{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:43:02Z","timestamp":1791855782414,"version":"4.3.4"},"reference-count":87,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Several studies link cardiovascular diseases (CVD) with unhealthy lifestyles (unhealthy dietary habits, alcohol consumption, smoking, and low levels of physical activity). Therefore, the strong need for CVD prevention may be pursued through an improved control of CVD risk factors (impaired lipid and glycemic profiles, high blood pressure, and obesity), which is achievable through an overall intervention aimed to favor a healthy lifestyle. Focusing on diet, different recommendations emphasize the need to increase or avoid consumption of entire classes of food, with only partly known and only partly foreseeable consequences on the overall level of health. In recent years, the ketogenic diet (KD) has been proposed to be an effective lifestyle intervention for metabolic syndrome, and although the beneficial effects on weight loss and glucose metabolism seems to be well established, the effects of a prolonged KD on the ability to perform different types of exercise and the influence of KD on blood pressure (BP) levels, both in normotensives and in hypertensives, are not so well understood. The objective of this review is to analyze, on the basis of current evidence, the relationship between KD, regular physical activity, and BP.<\/jats:p>","DOI":"10.3390\/nu13082567","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T12:18:31Z","timestamp":1627388311000},"page":"2567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Ketogenic Diet, Physical Activity, and Hypertension\u2014A Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4529-3703","authenticated-orcid":false,"given":"Domenico","family":"Di Raimondo","sequence":"first","affiliation":[{"name":"Department of Promoting Health, Maternal-Infant. Excellence and Internal and Specialized Medicine (Promise) G. D\u2019Alessandro, University of Palermo, 90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0730-7649","authenticated-orcid":false,"given":"Silvio","family":"Buscemi","sequence":"additional","affiliation":[{"name":"Department of Promoting Health, Maternal-Infant. Excellence and Internal and Specialized Medicine (Promise) G. D\u2019Alessandro, University of Palermo, 90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Musiari","sequence":"additional","affiliation":[{"name":"Department of Promoting Health, Maternal-Infant. Excellence and Internal and Specialized Medicine (Promise) G. D\u2019Alessandro, University of Palermo, 90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Department of Promoting Health, Maternal-Infant. Excellence and Internal and Specialized Medicine (Promise) G. D\u2019Alessandro, University of Palermo, 90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-7405","authenticated-orcid":false,"given":"Edoardo","family":"Pirera","sequence":"additional","affiliation":[{"name":"Department of Promoting Health, Maternal-Infant. Excellence and Internal and Specialized Medicine (Promise) G. D\u2019Alessandro, University of Palermo, 90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9261-4469","authenticated-orcid":false,"given":"Davide","family":"Corleo","sequence":"additional","affiliation":[{"name":"Department of Promoting Health, Maternal-Infant. Excellence and Internal and Specialized Medicine (Promise) G. D\u2019Alessandro, University of Palermo, 90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Promoting Health, Maternal-Infant. Excellence and Internal and Specialized Medicine (Promise) G. D\u2019Alessandro, University of Palermo, 90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Tuttolomondo","sequence":"additional","affiliation":[{"name":"Department of Promoting Health, Maternal-Infant. Excellence and Internal and Specialized Medicine (Promise) G. 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Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1542\/peds.2006-2447","article-title":"The ketogenic diet: One decade later","volume":"119","author":"Freeman","year":"2007","journal-title":"Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11892-018-1103-4","article-title":"Fat versus carbohydrate-based energy-restricted diets for weight loss in patients with type 2 diabetes","volume":"18","author":"Hamdy","year":"2018","journal-title":"Curr. Diabetes Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2362.2009.02091.x","article-title":"Effects of hypocaloric very-low-carbohydrate diet vs. Mediterranean diet on endothelial function in obese women","volume":"39","author":"Buscemi","year":"2009","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s00394-018-1636-y","article-title":"Overweight and diabetes prevention: Is a low-carbohydrate\u2013high-fat diet recommendable?","volume":"57","author":"Brouns","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/s13668-019-00294-0","article-title":"Ketogenic Diet: From the Historical Records to Use in Elite Athletes","volume":"8","author":"Kaspar","year":"2019","journal-title":"Curr. Nutr. