513590.2021.1897096"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/GRF.0000000000000593","article-title":"Polycystic Ovarian Syndrome: Impact on Adult and Fetal Health","volume":"64","author":"Martini","year":"2021","journal-title":"Clin. Obs. Gynecol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13020-020-00405-y","article-title":"Catechins from Oolong Tea Improve Uterine Defects by Inhibiting STAT3 Signaling in Polycystic Ovary Syndrome Mice","volume":"15","author":"Hong","year":"2020","journal-title":"Chin. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Del Pup, L., and Cagnacci, A. (2021). IMPROVE Lifestyle in Polycystic Ovary Syndrome: A Systematic Strategy. Gynecol. Endocrinol., 1\u20134.","DOI":"10.1080\/09513590.2021.1871892"},{"key":"ref_8","first-page":"419","article-title":"Quantitative Assessment of Nutrition in Patients with Polycystic Ovary Syndrome (PCOS)","volume":"67","author":"Szczuko","year":"2016","journal-title":"Rocz. Panstw. Zakl. Hig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"139239","DOI":"10.1155\/2013\/139239","article-title":"Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines","volume":"2013","author":"Makki","year":"2013","journal-title":"ISRN Inflamm."},{"key":"ref_10","first-page":"14","article-title":"Zesp\u00f3\u0142 Policystycznych Jajnik\u00f3w Jako Przyczyna Niep\u0142odno\u015bci Kobiecej [Polycystic Ovary Syndrome as a Cause of Female Infertility]","volume":"17","year":"2012","journal-title":"Po\u0142o\u017cna Nauka I Prakt."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"110987","DOI":"10.1016\/j.nut.2020.110987","article-title":"Association between Empirically Derived Dietary Patterns and Polycystic Ovary Syndrome: A Case-Control Study","volume":"79\u201380","author":"Panjeshahin","year":"2020","journal-title":"Nutrition"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Szczuko, M., Zapalowska-Chwy\u0107, M., and Drozd, R. (2019). A Low Glycemic Index Decreases Inflammation by Increasing the Concentration of Uric Acid and the Activity of Glutathione Peroxidase (GPx3) in Patients with Polycystic Ovary Syndrome (PCOS). Molecules, 24.","DOI":"10.3390\/molecules24081508"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/JOE-16-0598","article-title":"Skeletal Muscle Insulin Resistance: Role of Mitochondria and Other ROS Sources","volume":"233","author":"Iossa","year":"2017","journal-title":"J. Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Barber, T.M., Kyrou, I., Randeva, H.S., and Weickert, M.O. (2021). Mechanisms of Insulin Resistance at the Crossroad of Obesity with Associated Metabolic Abnormalities and Cognitive Dysfunction. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020546"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kempegowda, P., Melson, E., Manolopoulos, K.N., Arlt, W., and O\u2019Reilly, M.W. (2020). Implicating Androgen Excess in Propagating Metabolic Disease in Polycystic Ovary Syndrome. Adv. Endocrinol. Metab., 11.","DOI":"10.1177\/2042018820934319"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1067\/mob.2002.126650","article-title":"Polycystic Ovarian Syndrome and Insulin Resistance in White and Mexican American Women: A Comparison of Two Distinct Populations","volume":"187","author":"Kauffman","year":"2002","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1053\/j.gastro.2007.03.059","article-title":"Obesity, Inflammation, and Insulin Resistance","volume":"132","author":"Shoelson","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Fajstova, A., Galanova, N., Coufal, S., Malkova, J., Kostovcik, M., Cermakova, M., Pelantova, H., Kuzma, M., Sediva, B., and Hudcovic, T. (2020). Diet Rich in Simple Sugars Promotes Pro-Inflammatory Response via Gut Microbiota Alteration and TLR4 Signaling. Cells, 9.","DOI":"10.3390\/cells9122701"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1210\/jc.2019-00987","article-title":"Oxidative Stress in Response to Saturated Fat Ingestion Is Linked to Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome","volume":"104","author":"Considine","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jsbmb.2015.09.003","article-title":"Increased Androgen Levels in Rats Impair Glucose-Stimulated Insulin Secretion through Disruption of Pancreatic Beta Cell Mitochondrial Function","volume":"154","author":"Wang","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Liu, S., Navarro, G., and Mauvais-Jarvis, F. (2010). Androgen Excess Produces Systemic Oxidative Stress and Predisposes to Beta-Cell Failure in Female Mice. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0011302"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1124\/pr.110.002980","article-title":"NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair","volume":"63","author":"Jiang","year":"2011","journal-title":"Pharm. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2001-0039","article-title":"Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes","volume":"23","author":"Evans","year":"2002","journal-title":"Endocr. Rev."},{"key":"ref_25","first-page":"934","article-title":"Saturated Fat Ingestion Promotes Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Polycystic Ovary Syndrome","volume":"104","author":"Considine","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mehy.2016.09.016","article-title":"High Glycemic Index Diet in PCOS Patients. The Analysis of IGF I and TNF-\u03b1 Pathways in Metabolic Disorders","volume":"96","author":"Szczuko","year":"2016","journal-title":"Med. Hypotheses"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e8592348","DOI":"10.1155\/2019\/8592348","article-title":"Potential Applications of NRF2 Inhibitors in Cancer Therapy","volume":"2019","author":"Panieri","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Panieri, E., Buha, A., Telkoparan-Akillilar, P., Cevik, D., Kouretas, D., Veskoukis, A., Skaperda, Z., Tsatsakis, A., Wallace, D., and Suzen, S. (2020). Potential Applications of NRF2 Modulators in Cancer Therapy. Antioxidants, 9.","DOI":"10.3390\/antiox9030193"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Panieri, E., Telkoparan-Akillilar, P., Suzen, S., and Saso, L. (2020). The NRF2\/KEAP1 Axis in the Regulation of Tumor Metabolism: Mechanisms and Therapeutic Perspectives. Biomolecules, 10.","DOI":"10.3390\/biom10050791"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"16817","DOI":"10.1074\/jbc.R117.800169","article-title":"Stress-Sensing Mechanisms and the Physiological Roles of the Keap1-Nrf2 System during Cellular Stress","volume":"292","author":"Suzuki","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3765","DOI":"10.1038\/onc.2012.388","article-title":"Nrf2 Is Controlled by Two Distinct \u03b2-TrCP Recognition Motifs in Its Neh6 Domain, One of Which Can Be Modulated by GSK-3 Activity","volume":"32","author":"Chowdhry","year":"2013","journal-title":"Oncogene"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1101\/gad.238246.114","article-title":"Hrd1 Suppresses Nrf2-Mediated Cellular Protection during Liver Cirrhosis","volume":"28","author":"Wu","year":"2014","journal-title":"Genes Dev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1089\/ars.2014.5843","article-title":"The PTEN\/NRF2 Axis Promotes Human Carcinogenesis","volume":"21","author":"Rojo","year":"2014","journal-title":"Antioxid. Redox. Signal."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"73593","DOI":"10.18632\/oncotarget.12435","article-title":"NRF2 Promotes Breast Cancer Cell Proliferation and Metastasis by Increasing RhoA\/ROCK Pathway Signal Transduction","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1002\/mc.22615","article-title":"ABCF2, an Nrf2 Target Gene, Contributes to Cisplatin Resistance in Ovarian Cancer Cells","volume":"56","author":"Bao","year":"2017","journal-title":"Mol. Carcinog."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1097\/IGC.0b013e31822d0eb2","article-title":"Association of Keap1 and Nrf2 Genetic Mutations and Polymorphisms with Endometrioid Endometrial Adenocarcinoma Survival","volume":"21","author":"Wong","year":"2011","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1053\/j.gastro.2008.06.082","article-title":"Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer","volume":"135","author":"Shibata","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.bbrc.2007.08.051","article-title":"A Mutation of Keap1 Found in Breast Cancer Impairs Its Ability to Repress Nrf2 Activity","volume":"362","author":"Nioi","year":"2007","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.1133427","article-title":"The Consensus Coding Sequences of Human Breast and Colorectal Cancers","volume":"314","author":"Jones","year":"2006","journal-title":"Science"},{"key":"ref_40","first-page":"4458","article-title":"KEAP1\/NRF2 Signaling Pathway Mutations in Cervical Cancer","volume":"22","author":"Chu","year":"2018","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1158\/0008-5472.CAN-10-4668","article-title":"Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer","volume":"71","author":"Konstantinopoulos","year":"2011","journal-title":"Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Martinez, V.D., Vucic, E.A., Thu, K.L., Hubaux, R., Enfield, K.S.S., Pikor, L.A., Becker-Santos, D.D., Brown, C.J., Lam, S., and Lam, W.L. (2015). Unique Somatic and Malignant Expression Patterns Implicate PIWI-Interacting RNAs in Cancer-Type Specific Biology. Sci Rep., 5.","DOI":"10.1038\/srep10423"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1158\/1541-7786.MCR-13-0246-T","article-title":"The Impact of MiRNA-Based Molecular Diagnostics and Treatment of NRF2-Stabilized Tumors","volume":"12","author":"Yamamoto","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1152\/physiolgenomics.00114.2017","article-title":"Gut Microbiome May Contribute to Insulin Resistance and Systemic Inflammation in Obese Rodents: A Meta-Analysis","volume":"50","author":"Jiao","year":"2018","journal-title":"Physiol Genom."