{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T08:11:24Z","timestamp":1782029484528,"version":"3.54.5"},"reference-count":58,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD097067"],"award-info":[{"award-number":["HD097067"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["2018-67001-28266"],"award-info":[{"award-number":["2018-67001-28266"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study evaluates the prevalence of autistic behaviors in fragile X syndrome as a function of infant diet. Retrospective survey data from the Fragile X Syndrome Nutrition Study, which included data on infant feeding and caregiver-reported developmental milestones for 190 children with fragile X syndrome enrolled in the Fragile X Online Registry with Accessible Database (FORWARD), were analyzed. Exploratory, sex-specific associations were found linking the use of soy-based infant formula with worse autistic behaviors related to language in females and self-injurious behavior in males. These findings prompt prospective evaluation of the effects of soy-based infant formula on disease comorbidities in fragile X syndrome, a rare disorder for which newborn screening could be implemented if there was an intervention. Gastrointestinal problems were the most common reason cited for switching to soy-based infant formula. Thus, these findings also support the study of early gastrointestinal problems in fragile X syndrome, which may underly the development and severity of disease comorbidities. In conjunction with comorbidity data from the previous analyses of the Fragile X Syndrome Nutrition Study, the findings indicate that premutation fragile X mothers should be encouraged to breastfeed.<\/jats:p>","DOI":"10.3390\/nu13082888","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T21:47:52Z","timestamp":1629668872000},"page":"2888","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Parental Reports on Early Autism Behaviors in Their Children with Fragile X Syndrome as a Function of Infant Feeding"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-3279","authenticated-orcid":false,"given":"Cara J.","family":"Westmark","sequence":"first","affiliation":[{"name":"Department of Neurology, Molecular & Environmental Toxicology Center, University of Wisconsin, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders, DSM-5, American Psychiatric Association. [5th ed.].","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6904a1","article-title":"Prevalence of Autism Spectrum Disorder among Children Aged 8 Years\u2014Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2016","volume":"69","author":"Maenner","year":"2020","journal-title":"MMWR Surveill. Summ."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chiarotti, F., and Venerosi, A. (2020). Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014. Brain Sci., 10.","DOI":"10.3390\/brainsci10050274"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.publhealth.28.021406.144007","article-title":"The Epidemiology of Autism Spectrum Disorders","volume":"28","author":"Newschaffer","year":"2007","journal-title":"Annu. Rev. Public Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"E88","DOI":"10.1542\/peds.108.5.e88","article-title":"The Influence of Environmental and Genetic Factors on Behavior Problems and Autistic Symptoms in Boys and Girls with Fragile X Syndrome","volume":"108","author":"Hessl","year":"2001","journal-title":"Pediatrics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/aur.168","article-title":"Modifying Behavioral Phenotypes in Fmr1KO Mice: Genetic Background Differences Reveal Autistic-Like Responses","volume":"4","author":"Spencer","year":"2011","journal-title":"Autism Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Masini, E., Loi, E., Vega-Benedetti, A.F., Carta, M., Doneddu, G., Fadda, R., and Zavattari, P. (2020). An Overview of the Main Genetic, Epigenetic and Environmental Factors Involved in Autism Spectrum Disorder Focusing on Synaptic Activity. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218290"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1365-2788.2012.01609.x","article-title":"Early Identification of Autism in Fragile X Syndrome: A Review","volume":"57","author":"McCary","year":"2013","journal-title":"J. Intellect. Disabil. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1007\/s10803-006-0205-z","article-title":"Autism Spectrum Phenotype in Males and Females with Fragile X Full Mutation and Premutation","volume":"37","author":"Clifford","year":"2007","journal-title":"J. Autism Dev. Disord."