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ruiz, L.D., Zuelch, M.L., Dimitratos, S.M., and Scherr, R.E. (2019). Adolescent Obesity: Diet Quality, Psychosocial Health, and Cardiometabolic Risk Factors. Nutrients, 12.","DOI":"10.3390\/nu12010043"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/ijcp.12269","article-title":"Metabolic and anti-inflammatory effects of a home-based programme of aerobic physical exercise","volume":"67","author":"Tuttolomondo","year":"2013","journal-title":"Int. J. Clin. Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s13668-019-00297-x","article-title":"Ketogenic Diet: An Endocrinologist Perspective","volume":"8","author":"Kuchkuntla","year":"2019","journal-title":"Curr. Nutr. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1042\/BJ20111416","article-title":"Glycogen and its metabolism: Some new developments and old themes","volume":"441","author":"Roach","year":"2012","journal-title":"Biochem. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-7075-1-2","article-title":"Ketogenic diets and physical performance","volume":"1","author":"Phinney","year":"2004","journal-title":"Nutr. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/152165401753311780","article-title":"Ketone bodies, potential therapeutic uses","volume":"51","author":"Veech","year":"2001","journal-title":"IUBMB Life"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.brainresrev.2008.09.002","article-title":"The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies","volume":"59","author":"Maalouf","year":"2009","journal-title":"Brain Res. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fphar.2012.00059","article-title":"The ketogenic diet as a treatment paradigm for diverse neurological disorders","volume":"3","author":"Stafstrom","year":"2012","journal-title":"Front. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fnmol.2018.00015","article-title":"How Can a Ketogenic Diet Improve Motor Function?","volume":"11","author":"Reynier","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Valenzano, A., Polito, R., Trimigno, V., Di Palma, A., Moscatelli, F., Corso, G., Sessa, F., Salerno, M., Montana, A., and Di Nunno, N. (2019). Effects of Very Low Calorie Ketogenic Diet on the Orexinergic System, Visceral Adipose Tissue, and ROS Production. Antioxidants, 8.","DOI":"10.3390\/antiox8120643"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s12020-016-1050-2","article-title":"Obesity treatment by very low-calorie-ketogenic diet at two years: Reduction in visceral fat and on the burden of disease","volume":"54","author":"Moreno","year":"2016","journal-title":"Endocrine"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/WCO.0000000000000432","article-title":"New insights into the mechanisms of the ketogenic diet","volume":"30","author":"Boison","year":"2017","journal-title":"Curr. Opin. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e4488","DOI":"10.7717\/peerj.4488","article-title":"The use of nutritional supplements to induce ketosis and reduce symptoms associated with keto-induction: A narrative review","volume":"6","author":"Harvey","year":"2018","journal-title":"PeerJ"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.12659\/AJCR.917226","article-title":"Starvation Ketoacidosis due to the Ketogenic Diet and Prolonged Fasting\u2014A Possibly Dangerous Diet Trend","volume":"20","author":"Blanco","year":"2019","journal-title":"Am. J. Case Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnut.2020.00020","article-title":"Consumer Reports of \u201cKeto Flu\u201d Associated With the Ketogenic Diet","volume":"7","author":"Bostock","year":"2020","journal-title":"Front. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.atherosclerosis.2020.09.015","article-title":"The ketogenic diet: Pros and cons","volume":"292","author":"Raggi","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.7326\/0003-4819-153-5-201009070-00003","article-title":"Low-carbohydrate diets and all-cause and cause-specific mortality: Two cohort studies","volume":"153","author":"Fung","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.20899","article-title":"Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet","volume":"60","author":"Bough","year":"2006","journal-title":"Ann. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1096\/fj.11-200410","article-title":"Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet","volume":"26","author":"Srivastava","year":"2012","journal-title":"FASEB J."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Gama, G., Farinatti, P., Rangel, M.V.D.S., Mira, P.A.C., Laterza, M.C., Crisafulli, A., and Borges, J.P. (2021). Muscle metaboreflex adaptations to exercise training in health and disease. Eur. J. Appl Physiol., online ahead of print.","DOI":"10.1007\/s00421-021-04756-8"},{"key":"ref_28","unstructured":"Riebe, D., Ehrman, J.K., Liguori, G., and Magal, M. (2018). ACM\u2019s Guidelines for Exercise Testing and Prescription, Wolters Kluwer. [10th ed.]."