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Bai, L., Guan, M., Zhou, X., Liang, X., Lv, Y., Yi, H., Zhou, H., Liu, T., and Gong, P. (2021). Potential probiotics Lactobacillus casei K11 combined with plant extracts reduce markers of type 2 diabetes mellitus in mice. J. Appl. Microbiol.","DOI":"10.1111\/jam.15061"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Bamberger, C., Rossmeier, A., Lechner, K., Wu, L., Waldmann, E., Fischer, S., Stark, R.G., Altenhofer, J., Henze, K., and Parhofer, K.G. (2018). A Walnut-Enriched Diet Affects Gut Microbiome in Healthy Caucasian Subjects: A Randomized, Controlled Trial. Nutrients, 10.","DOI":"10.3390\/nu10020244"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2017.1406584","article-title":"Low Dietary Fiber Intake Increases Collinsella Abundance in the Gut Microbiota of Overweight and Obese Pregnant Women","volume":"9","author":"Barrett","year":"2018","journal-title":"Gut Microbes"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ojo, O., Feng, Q.-Q., Ojo, O.O., and Wang, X.-H. (2020). The Role of Dietary Fibre in Modulating Gut Microbiota Dysbiosis in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Nutrients, 12.","DOI":"10.3390\/IECN2020-06986"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1194\/jlr.R036012","article-title":"The Role of Short-Chain Fatty Acids in the Interplay between Diet, Gut Microbiota, and Host Energy Metabolism","volume":"54","author":"Groen","year":"2013","journal-title":"J. Lipid Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/21623945.2016.1252011","article-title":"Branched Short-Chain Fatty Acids Modulate Glucose and Lipid Metabolism in Primary Adipocytes","volume":"5","author":"Heimann","year":"2016","journal-title":"Adipocyte"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Matija\u0161i\u0107, M., Me\u0161trovi\u0107, T., Peri\u0107, M., \u010cip\u010di\u0107 Paljetak, H., Panek, M., Vrane\u0161i\u0107 Bender, D., Ljubas Kele\u010di\u0107, D., Krznari\u0107, \u017d., and Verbanac, D. (2016). Modulating Composition and Metabolic Activity of the Gut Microbiota in IBD Patients. Int. J. Mol. Sci, 17.","DOI":"10.3390\/ijms17040578"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Me\u0161trovi\u0107, T., Matija\u0161i\u0107, M., Peri\u0107, M., \u010cip\u010di\u0107 Paljetak, H., Bare\u0161i\u0107, A., and Verbanac, D. (2020). The Role of Gut, Vaginal, and Urinary Microbiome in Urinary Tract Infections: From Bench to Bedside. Diagnostics, 11.","DOI":"10.3390\/diagnostics11010007"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0960-0760(91)90033-2","article-title":"The Role of Nutrition and Insulin in the Regulation of Sex Hormone Binding Globulin","volume":"39","author":"Franks","year":"1991","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1207\/S15327914NC382_3","article-title":"Changes in Sex Hormone-Binding Globulin, Insulin, and Serum Lipids in Postmenopausal Women on a Low-Fat, High-Fiber Diet Combined with Exercise","volume":"38","author":"Tymchuk","year":"2000","journal-title":"Nutr. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1002\/cncr.11735","article-title":"The Effects of a Low-Fat\/High-Fiber Diet on Sex Hormone Levels and Menstrual Cycling in Premenopausal Women: A 12-Month Randomized Trial (the Diet and Hormone Study)","volume":"98","author":"Gann","year":"2003","journal-title":"Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1210\/jc.2002-020815","article-title":"Dietary Composition in Restoring Reproductive and Metabolic Physiology in Overweight Women with Polycystic Ovary Syndrome","volume":"88","author":"Moran","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"295","DOI":"10.5603\/GP.a2018.0051","article-title":"Changes in the IGF-1 and TNF-\u03b1 Synthesis Pathways before and after Three-Month Reduction Diet with Low Glicemic Index in Women with PCOS","volume":"89","author":"Szczuko","year":"2018","journal-title":"Ginekol. Pol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/advances\/nmaa092","article-title":"Effects of Dietary Glycemic Index and Glycemic Load on Cardiometabolic and Reproductive Profiles in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"12","author":"Kazemi","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fendo.2020.00284","article-title":"Dietary \u03b1-Linolenic Acid-Rich Flaxseed Oil Exerts Beneficial Effects on Polycystic Ovary Syndrome Through Sex Steroid Hormones-Microbiota-Inflammation Axis in Rats","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Barber, T.M., Kabisch, S., Pfeiffer, A.F.H., and Weickert, M.O. (2020). The Health Benefits of Dietary Fibre. Nutrients, 12.","DOI":"10.3390\/nu12103209"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Hoover, S.E., Gower, B.A., Cedillo, Y.E., Chandler-Laney, P.C., Deemer, S.E., and Goss, A.M. (2021). Changes in Ghrelin and Glucagon Following a Low Glycemic Load Diet in Women with PCOS. J. Clin. Endocrinol. Metab.","DOI":"10.1210\/clinem\/dgab028"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e05890","DOI":"10.1016\/j.heliyon.2020.e05890","article-title":"High Fructose-Enriched Diet Synergistically Exacerbates Endocrine but Not Metabolic Changes in Letrozole-Induced Polycystic Ovarian Syndrome in Wistar Rats","volume":"7","author":"Akintayo","year":"2021","journal-title":"Heliyon"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Shang, Y., Zhou, H., Hu, M., and Feng, H. (2020). Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome. J. Clin. Endocrinol. Metab., 105.","DOI":"10.1210\/clinem\/dgaa425"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejogrb.2020.03.010","article-title":"Diets with Lower Carbohydrate Concentrations Improve Insulin Sensitivity in Women with Polycystic Ovary Syndrome: A Meta-Analysis","volume":"248","author":"Porchia","year":"2020","journal-title":"Eur. J. Obs. Gynecol. Reprod. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Shishehgar, F., Mirmiran, P., Rahmati, M., Tohidi, M., and Ramezani Tehrani, F. (2019). Does a Restricted Energy Low Glycemic Index Diet Have a Different Effect on Overweight Women with or without Polycystic Ovary Syndrome?. BMC Endocr. Disord., 19.","DOI":"10.1186\/s12902-019-0420-1"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12967-020-02277-0","article-title":"Effects of a Ketogenic Diet in Overweight Women with Polycystic Ovary Syndrome","volume":"18","author":"Paoli","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4038\/cmj.v64i3.8958","article-title":"Association between Visceral Adiposity Index, Hirsutism and Cardiometabolic Risk Factors in Women with Polycystic Ovarian Syndrome: A Cross-Sectional Study","volume":"64","author":"Fonseka","year":"2019","journal-title":"Ceylon Med. J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ypmed.2016.10.020","article-title":"Effects of Aerobic, Resistance, and Combined Exercise Training on Insulin Resistance Markers in Overweight or Obese Children and Adolescents: A Systematic Review and Meta-Analysis","volume":"93","author":"Marson","year":"2016","journal-title":"Prev. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3389\/fphys.2020.00606","article-title":"Exercise Interventions in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"11","author":"Patten","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Santos, I.K.D., Nunes, F.A.S.d.S., Queiros, V.S., Cobucci, R.N., Dantas, P.B., Soares, G.M., Cabral, B.G.d.A.T., Maranh\u00e3o, T.M.d.O., and Dantas, P.M.S. (2021). Effect of High-Intensity Interval Training on Metabolic Parameters in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0245023"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Shele, G., Genkil, J., and Speelman, D. (2020). A Systematic Review of the Effects of Exercise on Hormones in Women with Polycystic Ovary Syndrome. J. Funct. Morphol. Kinesiol., 5.","DOI":"10.3390\/jfmk5020035"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jad.2020.12.084","article-title":"The Mental Health of Chinese Women with Polycystic Ovary Syndrome Is Related to Sleep Disorders, Not Disease Status","volume":"282","author":"Yang","year":"2021","journal-title":"J. Affect. Disord."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000262524","article-title":"Role of Sleep and Sleep Loss in Hormonal Release and Metabolism","volume":"17","author":"Leproult","year":"2010","journal-title":"Endocr. Dev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/B978-0-444-59602-4.00007-1","article-title":"Sleep Characteristics and Insulin Sensitivity in Humans","volume":"124","author":"Donga","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.metabol.2018.02.010","article-title":"Sleep Influences on Obesity, Insulin Resistance, and Risk of Type 2 Diabetes","volume":"84","author":"Reutrakul","year":"2018","journal-title":"Metabolism"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"35405","DOI":"10.1038\/srep35405","article-title":"Chronic Sleep Disruption Alters Gut Microbiota, Induces Systemic and Adipose Tissue Inflammation and Insulin Resistance in Mice","volume":"6","author":"Poroyko","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_77","first-page":"865","article-title":"The Role of Melatonin in Polycystic Ovary Syndrome: A Review","volume":"17","author":"Mojaverrostami","year":"2019","journal-title":"Int. J. Reprod. Biomed."