{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:08:45Z","timestamp":1773248925487,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: There is a handful of controversial data from observational studies on the serum levels of mannose and risks of coronary artery disease (CAD) and other cardiometabolic risk factors. We applied Mendelian Randomization (MR) analysis to obtain estimates of the causal effect of serum mannose on the risk of CAD and on cardiometabolic risk factors. Methods: Two-sample MR was implemented by using summary-level data from the largest genome-wide association studies (GWAS) conducted on serum mannose and CAD and cardiometabolic risk factors. The inverse variance weighted method (IVW) was used to estimate the effects, and a sensitivity analysis including the weighted median (WM)-based method, MR-Egger, MR-Pleiotropy RESidual Sum and Outlier (PRESSO) were applied. Radial MR Methods was applied to remove outliers subject to pleiotropic bias. We further conducted a leave-one-out analysis. Results: Mannose had no significant effect on CAD (IVW: odds ratio: 0.96 (95% Confidence Interval (95%CI): 0.71\u22121.30)), total cholesterol (TC) (IVW: 95%CI: 0.60\u22121.08), low density lipoprotein (LDL) (IVW: 95%CI = 0.68\u22121.15), high density lipoprotein (HDL) (IVW: 95%CI = 0.85\u22121.20), triglycerides (TG) (IVW: 95%CI = 0.38\u22121.08), waist circumference (WC) (IVW: 95%CI = 0.94\u22121.37), body mass index (BMI) (IVW: 95%CI = 0.93\u22121.29) and fasting blood glucose (FBG) (IVW: 95%CI = 0.92\u22121.33), with no heterogeneity for CAD, HDL, WC and BMI (all p &gt; 0.092), while a significant heterogeneity was observed for TC (IVW: Q = 44.503), LDL (IVW: Q = 33.450), TG (IVW: Q = 159.645) and FBG (IVW: Q = 0. 32.132). An analysis of MR-PRESSO and radial plots did not highlight any outliers. The results of the leave-one-out method demonstrated that the links were not driven by a single instrument. Conclusions: We did not find any effect of mannose on adiposity, glucose, TC, LDL, TG and CAD.<\/jats:p>","DOI":"10.3390\/nu13082563","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T03:53:53Z","timestamp":1627358033000},"page":"2563","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetically Higher Level of Mannose Has No Impact on Cardiometabolic Risk Factors: Insight from Mendelian Randomization"],"prefix":"10.3390","volume":"13","author":[{"given":"Mohsen","family":"Mazidi","sequence":"first","affiliation":[{"name":"Medical Research Council Population Health Research Unit, University of Oxford, Oxford OX3 7LF, UK"},{"name":"Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK"},{"name":"Department of Twin Research & Genetic Epidemiology, King\u2019s College London, South Wing St Thomas\u2019, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Dehghan","sequence":"additional","affiliation":[{"name":"MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Banach","sequence":"additional","affiliation":[{"name":"Department of Preventive Cardiology and Lipidology, Chair of Nephrology and Hypertension, Medical University of Lodz, 93-338 Lodz, Poland"},{"name":"Cardiovascular Research Centre, University of Zielona Gora, 65-046 Zielona Gora, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Lipid and Blood Pressure Meta-Analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/glycob\/8.3.285","article-title":"Direct utilization of mannose for mammalian glycoprotein biosynthesis","volume":"8","author":"Alton","year":"1998","journal-title":"Glycobiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/1541-4337.12211","article-title":"D-Mannose: Properties, production, and applications: An overview","volume":"15","author":"Hu","year":"2016","journal-title":"Compr. 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