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S194","DOI":"10.1542\/peds.2016-1159F","article-title":"Autism Spectrum Disorder in Fragile X Syndrome: Cooccurring Conditions and Current Treatment","volume":"139","author":"Kaufmann","year":"2017","journal-title":"Pediatrics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3233\/JAD-2012-121426","article-title":"Soy-Based Diet Exacerbates Seizures in Mouse Models of Neurological Disease","volume":"33","author":"Westmark","year":"2013","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Westmark, C.J. (2014). Soy Infant Formula and Seizures in Children with Autism: A Retrospective Study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0080488"},{"key":"ref_13","first-page":"20727","article-title":"Soy Infant Formula may be Associated with Increased Autistic Behaviors","volume":"3","author":"Westmark","year":"2013","journal-title":"Autism-Open Access"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Westmark, C.J., Kniss, C., Sampene, E., Wang, A., Milunovich, A., Elver, K., Hessl, D., Talboy, A., Picker, J., and Haas-Givler, B. (2020). Soy-Based Infant Formula is Associated with an Increased Prevalence of Comorbidities in Fragile X Syndrome. Nutrients, 12.","DOI":"10.3390\/nu12103136"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Westmark, C.J. (2021). Consumption of Breast Milk is Associated with Decreased Prevalence of Autism in Fragile X Syndrome. Nutrients, 13.","DOI":"10.3390\/nu13061785"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fneur.2014.00169","article-title":"A Hypothesis regarding the Molecular Mechanism Underlying Dietary Soy-Induced Effects on Seizure Propensity","volume":"5","author":"Westmark","year":"2014","journal-title":"Front. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnut.2016.00059","article-title":"Soy-Based Therapeutic Baby Formulas: Testable Hypotheses regarding the Pros and Cons","volume":"3","author":"Westmark","year":"2017","journal-title":"Front. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S183","DOI":"10.1542\/peds.2016-1159E","article-title":"FORWARD: A Registry and Longitudinal Clinical Database to Study Fragile X Syndrome","volume":"139","author":"Sherman","year":"2017","journal-title":"Pediatrics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000509797","article-title":"Prenatal High-Fat Diet Rescues Communication Deficits in Fmr1 Mutant Mice in a Sex-Specific Manner","volume":"42","author":"Nolan","year":"2020","journal-title":"Dev. Neurosci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Schiavi, S., Carbone, E., Melancia, F., Buzzelli, V., Manduca, A., Campolongo, P., Pallottini, V., and Trezza, V. (2020). Perinatal Supplementation with Omega-3 Fatty Acids Corrects the Aberrant Social and Cognitive Traits Observed in a Genetic Model of Autism Based on FMR1 Deletion in Rats. Nutr. Neurosci., 1\u201314.","DOI":"10.1080\/1028415X.2020.1819107"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"104687","DOI":"10.1016\/j.neuint.2020.104687","article-title":"Preclinical Testing of the Ketogenic Diet in Fragile X Mice","volume":"134","author":"Westmark","year":"2020","journal-title":"Neurochem. Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.psyneuen.2014.07.002","article-title":"Dietary Supplementation of Omega-3 Fatty Acids Rescues Fragile X Phenotypes in Fmr1-Ko Mice","volume":"49","author":"Pietropaolo","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neubiorev.2014.04.007","article-title":"One-Carbon Metabolism in Neurodevelopmental Disorders: Using Broad-Based Nutraceutics to Treat Cognitive Deficits in Complex Spectrum Disorders","volume":"46 Pt 2","author":"Schaevitz","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Barnhill, K., Devlin, M., Moreno, H.T., Potts, A., Richardson, W., Schutte, C., and Hewitson, L. (2018). Brief Report: Implementation of a Specific Carbohydrate Diet for a Child with Autism Spectrum Disorder and Fragile X Syndrome. J. Autism Dev. Disord.","DOI":"10.1007\/s10803-018-3704-9"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1044\/2018_JSLHR-L-18-0008","article-title":"A Multimethod Analysis of Pragmatic Skills in Children and Adolescents with Fragile X Syndrome, Autism Spectrum Disorder, and Down Syndrome","volume":"61","author":"Martin","year":"2018","journal-title":"J. Speech Lang. Hear. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1044\/2016_JSLHR-L-15-0360","article-title":"Growth of Expressive Syntax in Children with Fragile X Syndrome","volume":"60","author":"Komesidou","year":"2017","journal-title":"J. Speech Lang. Hear. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ridd.2018.04.024","article-title":"A Comparison of Functional Academic and Daily Living Skills in Males with Fragile X Syndrome with and without Autism","volume":"78","author":"Raspa","year":"2018","journal-title":"Res. Dev. Disabil."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1005412111706","article-title":"Early Development, Temperament, and Functional Impairment in Autism and Fragile X Syndrome","volume":"30","author":"Bailey","year":"2000","journal-title":"J. Autism Dev. Disord."