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"105570","DOI":"10.1016\/j.jsbmb.2019.105570","article-title":"The Implications of Vitamin Content in the Plasma in Reference to the Parameters of Carbohydrate Metabolism and Hormone and Lipid Profiles in PCOS","volume":"198","author":"Szczuko","year":"2020","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Szczuko, M., Szyd\u0142owska, I., and Nawrocka-Rutkowska, J. (2021). A Properly Balanced Reduction Diet and\/or Supplementation Solve the Problem with the Deficiency of These Vitamins Soluble in Water in Patients with PCOS. Nutrients, 13.","DOI":"10.3390\/nu13030746"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"212","DOI":"10.2174\/1871530315666150316122128","article-title":"Vitamin-Mediated Immune Regulation in the Development of Inflammatory Diseases","volume":"15","author":"Suzuki","year":"2015","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Wanders, D., Graff, E.C., White, B.D., and Judd, R.L. (2013). Niacin Increases Adiponectin and Decreases Adipose Tissue Inflammation in High Fat Diet-Fed Mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0071285"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/jhrs.JHRS_74_16","article-title":"The Effect of Metformin Treatment on the Serum Levels of Homocysteine, Folic Acid, and Vitamin B12 in Patients with Polycystic Ovary Syndrome","volume":"10","author":"Esmaeilzadeh","year":"2017","journal-title":"J. Hum. Reprod. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.pcad.2018.01.009","article-title":"Thiamine and Cardiovascular Disease: A Literature Review","volume":"61","author":"DiNicolantonio","year":"2018","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.numecd.2018.06.013","article-title":"Thiamine Deficiency and Cardiovascular Disorders","volume":"28","author":"Eshak","year":"2018","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/09513590.2020.1779689","article-title":"The Effect of Coenzyme Q10 Supplementation on Inflammatory and Endothelial Dysfunction Markers in Overweight\/Obese Polycystic Ovary Syndrome Patients","volume":"37","author":"Taghizadeh","year":"2021","journal-title":"Gynecol. Endocrinol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1017\/S0954422409389301","article-title":"Vitamin D: Emerging New Roles in Insulin Sensitivity","volume":"22","author":"Teegarden","year":"2009","journal-title":"Nutr. Res. Rev."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.3390\/nu7064555","article-title":"Serum Vitamin D Levels and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"7","author":"He","year":"2015","journal-title":"Nutrients"},{"key":"ref_88","first-page":"757","article-title":"Effect of Vitamin D3 Treatment on Glucose Metabolism and Menstrual Frequency in Polycystic Ovary Syndrome Women: A Pilot Study","volume":"34","author":"Wehr","year":"2011","journal-title":"J. Endocrinol. Investig."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12011-017-1085-0","article-title":"Magnesium-Zinc-Calcium-Vitamin D Co-Supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"182","author":"Maktabi","year":"2018","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jad.2018.05.027","article-title":"The Influences of Vitamin D and Omega-3 Co-Supplementation on Clinical, Metabolic and Genetic Parameters in Women with Polycystic Ovary Syndrome","volume":"238","author":"Jamilian","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_91","first-page":"321","article-title":"Myo-Inositol vs. D-Chiro Inositol in PCOS Treatment","volume":"67","author":"Formuso","year":"2015","journal-title":"Minerva Ginecol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/09513590.2016.1236078","article-title":"Comparison of Two Insulin Sensitizers, Metformin and Myo-Inositol, in Women with Polycystic Ovary Syndrome (PCOS)","volume":"33","author":"Fruzzetti","year":"2017","journal-title":"Gynecol. Endocrinol."},{"key":"ref_93","first-page":"e1844","article-title":"New Therapeutic Approaches in Obesity and Metabolic Syndrome Associated with Polycystic Ovary Syndrome","volume":"9","author":"Saleem","year":"2017","journal-title":"Cureus"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/jog.12319","article-title":"Myo-Inositol Modulates Insulin and Luteinizing Hormone Secretion in Normal Weight Patients with Polycystic Ovary Syndrome","volume":"40","author":"Genazzani","year":"2014","journal-title":"J. Obs. Gynaecol. