{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:36Z","timestamp":1787029176442,"version":"build-2736575974"},"reference-count":34,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>So far, there is no consistent and convincing theory explaining the pathogenesis of migraines. Vascular disorders, the effect of oxidative stress on neurons, and the contribution of magnesium-calcium deficiencies in triggering cortical depression and abnormal glutaminergic neurotransmission are taken into account. However, there are no reliable publications confirming the role of dietary deficits of magnesium and latent tetany as factors triggering migraine attacks. The aim of the study was to evaluate the influence of latent magnesium deficiency assessed with the electrophysiological tetany test on the course of migraine. The study included: a group of 35 patients (29 women and six men; in mean age 41 years) with migraine and a control group of 24 (17 women and seven men; in mean age 39 years) healthy volunteers. Migraine diagnosis was based on the International Headache Society criteria, 3rd edition. All patients and controls after full general and neurological examination were subjected to a standard electrophysiological ischemic tetany test. Moreover, the level of magnesium in blood serum was tested and was in the normal range in all patients. Then, the incidence of a positive tetany EMG test results in the migraine group and the results in the subgroups with and without aura were compared to the results in the control group. Moreover, the relationship between clinical markers of spasmophilia and the results of the tetany test was investigated in the migraine group. As well as the relationship between migraine frequency and tetany test results. There was no statistically significant difference in the occurrence of the electrophysiological exponent of spasmophilia between the migraine and control group. Neither correlation between the occurrence of clinical symptoms nor the frequency of migraine attacks and the results of the tetany test was stated (p &gt; 0.05). However, there was an apparent statistical difference between the subgroup of migraine patients with aura in relation to the control group (p &lt; 0.05). The result raises hope to find a trigger for migraine attacks of this clinical form, the more that this factor may turn out to be easy to supplement with dietary supplementation.<\/jats:p>","DOI":"10.3390\/nu13082701","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T09:35:32Z","timestamp":1628156132000},"page":"2701","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Migraine and Its Association with Hyperactivity of Cell Membranes in the Course of Latent Magnesium Deficiency\u2014Preliminary Study of the Importance of the Latent Tetany Presence in the Migraine Pathogenesis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-3285","authenticated-orcid":false,"given":"Joanna","family":"Cegielska","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences, Medical University of Warsaw, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Szmidt-Sa\u0142kowska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Domitrz","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics and Information Science, Warsaw University of Technology, 00-662 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Gawe\u0142","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medicine, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Radziwo\u0144-Zaleska","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Faculty of Medicine, Medical University of Warsaw, 00-685 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3130-1036","authenticated-orcid":false,"given":"Izabela","family":"Domitrz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Medical Sciences, Medical University of Warsaw, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2174\/1874205X00903010064","article-title":"Migraine: An Overview","volume":"3","author":"Salomone","year":"2009","journal-title":"Open Neurol. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s13311-018-0616-5","article-title":"Glutamate and Its Receptors as Therapeutic Targets for Migraine","volume":"15","author":"Hoffmann","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ncl.2019.07.008","article-title":"Pathophysiology of Migraine: An Update","volume":"37","author":"Goadsby","year":"2019","journal-title":"Neurol. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/ana.410090406","article-title":"Focal Hyperemia Followed by Spreading Oligemia and Impaired Activation of rCBF in Classic Migraine","volume":"9","author":"Olesen","year":"1981","journal-title":"Ann. Neurol."},{"key":"ref_5","unstructured":"Ekbom, K. (1993). Pathophysiology of migraine. Migraine in General Practice, Smith-Gordon."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archneur.1988.00520260040017","article-title":"Delayed Hyperemia Following Hypoperfusion in Classic Migraine. Single Photon Emission Computed Tomographic Demonstration","volume":"45","author":"Andersen","year":"1988","journal-title":"Arch. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/ana.10158","article-title":"Cortical Spreading Depression and Gene Regulation: Revalance to Migraine","volume":"51","author":"Choudhuri","year":"2002","journal-title":"Ann. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1161\/01.STR.23.5.680","article-title":"Transcranial Doppler in Spontaneus Attacks of Migraine","volume":"23","author":"Zanette","year":"1992","journal-title":"Stroke"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1056\/NEJM199412223312505","article-title":"Bilateral spreading cerebral hypoperfusion during spontaneous migraine headache","volume":"331","author":"Woods","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1056\/NEJM199506013322214","article-title":"Spreading Cerebral Hypoperfusion during Migraine Headache","volume":"332","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/jnnp.73.2.202","article-title":"Prolonged hemiplegic migraine associated with unilateral hyperperfusion on perfusion weighted magnetic resonance imaging","volume":"73","author":"Lindahl","year":"2002","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1177\/0333102417724151","article-title":"Initiation of spreading depression by synaptic and network hyperactivity: Insights into trigger mechanisms of migraine aura","volume":"38","author":"Vinogradova","year":"2018","journal-title":"Cephalalgia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1152\/ajplegacy.1956.184.2.312","article-title":"Spreading depression in rabbit, cat and monkey","volume":"184","author":"Stamm","year":"1956","journal-title":"Am. J. Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJM199412223312510","article-title":"Understanding the biologic basis of migraine","volume":"331","author":"Olesen","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/syn.21769","article-title":"Propagation of cortical spreading depression into the hippocampus: The role of the entorhinal cortex","volume":"68","author":"Speckmann","year":"2014","journal-title":"Synapse"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1212\/WNL.58.8.1227","article-title":"Contrasts in cortical magnesium, phospholipid and energy metabolism between migraine syndromes","volume":"58","author":"Boska","year":"2002","journal-title":"Neurology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1046\/j.1526-4610.1997.3709561.x","article-title":"Platelet Jonized Magnezium, Cyclic AMP, and Cyclic GMP Levels in Migraine and Tension-Type Headache","volume":"37","author":"Mishima","year":"1997","journal-title":"Headache"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/bmj.318.7175.13","article-title":"Migraine and stroke in young women: Case-control study","volume":"318","author":"Chang","year":"1999","journal-title":"BMJ"},{"key":"ref_19","first-page":"4143","article-title":"Distinct vascular conduction with cortical spreading depression","volume":"97","author":"Brennan","year":"2007","journal-title":"J. Neuropsiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1177\/033310240102100704","article-title":"Cortical spreading depression in migraine","volume":"21","author":"Lauritzen","year":"2001","journal-title":"Cephalalgia"},{"key":"ref_21","unstructured":"Olesen, J., Goadsby, P.J., Ramadan, N.M., Tfel-Hansen, P., and Welch, K.M.A. (2006). Hemodynamics and neuroimaging of migraines. The Headaches, Lippincott Williams & Wilkins. [3rd ed.]."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Dolati, S., Rikhtegar, R., Mehdizadeh, A., and Yousefi, M. (2019). The Role of Magnesium in Pathophysiology and Migraine Treatment. Biol. Trace Elem. Res.","DOI":"10.1007\/s12011-019-01931-z"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Kirkland, A.E., Sarlo, G.L., and Holton, K.F. (2018). The Role of Magnesium in Neurological Disorders. Nutrients, 10.","DOI":"10.3390\/nu10060730"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) (2018). The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 38, 1\u2013211.","DOI":"10.1177\/0333102417738202"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1085\/jgp.39.5.753","article-title":"The effect of external calcium and magnesium depletion on single nerve fibers","volume":"39","author":"Adelman","year":"1956","journal-title":"J. Gen. Physiol."},{"key":"ref_26","first-page":"47","article-title":"Magnesium Metabolism and its Disorders","volume":"24","author":"Swaminathan","year":"2003","journal-title":"Clin. Biochem. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Faheemuddin, A., and Abdul, M. (2019). Magnesium: The Forgotten Electrolyte\u2014A Review on Hypomagnesemia. Med. Sci., 7.","DOI":"10.3390\/medsci7040056"},{"key":"ref_28","first-page":"448","article-title":"Magnesium balance in patients with spasmophilia. Relation to results of electromyography","volume":"136","author":"Bartousek","year":"1997","journal-title":"Cas. Lek. Cesk."},{"key":"ref_29","first-page":"461","article-title":"Latent tetany and anxiety, marginal magnesium deficit, and normocalcemia","volume":"36","author":"Seelig","year":"1975","journal-title":"Dis. Nerv. Syst."},{"key":"ref_30","first-page":"169","article-title":"Neurotic, neuromuscular and autonomic nervous form of magnesium imbalance","volume":"10","author":"Durlach","year":"1997","journal-title":"Magnes. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1526-4610.2002.02075.x","article-title":"Serum Ionized Magnesium Levels and Serum Ionized Calcium\/Ionized Magnesium Ratios in Women With Menstrual Migraine","volume":"42","author":"Mauskop","year":"2002","journal-title":"Headache"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0022-510X(95)00196-1","article-title":"Mitochondria, magnesium and migraine","volume":"134","author":"Welch","year":"1995","journal-title":"J. Neurol. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1526-4610.1989.hed2909590.x","article-title":"Low brain magnesium in migraine","volume":"29","author":"Ramadan","year":"1989","journal-title":"Headache"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1046\/j.1526-4610.1997.3706383.x","article-title":"Visual Evoked Potentials and Serum Magnesium Levels in Juvenile Migraine Patients","volume":"37","author":"Aloisi","year":"1997","journal-title":"Headache"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/8\/2701\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:40:55Z","timestamp":1760164855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/8\/2701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,5]]},"references-count":34,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["nu13082701"],"URL":"https:\/\/doi.org\/10.3390\/nu13082701","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,5]]}}}