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Harvey, K.L., Holcomb, L.E., and Kolwicz, S.C. (2019). Ketogenic Diets and Exercise Performance. Nutrients, 11.","DOI":"10.3390\/nu11102296"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2165\/00007256-200131100-00003","article-title":"Energy system interaction and relative contribution during maximal exercise","volume":"31","author":"Gastin","year":"2001","journal-title":"Sports Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Feuerbacher, J.F., von Sch\u00f6ning, V., Melcher, J., Notbohm, H.L., Freitag, N., and Schumann, M. (2021). Short-Term Creatine Loading Improves Total Work and Repetitions to Failure but Not Load-Velocity Characteristics in Strength-Trained Men. Nutrients, 13.","DOI":"10.3390\/nu13030826"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.21037\/atm.2017.07.30","article-title":"New insights about the putative role of myokines in the context of cardiac rehabilitation and secondary cardiovascular prevention","volume":"5","author":"Miceli","year":"2017","journal-title":"Ann. Transl. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s40279-015-0365-0","article-title":"Effectiveness of High-Intensity Interval Training (HIT) and Continuous Endurance Training for VO2max Improvements: A Systematic Review and Meta-Analysis of Controlled Trials","volume":"45","author":"Weston","year":"2015","journal-title":"Sports Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/sms.13493","article-title":"Oxygen uptake plateau occurrence depends on oxygen kinetics and oxygen deficit accumulation","volume":"29","author":"Niemeyer","year":"2019","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1249\/JSR.0000000000000542","article-title":"Effects of Ketone Bodies on Endurance Exercise","volume":"17","author":"Sansone","year":"2018","journal-title":"Curr. Sports Med. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2016.08.021","article-title":"Fueling performance: Ketones enter the mix","volume":"24","author":"Egan","year":"2016","journal-title":"Cell Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.metabol.2015.10.028","article-title":"Metabolic Characteristics of Keto-Adapted Ultra-Endurance Runners","volume":"65","author":"Volek","year":"2016","journal-title":"Metabolism"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1113\/JP273230","article-title":"Low Carbohydrate, High Fat Diet Impairs Exercise Economy and Negates the Performance Benefit from Intensified Training in Elite Race Walkers","volume":"595","author":"Burke","year":"2017","journal-title":"J. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Carr, A.J., Sharma, A.P., Ross, M.L., Welvaert, M., Slater, G.J., and Burke, L.M. (2018). Chronic Ketogenic Low Carbohydrate High Fat Diet Has Minimal effects on Acid-Base Status in Elite Athletes. Nutrients, 10.","DOI":"10.3390\/nu10020236"},{"key":"ref_40","first-page":"259","article-title":"Effects of a 4-Week Very Low-Carbohydrate Diet on High-Intensity Interval Training Responses","volume":"17","author":"Cipryan","year":"2018","journal-title":"J. Sports Sci. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12970-019-0284-9","article-title":"Effect of a Four-Week Ketogenic Diet on Exercise Metabolism in Crossfit-Trained Athletes","volume":"16","author":"Nowaczyk","year":"2019","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Kephart, W.C., Pledge, C.D., Roberson, P.A., Mumford, P.W., Romero, M.A., Mobley, C.B., Martin, J.S., Young, K.C., Lowery, R.P., and Wilson, J.M. (2018). The Three-Month Effects of a Ketogenic Diet on Body Composition, Blood Parameters, and Performance Metrics in Crossfit Trainees: A Pilot Study. Sports, 6.","DOI":"10.3390\/sports6010001"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.metabol.2017.10.010","article-title":"Keto-Adaptation Enhances Exercise Performance and Body Composition Responses to Training in Endurance Athletes","volume":"81","author":"McSwiney","year":"2018","journal-title":"Metabolism"},{"key":"ref_44","first-page":"786","article-title":"Effects of a 3-Week High-Fat-Low-Carbohydrate Diet on Lipid and Glucose Profiles in Experienced, Middle-Age Male Runners","volume":"12","author":"Smith","year":"2019","journal-title":"Int. J. Exerc. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1249\/MSS.0000000000002008","article-title":"Effect of a Ketogenic Diet on Submaximal Exercise Capacity and Efficiency in Runners","volume":"51","author":"Shaw","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.3390\/nu6072493","article-title":"The Effects of a Ketogenic Diet on Exercise Metabolism and Physical Performance in Off-Road Cyclists","volume":"6","author":"Zajac","year":"2014","journal-title":"Nutrients"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s12970-017-0180-0","article-title":"Ketogenic Diet Benefits Body Composition and Well-Being but Not Performance in a Pilot Case Study of New Zealand Endurance Athletes","volume":"14","author":"Zinn","year":"2017","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12970-020-00362-9","article-title":"A review of the ketogenic diet for endurance athletes: Performance enhancer or placebo effect?","volume":"17","author":"Bailey","year":"2020","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1080\/09638288.2018.1527953","article-title":"Structured clinical reasoning for exercise prescription in patients with comorbidity","volume":"42","author":"Stuiver","year":"2020","journal-title":"Disabil. Rehabil."