{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:43:00Z","timestamp":1778517780798,"version":"3.51.4"},"reference-count":39,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iron deficiency with or without anemia, needing continuous iron supplementation, is very common in obese patients, particularly those requiring bariatric surgery. The aim of this study was to address the impact of weight loss on the rescue of iron balance in patients who underwent sleeve gastrectomy (SG), a procedure that preserves the duodenum, the main site of iron absorption. The cohort included 88 obese women; sampling of blood and duodenal biopsies of 35 patients were performed before and one year after SG. An analysis of the 35 patients consisted in evaluating iron homeostasis including hepcidin, markers of erythroid iron deficiency (soluble transferrin receptor (sTfR) and erythrocyte protoporphyrin (PPIX)), expression of duodenal iron transporters (DMT1 and ferroportin) and inflammatory markers. After surgery, sTfR and PPIX were decreased. Serum hepcidin levels were increased despite the significant reduction in inflammation. DMT1 abundance was negatively correlated with higher level of serum hepcidin. Ferroportin abundance was not modified. This study shed a new light in effective iron recovery pathways after SG involving suppression of inflammation, improvement of iron absorption, iron supply and efficiency of erythropoiesis, and finally beneficial control of iron homeostasis by hepcidin. Thus, recommendations for iron supplementation of patients after SG should take into account these new parameters of iron status assessment.<\/jats:p>","DOI":"10.3390\/nu13082516","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T10:31:44Z","timestamp":1627036304000},"page":"2516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hepcidin and Iron Deficiency in Women One Year after Sleeve Gastrectomy: A Prospective Cohort Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1398-6473","authenticated-orcid":false,"given":"Thibaud","family":"Lefebvre","sequence":"first","affiliation":[{"name":"Centre de Recherche sur l\u2018Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, France"},{"name":"Centre Fran\u00e7ais des Porphyries, H\u00f4pital Louis Mourier, Colombes, APHP, Nord-Universit\u00e9 de Paris, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Coupaye","sequence":"additional","affiliation":[{"name":"Centre de Recherche sur l\u2018Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, France"},{"name":"Service des Explorations Fonctionnelles, Centre Int\u00e9gr\u00e9 Nord Francilien de l\u2019Ob\u00e9sit\u00e9 (CINFO), H\u00f4pital Louis Mourier, Colombes, APHP.Nord-Universit\u00e9 de Paris, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Esposito-Far\u00e8se","sequence":"additional","affiliation":[{"name":"INSERM CIC-EC 1425, H\u00f4pital Bichat, 75018 Paris, France"},{"name":"APHP, D\u00e9partement Epid\u00e9miologie, Biostatistiques Recherche Clinique, H\u00f4pital Bichat, 75018 Paris, France"},{"name":"Unit\u00e9 de Recherche Clinique, H\u00f4pital Bichat, AP-HP, Nord-Universit\u00e9 de Paris, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-9760","authenticated-orcid":false,"given":"Nathalie","family":"Gault","sequence":"additional","affiliation":[{"name":"INSERM CIC-EC 1425, H\u00f4pital Bichat, 75018 Paris, France"},{"name":"APHP, D\u00e9partement Epid\u00e9miologie, Biostatistiques Recherche Clinique, H\u00f4pital Bichat, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neila","family":"Talbi","sequence":"additional","affiliation":[{"name":"Centre de Recherche sur l\u2018Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, France"},{"name":"Centre Fran\u00e7ais des Porphyries, H\u00f4pital Louis Mourier, Colombes, APHP, Nord-Universit\u00e9 de Paris, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Quintin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique, H\u00f4pital Bichat, AP-HP, Nord-Universit\u00e9 de Paris, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Centre de Recherche sur l\u2018Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, France"},{"name":"Centre Fran\u00e7ais des Porphyries, H\u00f4pital Louis Mourier, Colombes, APHP, Nord-Universit\u00e9 de Paris, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumeya","family":"Bekri","sequence":"additional","affiliation":[{"name":"Department of Metabolic Biochemistry, Rouen University Hospital, 76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Bado","sequence":"additional","affiliation":[{"name":"Centre de Recherche sur l\u2018Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, 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Personalized Medicine, Normandie University, 76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-5592","authenticated-orcid":false,"given":"Zoubida","family":"Karim","sequence":"additional","affiliation":[{"name":"Centre de Recherche sur l\u2018Inflammation, Universite de Paris, INSERM, CNRS, 75018 Paris, France"},{"name":"Universite de Toulouse INSERM, CNRS, Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"ref_1","unstructured":"(2021, July 14). 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