{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T02:30:15Z","timestamp":1782527415961,"version":"3.54.5"},"reference-count":90,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Pomegranate juice (Punica granatum) has been used since ancient times in traditional medicine (Unani Medicine, Ayurveda); its main compounds are anthocyanins and ellagic acid, which have anti-inflammatory, antioxidant, hepatoprotective, and cardiovascular health effects. The objective was to evaluate the effect of pomegranate juice on inflammation, blood pressure, and vascular and physiological markers associated with obesity induced by a high-fat diet in a murine model. The results show that pomegranate juice reduces the concentration of low-density lipoprotein cholesterol (cLDL) 39% and increases the concentration of high-density lipoprotein cholesterol (cHDL) by 27%, leading to a 12%\u201318% decrease in the risk of cardiovascular diseases (CVD). In addition to reducing blood pressure by 24%, it also had an antiatherogenic effect by decreasing sE-selectin levels by 42%. On the other hand, the juice significantly increased adiponectin levels in adipose tissue, decreased levels of inflammation markers (tumor necrosis factor-\u03b1 (TNF-\u03b1), plasminogen activator inhibitor-1 (PAI-1), interleukin-17A (IL-17A), interleukin-6 (IL-6), interleukin-1\u03b2 (IL-1\u03b2)), and inhibited the monocyte chemoattractant protein-1 (MCP-1). Pomegranate juice requires clinical studies to prove its immunoregulatory and therapeutic effects on cardiovascular and atherogenic risks.<\/jats:p>","DOI":"10.3390\/nu13082577","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T12:18:31Z","timestamp":1627388311000},"page":"2577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Inflammation Markers in Adipose Tissue and Cardiovascular Risk Reduction by Pomegranate Juice in Obesity Induced by a Hypercaloric Diet in Wistar Rats"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9842-5562","authenticated-orcid":false,"given":"Maria Monica","family":"Michicotl-Meneses","sequence":"first","affiliation":[{"name":"Departamento de Ingenier\u00eda Bioqu\u00edmica, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Ciencias Biol\u00f3gicas, Mexico City 07738, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda del Roc\u00edo","family":"Thompson-Bonilla","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Gen\u00f3mica, Investigaci\u00f3n Biom\u00e9dica y Traslacional, ISSSTE, Hospital Regional \u201c1\u00b0 de Octubre\u201d, Mexico City 07760, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-8983","authenticated-orcid":false,"given":"C\u00e9sar A.","family":"Reyes-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Bioqu\u00edmica Estructural, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Medicina y Homeopat\u00eda, Mexico City 07320, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6610-5559","authenticated-orcid":false,"given":"Blanca Estela","family":"Garc\u00eda-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda General, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Ciencias Biol\u00f3gicas, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itzel I.","family":"L\u00f3pez-Tenorio","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Bioqu\u00edmica, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Ciencias Biol\u00f3gicas, Mexico City 07738, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0938-3365","authenticated-orcid":false,"given":"Cynthia","family":"Ordaz-Pichardo","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Celular y Productos Naturales, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Medicina y Homeopat\u00eda, Mexico City 07320, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Jaramillo-Flores","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda Bioqu\u00edmica, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Ciencias Biol\u00f3gicas, Mexico City 07738, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1017\/S1368980007000663","article-title":"Inflammation, obesity and comorbidities: The role of diet","volume":"10","author":"Aranceta","year":"2007","journal-title":"Public Health Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Jarolimova, J., Tagoni, J., and Stern, T.A. 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