{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:00:42Z","timestamp":1787029242186,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T00:00:00Z","timestamp":1629331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AG19310"],"award-info":[{"award-number":["R01-AG19310"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG20116"],"award-info":[{"award-number":["R01 AG20116"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30-AG028747"],"award-info":[{"award-number":["P30-AG028747"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK072488"],"award-info":[{"award-number":["P30 DK072488"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The purpose of this study was to compare changes in bone mineral density (BMD) over a 6 month follow up (period of weight regain) in overweight, postmenopausal women having previously completed a 6 month weight loss (WL) intervention with and without aerobic exercise (AEX). Women (BMI &gt; 25 kg\/m2) underwent VO2max and DEXA scans at baseline, after 6 months of WL or AEX + WL, and at 12 months ad libitum follow up. Both groups lost ~9% body weight from 0 to 6 months and regained ~2% from 6 to 12 months, while losing ~4% of appendicular lean mass (ALM) across the 12-month study duration. VO2max increased 10% from 0 to 6 months and declined 12% from 6 to 12 months for AEX + WL, with no changes for WL. Total body (p &lt; 0.01) and total femur (p = 0.03) BMD decreased similar between groups across time (combined groups: 0\u20136 months: total body: \u22121.2% and total femur: \u22121.2%; 6\u201312 months: total body: \u22120.26% and total femur: \u22120.09%). Less ALM loss and greater VO2max increases during the WL phase were associated with attenuated BMD loss at various anatomical sites during periods of weight regain (6\u201312 months) p\u2019s &lt; 0.05). Results suggest that BMD loss may continue following WL, despite weight regain. Further, this study adds to the literature by suggesting that preventing declines in muscle quality and function during WL may attenuate the loss of BMD during weight regain. Future studies are needed to identify mechanisms underlying WL-induced bone loss so that effective practices can be designed to minimize the loss of BMD during WL and weight maintenance in older women.<\/jats:p>","DOI":"10.3390\/nu13082848","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T09:58:06Z","timestamp":1629367086000},"page":"2848","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bone Mineral Density Changes during Weight Regain following Weight Loss with and without Exercise"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-4675","authenticated-orcid":false,"given":"Monica C.","family":"Serra","sequence":"first","affiliation":[{"name":"Division of Geriatrics, Gerontology & Palliative Medicine and the Sam & Ann Barshop Institute for Longevity & Aging Studies, Department of Medicine, UT Health San Antonio, San Antonio, TX 78229, USA"},{"name":"San Antonio Geriatric Research Education and Clinical Center (GRECC), South Texas Veterans Health Care System, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice S.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Palliative Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA"},{"name":"Baltimore GRECC, VA Maryland Health Care System, Baltimore, MD 21201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,19]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention (2021, July 18). Adult Obesity Facts 2021, Available online: https:\/\/www.cdc.gov\/obesity\/data\/adult.html."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s40273-014-0243-x","article-title":"The Epidemiology of Obesity: A Big Picture","volume":"33","author":"Hruby","year":"2015","journal-title":"Pharmacoeconomics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1080\/21551197.2018.1564721","article-title":"Weight Loss-Induced Reduction of Bone Mineral Density in Older Adults with Obesity","volume":"38","author":"Jiang","year":"2019","journal-title":"J. Nutr. Gerontol. Geriatr."},{"key":"ref_4","first-page":"183","article-title":"Maintenance of Lost Weight and Long-Term Management of Obesity","volume":"102","author":"Hall","year":"2018","journal-title":"Med. Clin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/ejcn.2011.212","article-title":"Weight-loss-associated changes in bone mineral density and bone turnover after partial weight regain with or without aerobic exercise in obese women","volume":"66","author":"Hinton","year":"2012","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1038\/oby.2011.263","article-title":"A losing battle: Weight regain does not restore weight loss-induced bone loss in postmenopausal women","volume":"19","author":"Villalon","year":"2011","journal-title":"Obesity"},{"key":"ref_7","first-page":"561","article-title":"Bone loss associated with a high fibre weight reduction diet in postmenopausal women","volume":"48","author":"Avenell","year":"1994","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2337\/dc06-2537","article-title":"Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: The health, aging, and body composition study","volume":"30","author":"Park","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.exger.2013.02.005","article-title":"Weight loss in obese adults 65years and older: A review of the controversy","volume":"48","author":"Waters","year":"2013","journal-title":"Exp. Gerontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/GME.0b013e3182a76fd5","article-title":"Does bone loss begin after weight loss ends? Results 2 years after weight loss or regain in postmenopausal women","volume":"21","author":"Sukumar","year":"2014","journal-title":"Menopause"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1002\/oby.22604","article-title":"Effect of Weight Change Following Intentional Weight Loss on Bone Health in Older Adults with Obesity","volume":"27","author":"Kammire","year":"2019","journal-title":"Obesity"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bone.2008.05.012","article-title":"Meta-analysis of walking for preservation of bone mineral density in postmenopausal women","volume":"43","author":"Carroll","year":"2008","journal-title":"Bone"},{"key":"ref_13","first-page":"11","article-title":"Impact of Weight Loss and Aerobic Exercise on Nutrition and Bone Mineral Density in African American and Caucasian Postmenopausal Women","volume":"2","author":"Serra","year":"2013","journal-title":"J. Aging Res. Clin. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1152\/jappl.1998.84.4.1305","article-title":"Aerobic exercise maintains regional bone mineral density during weight loss in postmenopausal women","volume":"84","author":"Ryan","year":"1998","journal-title":"J. Appl. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1002\/jbmr.475","article-title":"Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones","volume":"26","author":"Shah","year":"2011","journal-title":"J. Bone Min. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1001\/archinte.166.22.2502","article-title":"Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: A randomized controlled trial","volume":"166","author":"Villareal","year":"2006","journal-title":"Arch. Int. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00256-011-1196-1","article-title":"Beneficial impact of aerobic exercises on bone mineral density in obese premenopausal women under caloric restriction","volume":"41","author":"Hosny","year":"2012","journal-title":"Skelet. Radiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1056\/NEJMoa1008234","article-title":"Weight loss, exercise, or both and physical function in obese older adults","volume":"364","author":"Villareal","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1210\/jc.2007-1473","article-title":"Effect of Weight Loss and Exercise Therapy on Bone Metabolism and Mass in Obese Older Adults: A One-Year Randomized Controlled Trial","volume":"93","author":"Villareal","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0002-9343(93)90253-L","article-title":"Effect of an energy-restrictive diet, with or without exercise, on lean tissue mass, resting metabolic rate, cardiovascular risk factors, and bone in overweight postmenopausal women","volume":"95","author":"Svendsen","year":"1993","journal-title":"Am. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.joca.2014.04.002","article-title":"The independent and combined effects of intensive weight loss and exercise training on bone mineral density in overweight and obese older adults with osteoarthritis","volume":"22","author":"Beavers","year":"2014","journal-title":"Osteoarthr. Cartilag."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/oby.22032","article-title":"Metabolic Benefits of Prior Weight Loss with and without Exercise on Subsequent 6-Month Weight Regain","volume":"26","author":"Ryan","year":"2018","journal-title":"Obesity"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"E145","DOI":"10.1152\/ajpendo.00618.2010","article-title":"Exercise with calorie restriction improves insulin sensitivity and glycogen synthase activity in obese postmenopausal women with impaired glucose tolerance","volume":"302","author":"Ryan","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s001980170130","article-title":"Bone mineral density during reduction, maintenance and regain of body weight in premenopausal, obese women","volume":"12","author":"Fogelholm","year":"2001","journal-title":"Osteoporos. Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1002\/jbmr.2269","article-title":"The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine","volume":"29","author":"Wright","year":"2014","journal-title":"J. Bone Min. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3803\/EnM.2016.31.4.547","article-title":"Association between Obesity and Bone Mineral Density by Gender and Menopausal Status","volume":"31","author":"Salamat","year":"2016","journal-title":"Endocrinol. Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1210\/jc.2006-0572","article-title":"Relationship of obesity with osteoporosis","volume":"92","author":"Zhao","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cariati, I., Bonanni, R., Onorato, F., Mastrogregori, A., Rossi, D., Iundusi, R., Gasbarra, E., Tancredi, V., and Tarantino, U. (2021). Role of Physical Activity in Bone-Muscle Crosstalk: Biological Aspects and Clinical Implications. J. Funct. Morphol. Kinesiol., 6.","DOI":"10.3390\/jfmk6020055"},{"key":"ref_29","unstructured":"Dempster, D.W., Cauley, J.A., Bouxsein, M.L., and Cosman, F. (2021). Chapter 35\u2014Bone, muscle, and sarcopenia. Marcus and Feldman\u2019s Osteoporosis, Academic Press. [5th ed.]."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1359\/jbmr.1998.13.7.1141","article-title":"Type of physical activity, muscle strength, and pubertal stage as determinants of bone mineral density and bone area in adolescent boys","volume":"13","author":"Nordstrom","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1172\/JCI112618","article-title":"Physical fitness is a major determinant of femoral neck and lumbar spine bone mineral density","volume":"78","author":"Pocock","year":"1986","journal-title":"J. Clin. Investig."},{"key":"ref_32","first-page":"231","article-title":"Physical fitness effect on bone mass in postmenopausal women","volume":"67","author":"Chow","year":"1986","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/jbmr.5650040318","article-title":"Relationship of body composition, muscle strength, and aerobic capacity to bone mineral density in older men and women","volume":"4","author":"Bevier","year":"1989","journal-title":"J. Bone Miner. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fendo.2020.00122","article-title":"The Interplay between Bone and Glucose Metabolism","volume":"11","author":"Cipriani","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12603-012-0421-5","article-title":"Long-term maintenance of weight loss after lifestyle intervention in frail, obese older adults","volume":"17","author":"Waters","year":"2013","journal-title":"J. Nutr. Health Aging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"536735","DOI":"10.4061\/2011\/536735","article-title":"Similarities in acquired factors related to postmenopausal osteoporosis and sarcopenia","volume":"2011","author":"Sirola","year":"2011","journal-title":"J. Osteoporos."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/GL-2020-0524SUPPL","article-title":"American Association of Clinical Endocrinologists\/American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis-2020 Update","volume":"26","author":"Camacho","year":"2020","journal-title":"Endocr. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Benedetti, M.G., Furlini, G., and Zati, A. (2018). The Effectiveness of Physical Exercise on Bone Density in Osteoporotic Patients. BioMed Res. Int., 2018.","DOI":"10.1155\/2018\/4840531"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/jbmr.3555","article-title":"Effect of Exercise Modality During Weight Loss on Bone Health in Older Adults with Obesity and Cardiovascular Disease or Metabolic Syndrome: A Randomized Controlled Trial","volume":"33","author":"Beavers","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jocd.2007.05.002","article-title":"A generalized least significant change for individuals measured on different DXA systems","volume":"10","author":"Shepherd","year":"2007","journal-title":"J. Clin. Densitom."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/8\/2848\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:47:19Z","timestamp":1760165239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/8\/2848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,19]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["nu13082848"],"URL":"https:\/\/doi.org\/10.3390\/nu13082848","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,19]]}}}