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ejogrb.2015.09.024","article-title":"Results from the International Consensus Conference on Myo-Inositol and d-Chiro-Inositol in Obstetrics and Gynecology: The Link between Metabolic Syndrome and PCOS","volume":"195","author":"Facchinetti","year":"2015","journal-title":"Eur. J. Obs. Gynecol. Reprod. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1849162","DOI":"10.1155\/2016\/1849162","article-title":"Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials","volume":"2016","author":"Unfer","year":"2016","journal-title":"Int. J. Endocrinol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/1745-6215-14-226","article-title":"Effect of Berberine on Insulin Resistance in Women with Polycystic Ovary Syndrome: Study Protocol for a Randomized Multicenter Controlled Trial","volume":"14","author":"Li","year":"2013","journal-title":"Trials"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00404-020-05450-4","article-title":"Polycystic Ovary Syndrome Management: A Review of the Possible Amazing Role of Berberine","volume":"301","author":"Rondanelli","year":"2020","journal-title":"Arch. Gynecol. Obs."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Xiang, D., Lu, J., Wei, C., Cai, X., Wang, Y., Liang, Y., Xu, M., Wang, Z., Liu, M., and Wang, M. (2020). Berberine Ameliorates Prenatal Dihydrotestosterone Exposure-Induced Autism-Like Behavior by Suppression of Androgen Receptor. Front. Cell Neurosci., 14.","DOI":"10.3389\/fncel.2020.00087"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/jmf.2019.0088","article-title":"Berberine and Dyslipidemia: Different Applications and Biopharmaceutical Formulations Without Statin-Like Molecules-A Meta-Analysis","volume":"23","author":"Bertuccioli","year":"2020","journal-title":"J. Med. Food"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1530\/EJE-11-0616","article-title":"A Clinical Study on the Short-Term Effect of Berberine in Comparison to Metformin on the Metabolic Characteristics of Women with Polycystic Ovary Syndrome","volume":"166","author":"Wei","year":"2012","journal-title":"Eur. J. Endocrinol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Kuang, H., Duan, Y., Li, D., Xu, Y., Ai, W., Li, W., Wang, Y., Liu, S., Li, M., and Liu, X. (2020). The Role of Serum Inflammatory Cytokines and Berberine in the Insulin Signaling Pathway among Women with Polycystic Ovary Syndrome. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0235404"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.fertnstert.2005.06.028","article-title":"Effect of Chromium Supplementation on Insulin Resistance and Ovarian and Menstrual Cyclicity in Women with Polycystic Ovary Syndrome","volume":"84","author":"Lucidi","year":"2005","journal-title":"Fertil. Steril."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/jog.13462","article-title":"Chromium Supplementation in Women with Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis","volume":"44","author":"Tang","year":"2018","journal-title":"J. Obs. Gynaecol. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jtemb.2017.04.008","article-title":"Chromium Supplementation and Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis","volume":"42","author":"Fazelian","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/jog.12907","article-title":"Chromium Picolinate Reduces Insulin Resistance in Polycystic Ovary Syndrome: Randomized Controlled Trial","volume":"42","author":"Ashoush","year":"2016","journal-title":"J. Obs. Gynaecol. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12011-019-1654-5","article-title":"The Possibilities of Using Chromium Salts as an Agent Supporting Treatment of Polycystic Ovary Syndrome","volume":"192","author":"Piotrowska","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Maxel, T., Svendsen, P.F., Smidt, K., Lauridsen, J.K., Brock, B., Pedersen, S.B., Rungby, J., and Larsen, A. (2017). Expression Patterns and Correlations with Metabolic Markers of Zinc Transporters ZIP14 and ZNT1 in Obesity and Polycystic Ovary Syndrome. Front. Endocrinol., 8.","DOI":"10.3389\/fendo.2017.00038"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Nasiadek, M., Stragierowicz, J., Klimczak, M., and Kilanowicz, A. (2020). The Role of Zinc in Selected Female Reproductive System Disorders. Nutrients, 12.","DOI":"10.3390\/nu12082464"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s12011-014-9941-7","article-title":"Zinc and Homocysteine Levels in Polycystic Ovarian Syndrome Patients with Insulin Resistance","volume":"158","author":"Guler","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ejogrb.2013.01.021","article-title":"Plasma