},{"key":"ref_50","first-page":"600","article-title":"Low-carbohydrate, ketogenic diet impairs anaerobic exercise performance in exercise-trained women and men: A randomized-sequence crossover trial","volume":"59","author":"Wroble","year":"2019","journal-title":"J. Sports Med. Phys. Fit."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"54","DOI":"10.23937\/2469-5718\/1510054","article-title":"A Low-Carbohydrate Ketogenic Diet Combined with 6-Weeks of Crossfit Training Improves Body Composition and Performance","volume":"3","author":"Gregory","year":"2017","journal-title":"Int. J. Sports Exerc. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1097\/HJH.0000000000001961","article-title":"2018 Practice Guidelines for the management of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology: ESH\/ESC Tas k Force for the Management of Arterial Hypertension","volume":"36","author":"Williams","year":"2018","journal-title":"J. Hypertens."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"118124","DOI":"10.1016\/j.lfs.2020.118124","article-title":"Ketogenic diet aggravates hypertension via NF-\u03baB-mediated endothelial dysfunction in spontaneously hypertensive rats","volume":"258","author":"Guo","year":"2020","journal-title":"Life Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11906-018-0812-z","article-title":"The Global Epidemic of the Metabolic Syndrome","volume":"20","author":"Saklayen","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1056\/NEJM200101043440101","article-title":"DASH-Sodium Collaborative Research Group. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group","volume":"344","author":"Sacks","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2337\/diacare.27.2.538","article-title":"Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort","volume":"27","author":"McKeown","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.clnu.2013.11.003","article-title":"Diets and nonalcoholic fatty liver disease: The good and the bad","volume":"33","author":"Asrih","year":"2014","journal-title":"Clin. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Taskinen, M.R., Packard, C.J., and Bor\u00e9n, J. (2019). Dietary Fructose and the Metabolic Syndrome. Nutrients, 11.","DOI":"10.3390\/nu11091987"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1743-7075-2-31","article-title":"Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction","volume":"2","author":"Volek","year":"2005","journal-title":"Nutr. Metab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.plipres.2008.02.003","article-title":"Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome","volume":"47","author":"Volek","year":"2008","journal-title":"Prog. Lipid Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11745-008-3274-2","article-title":"Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet","volume":"44","author":"Volek","year":"2009","journal-title":"Lipids"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1056\/NEJMoa022637","article-title":"A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity","volume":"348","author":"Samaha","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1056\/NEJMoa022207","article-title":"A Randomized Trial of a Low-Carbohydrate Diet for Obesity","volume":"348","author":"Foster","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/jama.293.1.43","article-title":"Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: A randomized trial","volume":"293","author":"Dansinger","year":"2005","journal-title":"JAMA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/bmj.38833.411204.80","article-title":"Randomised controlled trial of four commercial weight loss programmes in the UK: Initial findings from the BBC \u201cdiet trials\u201d","volume":"332","author":"Truby","year":"2006","journal-title":"BMJ"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1001\/jama.297.9.969","article-title":"Comparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: The A TO Z Weight Loss Study: A randomized trial","volume":"297","author":"Gardner","year":"2007","journal-title":"JAMA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1001\/archinternmed.2009.492","article-title":"A randomized trial of a low-carbohydrate diet vs orlistat plus a low-fat diet for weight loss","volume":"170","author":"Yancy","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.numecd.2009.05.003","article-title":"Long-term effects of a low carbohydrate, low fat or high unsaturated fat diet compared to a no-intervention control","volume":"20","author":"Lim","year":"2010","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"147","DOI":"10.7326\/0003-4819-153-3-201008030-00005","article-title":"Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: A randomized trial","volume":"153","author":"Foster","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1017\/S0007114513000640","article-title":"Effects of a low-carbohydrate diet on weight loss and cardiometabolic profile in Chinese women: A randomised controlled feeding trial","volume":"110","author":"Liu","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"309","DOI":"10.7326\/M14-0180","article-title":"Effects of low-carbohydrate and low-fat diets: A randomized trial","volume":"161","author":"Bazzano","year":"2014","journal-title":"Ann. Intern. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s40292-015-0096-1","article-title":"Middle and Long-Term Impact of a Very Low-Carbohydrate Ketogenic Diet on Cardiometabolic Factors: A Multi-Center, Cross-Sectional, Clinical Study","volume":"22","author":"Cicero","year":"2015","journal-title":"High Blood Press. Cardiovasc. Prev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1001\/jama.289.14.1837","article-title":"Efficacy and safety of low-carbohydrate diets: A systematic review","volume":"289","author":"Bravata","year":"2003","journal-title":"JAMA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1467-789X.2008.00518.x","article-title":"Systematic review of randomized controlled trials of low-carbohydrate vs. low-fat\/low-calorie diets in the management of obesity and its comorbidities","volume":"10","author":"Hession","year":"2009","journal-title":"Obes. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/j.1467-789X.2012.01021.x","article-title":"Systematic review and meta-analysis of clinical trials of the effects of low carbohydrate diets on cardiovascular risk factors","volume":"13","author":"Santos","year":"2012","journal-title":"Obes. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.2174\/1381612822666160510125011","article-title":"Preventive and Therapeutic Role of Muscle Contraction against Chronic Diseases","volume":"22","author":"Musiari","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1210\/jc.2018-02507","article-title":"Endothelial function, adipokine serum levels and white matter hyperintesities in subjects with diabetic foot syndrome","volume":"104","author":"Tuttolomondo","year":"2019","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13063-018-2462-5","article-title":"The effect of a ketogenic diet versus a high-carbohydrate, low-fat diet on sleep, cognition, thyroid function, and cardiovascular health independent of weight loss: Study protocol for a randomized controlled trial","volume":"19","author":"Iacovides","year":"2018","journal-title":"Trials"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1096\/fj.201601125RRR","article-title":"Molecular mechanisms underlying metabolic syndrome: The expanding role of the adipocyte","volume":"31","author":"Armani","year":"2017","journal-title":"FASEB J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s40618-019-01061-2","article-title":"Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: Systematic review and consensus statement from the Italian Society of Endocrinology (SIE)","volume":"42","author":"Caprio","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Karwi, Q.G., and Lopaschuk, G.D. (2021). CrossTalk proposal: Ketone bodies are an important metabolic fuel for the heart. J. Physiol., Online ahead of print.","DOI":"10.1113\/JP281004"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/MCO.0000000000000475","article-title":"Ketone bodies as epigenetic modifiers","volume":"21","author":"Ruan","year":"2018","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"8030","DOI":"10.1073\/pnas.1016088108","article-title":"Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)","volume":"108","author":"Kimura","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1111\/dom.13488","article-title":"Increases in circulating levels of ketone bodies and cardiovascular protection with SGLT2 inhibitors: Is low-grade inflammation the neglected component?","volume":"20","author":"Prattichizzo","year":"2018","journal-title":"Diabetes Obes. Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.metabol.2017.08.005","article-title":"The diabetic heart utilizes ketone bodies as an energy source","volume":"77","author":"Mizuno","year":"2017","journal-title":"Metabolism"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1001\/jama.2021.8789","article-title":"Ketone Body Supplementation\u2014A Potential New Approach for Heart Disease","volume":"326","author":"Abbasi","year":"2021","journal-title":"JAMA"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/8\/2567\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:35:32Z","timestamp":1760164532000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/8\/2567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,27]]},"references-count":87,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["nu13082567"],"URL":"https:\/\/doi.org\/10.3390\/nu13082567","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,27]]}}}