{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:01:07Z","timestamp":1771948867740,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin D (VitD) may affect immune system modulation and result in the development of atopic dermatitis (AD). However, published findings have remained controversial. We investigated the association between early-life 25-hydroxyvitamin D (25(OH)D) levels and AD risk at childhood with a birth cohort. The data were obtained from \u201cthe Japan Environment and Children\u2019s Study (JECS)\u201d and \u201cthe Sub-Cohort study of JECS\u201d performed with children aged 2 years. \u201cLiquid chromatography-tandem mass spectrometry\u201d was used to measure VitD. The information on AD was obtained from parents\u2019 answers to a questionnaire when their children were aged 3 years. In order to explain the seasonal effects on VitD levels, a deseasonalized continuous variable was further calculated. The logistic regression models were fitted to evaluate the effect of VitD on childhood AD. The study included 4378 children with complete data on VitD and AD. The results from models indicated that low VitD at 2 years was not a risk factor for the development of AD at 3 years, after adjusting for potential confounders. Moreover, there was no U-shape relationship between deseasonalized VitD and childhood AD. Overall, early-life 25(OH)D levels were not link to the increased risk of developing childhood AD.<\/jats:p>","DOI":"10.3390\/nu13082761","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T02:40:14Z","timestamp":1628736014000},"page":"2761","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children\u2019s Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3936-6371","authenticated-orcid":false,"given":"Limin","family":"Yang","sequence":"first","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"},{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Research Institute for Child Health and Development, Tokyo 157-0074, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miori","family":"Sato","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"},{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Research Institute for Child Health and Development, Tokyo 157-0074, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayako","family":"Saito-Abe","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"},{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Research Institute for Child Health and Development, Tokyo 157-0074, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minaho","family":"Nishizato","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"},{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Research Institute for Child Health and Development, Tokyo 157-0074, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-164X","authenticated-orcid":false,"given":"Hidetoshi","family":"Mezawa","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"},{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Research Institute for Child Health and Development, Tokyo 157-0074, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-9620","authenticated-orcid":false,"given":"Kiwako","family":"Yamamoto-Hanada","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"},{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Research Institute for Child Health and Development, Tokyo 157-0074, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Ohya","sequence":"additional","affiliation":[{"name":"Allergy Center, National Center for Child Health and Development, Tokyo 157-8535, Japan"},{"name":"Medical Support Center for the Japan Environment and Children\u2019s Study, National Research Institute for Child Health and Development, Tokyo 157-0074, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Japan Environment and Children\u2019s Study (JECS) Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/pai.12530","article-title":"Associations of maternal and fetal 25-hydroxyvitamin D levels with childhood eczema: The Generation R Study","volume":"27","author":"Gazibara","year":"2016","journal-title":"Pediatr. 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