Selenium Levels in Turkish Women with Polycystic Ovary Syndrome","volume":"168","author":"Coskun","year":"2013","journal-title":"Eur. J. Obs. Gynecol. Reprod. Biol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Michael, P.J., Stepani\u0107, V., Nadja, T., Panek, M., and Verbanac, D. (2019). Mild Plant and Dietary Immunomodulators. Nijkamp Parnham\u2019s Princ. Immunopharmacol., 561\u2013587.","DOI":"10.1007\/978-3-030-10811-3_28"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"7397","DOI":"10.1039\/C9FO01730E","article-title":"Roles of Different N-3\/n-6 PUFA Ratios in Ovarian Cell Development and Steroidogenesis in PCOS Rats","volume":"10","author":"Ma","year":"2019","journal-title":"Food. Funct."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Popova, A., and Mihaylova, D. (2018). A Review of the Medicinal Plants in Bulgaria: Collection, Storage, And Extraction Techniques. Asian J. Pharm. Clin. Res., 28\u201335.","DOI":"10.22159\/ajpcr.2018.v11i3.22994"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1515\/bmc-2020-0005","article-title":"The Role of Medicinal Herbs in Treatment of Insulin Resistance in Patients with Polycystic Ovary Syndrome: A Literature Review","volume":"11","author":"Ashkar","year":"2020","journal-title":"Biomol. Concepts"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4103\/jehp.jehp_67_15","article-title":"Effect of Green Tea on Metabolic and Hormonal Aspect of Polycystic Ovarian Syndrome in Overweight and Obese Women Suffering from Polycystic Ovarian Syndrome: A Clinical Trial","volume":"6","author":"Tehrani","year":"2017","journal-title":"J. Educ. Health Promot."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/jhn.12290","article-title":"The Effect of Marjoram (Origanum Majorana) Tea on the Hormonal Profile of Women with Polycystic Ovary Syndrome: A Randomised Controlled Pilot Study","volume":"29","author":"Tukan","year":"2016","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"118353","DOI":"10.1016\/j.lfs.2020.118353","article-title":"The Ameliorative Effects of Marjoram in Dehydroepiandrosterone Induced Polycystic Ovary Syndrome in Rats","volume":"261","author":"Matani","year":"2020","journal-title":"Life Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/ptr.2900","article-title":"Spearmint Herbal Tea Has Significant Anti-Androgen Effects in Polycystic Ovarian Syndrome. A Randomized Controlled Trial","volume":"24","author":"Grant","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"651","DOI":"10.15171\/apb.2017.078","article-title":"Role of Essential Oil of Mentha Spicata (Spearmint) in Addressing Reverse Hormonal and Folliculogenesis Disturbances in a Polycystic Ovarian Syndrome in a Rat Model","volume":"7","author":"Alaee","year":"2017","journal-title":"Adv. Pharm. Bull."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"484","DOI":"10.3389\/fendo.2019.00484","article-title":"Licorice: From Pseudohyperaldosteronism to Therapeutic Uses","volume":"10","author":"Sabbadin","year":"2019","journal-title":"Front. Endocrinol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Arentz, S., Abbott, J.A., Smith, C.A., and Bensoussan, A. (2014). Herbal Medicine for the Management of Polycystic Ovary Syndrome (PCOS) and Associated Oligo\/Amenorrhoea and Hyperandrogenism; a Review of the Laboratory Evidence for Effects with Corroborative Clinical Findings. BMC Complement. Altern Med., 14.","DOI":"10.1186\/1472-6882-14-511"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11906-019-1007-y","article-title":"Food Products That May Cause an Increase in Blood Pressure","volume":"22","author":"Adamczak","year":"2020","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/jocd.12930","article-title":"An Overview of Herbal Alternatives in Androgenetic Alopecia","volume":"18","author":"Dhariwala","year":"2019","journal-title":"J. Cosmet Derm."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jtcme.2018.03.001","article-title":"Effect of Vitex Negundo L. Seeds in Letrozole Induced Polycystic Ovarian Syndrome","volume":"9","author":"Kakadia","year":"2019","journal-title":"J. Tradit Complement. Med."