{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:11:50Z","timestamp":1789182710954,"version":"build-2803163510"},"reference-count":51,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001870","name":"Fundacja na rzecz Nauki Polskiej","doi-asserted-by":"publisher","award":["POIR.04.04.00-00-679 420C\/17-00"],"award-info":[{"award-number":["POIR.04.04.00-00-679 420C\/17-00"]}],"id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005888","name":"Uniwersytet Medyczny w Lodzi","doi-asserted-by":"publisher","award":["503\/1-156-04\/503-11-001"],"award-info":[{"award-number":["503\/1-156-04\/503-11-001"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diet is considered an important trigger in inflammatory bowel diseases (IBD), as feeding habits can affect intestinal permeability and clearance of bacterial antigens, consequently influencing the immune system. Free fatty acid receptors (FFARs), expressed on the intestinal epithelial cells, belong to the family of luminal-facing receptors that are responsive to nutrients. The objective of this study was to characterize the anti-inflammatory activity and the effect on intestinal barrier function of synthetic FFAR agonists in mouse models of colitis. Therapeutic activity of GW9508 (FFAR1 agonist), 4-CMTB (FFAR2 agonist), AR420626 (FFAR3 agonist), and GSK137647 (FFAR4 agonist) was investigated in two models of semi-chronic colitis: induced by trinitrobenzenesulfonic acid (TNBS), mimicking Crohn\u2019s disease, as well as induced by dextran sulfate sodium (DSS), which recapitulates ulcerative colitis in humans. Moreover, we assessed the influence of FFARs agonists on epithelial ion transport and measured the ion flow stimulated by forskolin and veratridine. Administration of FFAR4 agonist GSK137647 attenuated both TNBS-induced and DSS-induced colitis in mice, as indicated by macroscopic parameters and myeloperoxidase activity. The action of FFAR4 agonist GSK137647 was significantly blocked by pretreatment with selective FFAR4 antagonist AH7614. Moreover, FFAR1 and FFAR4 agonists reversed the increase in the colon permeability caused by inflammation. FFAR4 restored the tight junction genes expression in mouse colon. This is the first evaluation of the anti-inflammatory activity of selective FFAR agonists, showing that pharmacological intervention targeting FFAR4, which is a sensor of medium and long chain fatty acids, attenuates intestinal inflammation.<\/jats:p>","DOI":"10.3390\/nu13082716","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T21:35:40Z","timestamp":1628458540000},"page":"2716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Activation of Free Fatty Acid Receptor 4 Affects Intestinal Inflammation and Improves Colon Permeability in Mice"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-8749","authenticated-orcid":false,"given":"Maciej","family":"Salaga","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-7320","authenticated-orcid":false,"given":"Adrian","family":"Bartoszek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-2966","authenticated-orcid":false,"given":"Agata","family":"Binienda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia B.","family":"Krajewska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6997-4925","authenticated-orcid":false,"given":"Adam","family":"Fabisiak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"},{"name":"Department of Digestive Tract Diseases, Medical University of Lodz, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Mosi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Dziedziczak","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Niewinna","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8685-1161","authenticated-orcid":false,"given":"Marcin","family":"Talar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Tarasiuk","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radzis\u0142aw","family":"Kordek","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-4417","authenticated-orcid":false,"given":"Jakub","family":"Fichna","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6\/8, 92-215 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.drudis.2013.03.004","article-title":"Inhibition of proteases as a novel therapeutic strategy in the treatment of metabolic, inflammatory and functional diseases of the gastrointestinal tract","volume":"18","author":"Sobczak","year":"2013","journal-title":"Drug Discov. Today"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104604","DOI":"10.1016\/j.phrs.2019.104604","article-title":"Free Fatty Acid Receptors as new potential therapeutic target in inflammatory bowel diseases","volume":"152","author":"Bartoszek","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.pharep.2014.04.005","article-title":"Current overview of extrinsic and intrinsic factors in etiology and progression of inflammatory bowel diseases","volume":"66","author":"Sobczak","year":"2014","journal-title":"Pharmacol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cbpb.2009.08.005","article-title":"Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: Comparison with human GPR120 splice variants","volume":"154","author":"Moore","year":"2009","journal-title":"Comp. Biochem. Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.bbrc.2010.05.057","article-title":"Biochemical and Biophysical Research Communications Agonism with the omega-3 fatty acids a -linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor","volume":"396","author":"Burns","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/chemse\/bjr069","article-title":"G Protein\u2014Coupled Receptors in Human Fat Taste Perception","volume":"37","author":"Galindo","year":"2012","journal-title":"Chem. Senses"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"21131","DOI":"10.1074\/jbc.M115.644450","article-title":"\u03b2-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1","volume":"290","author":"Mancini","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"17296","DOI":"10.1074\/jbc.M113.455337","article-title":"Defining the Molecular Basis for the First Potent and Selective Orthosteric Agonists of the FFA2 Free Fatty Acid Receptor","volume":"288","author":"Hudson","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1124\/mol.111.077388","article-title":"Differential Signaling by Splice Variants of the Human Free Fatty Acid Receptor GPR120","volume":"81","author":"Watson","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/MCO.0b013e32834f4598","article-title":"G-protein-coupled receptors as fat sensors","volume":"15","author":"Vinolo","year":"2012","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bcp.2016.03.017","article-title":"Metabolism meets immunity: The role of free fatty acid receptors in the immune system","volume":"114","author":"Milligan","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"C612","DOI":"10.1152\/ajpcell.00123.2015","article-title":"A novel anti-inflammatory role of GPR120 in intestinal epithelial cells","volume":"310","author":"Anbazhagan","year":"2016","journal-title":"Am. J. Physiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ajpath.2014.09.010","article-title":"Tumor necrosis factor \u03b1 decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in crohn disease","volume":"185","author":"Tsukahara","year":"2015","journal-title":"Am. J. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"22207","DOI":"10.1074\/jbc.M115.703835","article-title":"Branched fatty acid esters of hydroxy fatty acids (FAHFAs) protect against colitis by regulating gut innate and adaptive immune responses","volume":"291","author":"Lee","year":"2016","journal-title":"J. Biol. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"19032","DOI":"10.1038\/srep19032","article-title":"Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation","volume":"6","author":"Agus","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7514","DOI":"10.4049\/jimmunol.0900063","article-title":"G Protein-Coupled Receptor 43 Is Essential for Neutrophil Recruitment during Intestinal Inflammation","volume":"183","author":"Sina","year":"2009","journal-title":"J. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/j.gastro.2013.04.056","article-title":"Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice","volume":"145","author":"Kim","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"119549","DOI":"10.1016\/j.ijpharm.2020.119549","article-title":"Silver nanoparticles based on blackcurrant extract show potent anti-inflammatory effect in vitro and in DSS-induced colitis in mice","volume":"585","author":"Krajewska","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_19","first-page":"213","article-title":"Comparison of phenolic compounds, antioxidant and cytotoxic activity of extracts prepared from Japanese quince (Chaenomeles japonica L.) leaves","volume":"71","author":"Chojnacka","year":"2020","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.tiv.2010.04.002","article-title":"Inflammatory parameters in Caco-2 cells: Effect of stimuli nature, concentration, combination and cell differentiation","volume":"24","author":"Hendrickx","year":"2010","journal-title":"Toxicol. Vitr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.peptides.2018.08.011","article-title":"Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH 2) with anti-inflammatory activity in the mouse models of colitis","volume":"108","author":"Salaga","year":"2018","journal-title":"Peptides"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Bartoszek, A., Makaro, A., Bartoszek, A., Kordek, R., Fichna, J., and Salaga, M. (2020). Walnut Oil Alleviates Intestinal Inflammation and Restores Intestinal Barrier Function in Mice. Nutrients, 12.","DOI":"10.3390\/nu12051302"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"jcs220640","DOI":"10.1242\/jcs.220640","article-title":"CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways","volume":"131","author":"Sadej","year":"2018","journal-title":"J. Cell Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1326-e128","DOI":"10.1111\/j.1365-2982.2009.01369.x","article-title":"Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating \u03ba-opioid and cannabinoid receptors","volume":"21","author":"Fichna","year":"2009","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11894-020-00794-y","article-title":"Inflammatory Bowel Disease Environmental Risk Factors: Diet and Gut Microbiota","volume":"22","author":"Altajar","year":"2020","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.cell.2010.07.041","article-title":"GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects","volume":"142","author":"Oh","year":"2010","journal-title":"Cell"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Nijakowski, K., and Surdacka, A. (2020). Salivary Biomarkers for Diagnosis of Inflammatory Bowel Diseases: A Systematic Review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207477"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Huangfu, S., Dou, R., Zhong, S., Guo, M., Gu, C., Jurczyszyn, A., Yang, Y., and Jiang, B. (2020). Modified Pulsatillae decoction inhibits DSS-induced ulcerative colitis in vitro and in vivo via IL-6\/STAT3 pathway. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-02974-9"},{"key":"ref_29","first-page":"201","article-title":"Forskolin: A unique diterpene activator of cyclic AMP-generating systems","volume":"7","author":"Seamon","year":"1981","journal-title":"J. Cycl. Nucleotide Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1073\/pnas.94.7.3010","article-title":"cAMP-mediated inhibition of the epithelial brush border Na+\/H+ exchanger, NHE3, requires an associated regulatory protein","volume":"94","author":"Yun","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/1440-1681.12646","article-title":"Hydrogen peroxide scavenger, catalase, alleviates ion transport dysfunction in murine colitis","volume":"43","author":"Barrett","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.pa.20.040180.000311","article-title":"Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable Membranes","volume":"20","author":"Catterall","year":"1980","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cmet.2007.12.003","article-title":"Metabolomics Reveals that Hepatic Stearoyl-CoA Desaturase 1 Downregulation Exacerbates Inflammation and Acute Colitis","volume":"7","author":"Chen","year":"2008","journal-title":"Cell Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8397","DOI":"10.18632\/oncotarget.14210","article-title":"GPR120, a potential therapeutic target for experimental colitis in IL-10 deficient mice","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1572-0241.1998.229_a.x","article-title":"Distal procto-colitis, natural cytotoxicity, and essential fatty acids","volume":"93","author":"Almallah","year":"1998","journal-title":"Am. J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"7960","DOI":"10.1158\/0008-5472.CAN-10-1396","article-title":"Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis","volume":"70","author":"Woodworth","year":"2010","journal-title":"Cancer Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1476-511X-12-81","article-title":"Effects of increase in fish oil intake on intestinal eicosanoids and inflammation in a mouse model of colitis","volume":"12","author":"Bosco","year":"2013","journal-title":"Lipids Health Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/gutjnl-2018-316906","article-title":"Tight junction proteins in gastrointestinal and liver disease","volume":"68","author":"Zeisel","year":"2019","journal-title":"Gut"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1186\/1476-4598-13-167","article-title":"Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis","volume":"13","author":"Pope","year":"2014","journal-title":"Mol. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/mi.2014.21","article-title":"Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis","volume":"7","author":"Ahmad","year":"2014","journal-title":"Mucosal Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1053\/j.gastro.2011.10.025","article-title":"Inflammation and disruption of the mucosal architecture in claudin-7-deficient mice","volume":"142","author":"Ding","year":"2012","journal-title":"Gastroenterology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1097\/MIB.0000000000000550","article-title":"Pharmaceutical Activation or Genetic Absence of ClC-2 Alters Tight Junctions During Experimental Colitis","volume":"21","author":"Jin","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_43","first-page":"2153","article-title":"Somatostatin regulates tight junction proteins expression in colitis mice","volume":"7","author":"Li","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/gut.31.5.539","article-title":"Dietary fish oil reduces progression of chronic inflammatory lesions in a rat model of granulomatous colitis","volume":"31","author":"Vilaseca","year":"1990","journal-title":"Gut"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1054\/plef.1999.0111","article-title":"Is administration of n-3 fatty acids by mucosal enema protective against trinitrobenzene-induced colitis in rats?","volume":"61","author":"Yuceyar","year":"1999","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.cgh.2018.01.036","article-title":"Eicosapentaenoic Acid Reduces Fecal Levels of Calprotectin and Prevents Relapse in Patients With Ulcerative Colitis","volume":"16","author":"Scaioli","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lev-Tzion, R., Griffiths, A.M., Leder, O., and Turner, D. (2014). Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn\u2019s disease. Cochrane Database Syst. Rev., CD006320.","DOI":"10.1002\/14651858.CD006320.pub4"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Suckow, A.T., and Briscoe, C.P. (2016). Key Questions for Translation of FFA Receptors: From Pharmacology to Medicines, Springer.","DOI":"10.1007\/164_2016_45"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.yexcr.2018.05.005","article-title":"Involvement of FFA1 and FFA4 in the regulation of cellular functions during tumor progression in colon cancer cells","volume":"369","author":"Onishi","year":"2018","journal-title":"Exp. Cell Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/ijc.25638","article-title":"G-protein-coupled receptor for short-chain fatty acids suppresses colon cancer","volume":"128","author":"Tang","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1038\/onc.2013.264","article-title":"Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma","volume":"32","author":"Wu","year":"2013","journal-title":"Oncogene"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/8\/2716\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:41:59Z","timestamp":1760164919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/8\/2716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,6]]},"references-count":51,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["nu13082716"],"URL":"https:\/\/doi.org\/10.3390\/nu13082716","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,6]]}}}