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13048-020-00633-8","article-title":"A Combination of Spearmint and Flaxseed Extract Improved Endocrine and Histomorphology of Ovary in Experimental PCOS","volume":"13","author":"Mehraban","year":"2020","journal-title":"J. Ovarian Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jsbmb.2005.02.002","article-title":"Mammalian Lignans and Genistein Decrease the Activities of Aromatase and 17beta-Hydroxysteroid Dehydrogenase in MCF-7 Cells","volume":"94","author":"Brooks","year":"2005","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"153395","DOI":"10.1016\/j.phymed.2020.153395","article-title":"Effects of Curcumin Supplementation on Blood Glucose, Insulin Resistance and Androgens in Patients with Polycystic Ovary Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial","volume":"80","author":"Heshmati","year":"2021","journal-title":"Phytomedicine"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Marmitt, D.J., Shahrajabian, M.H., Goettert, M.I., and Rempel, C. (2021). Clinical Trials with Plants in Diabetes Mellitus Therapy: A Systematic Review. Expert Rev. Clin. Pharm., 1\u201313.","DOI":"10.1080\/17512433.2021.1917380"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.dsx.2020.01.002","article-title":"The Effects of Curcumin Supplementation on Oxidative Stress, Sirtuin-1 and Peroxisome Proliferator Activated Receptor \u03b3 Coactivator 1\u03b1 Gene Expression in Polycystic Ovarian Syndrome (PCOS) Patients: A Randomized Placebo-Controlled Clinical Trial","volume":"14","author":"Heshmati","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"643119","DOI":"10.3389\/fphar.2021.643119","article-title":"Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review","volume":"12","author":"Yuandani","year":"2021","journal-title":"Front. Pharm."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"6298","DOI":"10.1002\/jcp.27360","article-title":"Curcumin Attenuates Proangiogenic and Proinflammatory Factors in Human Eutopic Endometrial Stromal Cells through the NF-\u039aB Signaling Pathway","volume":"234","author":"Chowdhury","year":"2019","journal-title":"J. Cell Physiol"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1590\/S1678-77572010000400015","article-title":"Effects of Folk Medicinal Plant Extract Ankaferd Blood Stopper\u00ae on Early Bone Healing","volume":"18","author":"Demircan","year":"2010","journal-title":"J. Appl. Oral Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/ptr.6535","article-title":"The Effect of Nettle (Urtica Dioica) Supplementation on the Glycemic Control of Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis","volume":"34","author":"Ziaei","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2174\/2210290601203010038","article-title":"Antioxidant, Hepatoprotective, and Anthelmintic Activities of Methanol Extract of Urtica Dioica L. Leaves","volume":"3","author":"Murugamani","year":"2012","journal-title":"Pharm. Crop."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Ferro, D., Baratta, F., Pastori, D., Cocomello, N., Colantoni, A., Angelico, F., and Del Ben, M. (2020). New Insights into the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Gut-Derived Lipopolysaccharides and Oxidative Stress. Nutrients, 12.","DOI":"10.3390\/nu12092762"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.phymed.2018.03.028","article-title":"An in Vitro and in Vivo Study of a 4-Herb Formula on the Management of Diet-Induced Metabolic Syndrome","volume":"42","author":"Wat","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_138","first-page":"100255","article-title":"Silymarin Is an Ally against Insulin Resistance: A Review","volume":"23","year":"2020","journal-title":"Ann. Hepatol."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Oppedisano, F., Muscoli, C., Musolino, V., Carresi, C., Macr\u00ec, R., Giancotta, C., Bosco, F., Maiuolo, J., Scarano, F., and Paone, S. (2020). The Protective Effect of Cynara Cardunculus Extract in Diet-Induced NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily. Nutrients, 12.","DOI":"10.20944\/preprints202004.0109.v1"},{"key":"ref_140","first-page":"3481","article-title":"[Study on literature of artichoke and properties of traditional Chinese medicine]","volume":"45","author":"Zhao","year":"2020","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1177\/1535370218789068","article-title":"Mulberry and Dandelion Water Extracts Prevent Alcohol-Induced Steatosis with Alleviating Gut Microbiome Dysbiosis","volume":"243","author":"Park","year":"2018","journal-title":"Exp. Biol. Med."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"72","DOI":"10.7762\/cnr.2021.10.1.72","article-title":"The Effects of Nigella Sativa Supplementation on Liver Enzymes Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"10","author":"Azizi","year":"2021","journal-title":"Clin. Nutr. Res."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/7\/2452\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:31:26Z","timestamp":1760164286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/7\/2452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,18]]},"references-count":142,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["nu13072452"],"URL":"https:\/\/doi.org\/10.3390\/nu13072452","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,18]]}}}