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ajmg.a.30229","article-title":"Autism Spectrum Disorder in Fragile X Syndrome: Communication, Social Interaction, and Specific Behaviors","volume":"129A","author":"Kaufmann","year":"2004","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1352\/1944-7558-122.5.359","article-title":"Differential Relationships of Anxiety and Autism Symptoms on Social Skills in Young Boys with Fragile X Syndrome","volume":"122","author":"Reisinger","year":"2017","journal-title":"Am. J. Intellect. Dev. Disabil."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2788.2006.00803.x","article-title":"Cognitive, Language and Social-Cognitive Skills of Individuals with Fragile X Syndrome with and without Autism","volume":"50","author":"Lewis","year":"2006","journal-title":"J. Intellect. Disabil. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1352\/1944-7558-117.1.1","article-title":"Behavioral Phenotype of Fragile X Syndrome in Adolescence and Adulthood","volume":"117","author":"Smith","year":"2012","journal-title":"Am. J. Intellect. Dev. Disabil."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/ajmg.a.31405","article-title":"Autism Spectrum Disorder in Fragile X Syndrome: Differential Contribution of Adaptive Socialization and Social Withdrawal","volume":"140A","author":"Budimirovic","year":"2006","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ajmg.a.20218","article-title":"Social Behavior Profile in Young Males with Fragile X Syndrome: Characteristics and Specificity","volume":"126A","author":"Kau","year":"2004","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1365-2788.2010.01315.x","article-title":"Distinguishing Features of Autism in Boys with Fragile X Syndrome","volume":"54","author":"Brock","year":"2010","journal-title":"J. Intellect. Disabil. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ridd.2018.02.020","article-title":"How Common are Challenging Behaviours Amongst Individuals with Fragile X Syndrome? A Systematic Review","volume":"76","author":"Hardiman","year":"2018","journal-title":"Res. Dev. Disabil."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1352\/1944-7558-115.6.473","article-title":"Self-Injurious Behavior and Fragile X Syndrome: Findings from the National Fragile X Survey","volume":"115","author":"Symons","year":"2010","journal-title":"Am. J. Intellect. Dev. Disabil."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s11689-020-09313-6","article-title":"Expressive Language Sampling as a Source of Outcome Measures for Treatment Studies in Fragile X Syndrome: Feasibility, Practice Effects, Test-Retest Reliability, and Construct Validity","volume":"12","author":"Abbeduto","year":"2020","journal-title":"J. Neurodev Disord."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Shaffer, R.C., Schmitt, L., John Thurman, A., Abbeduto, L., Hong, M., Pedapati, E., Dominick, K., Sweeney, J., and Erickson, C. (2020). The Relationship between Expressive Language Sampling and Clinical Measures in Fragile X Syndrome and Typical Development. Brain Sci., 10.","DOI":"10.3390\/brainsci10020066"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ridd.2018.04.004","article-title":"Response to Name and its Value for the Early Detection of Developmental Disorders: Insights from Autism Spectrum Disorder, Rett Syndrome, and Fragile X Syndrome. A Perspectives Paper","volume":"82","author":"Zhang","year":"2018","journal-title":"Res. Dev. Disabil."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s41252-017-0051-3","article-title":"Early Vocal Development in Autism Spectrum Disorder, Rett Syndrome, and Fragile X Syndrome: Insights from Studies using Retrospective Video Analysis","volume":"2","author":"Roche","year":"2018","journal-title":"Adv. Neurodev Disord."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Reisinger, D.L., Shaffer, R.C., Pedapati, E.V., Dominick, K.C., and Erickson, C.A. (2019). A Pilot Quantitative Evaluation of Early Life Language Development in Fragile X Syndrome. Brain Sci., 9.","DOI":"10.3390\/brainsci9020027"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1352\/0895-8017(2004)109<208:LACFAA>2.0.CO;2","article-title":"Linguistic and Cognitive Functioning and Autism Symptoms in Young Children with Fragile X Syndrome","volume":"109","author":"Philofsky","year":"2004","journal-title":"Am. J. Ment. Retard."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"103912","DOI":"10.1016\/j.ridd.2021.103912","article-title":"Fragile X Syndrome in Young Females: Influence of Executive Function on the Neurocognitive Profile and Adaptive Behavior","volume":"112","author":"Jacas","year":"2021","journal-title":"Res. Dev. Disabil."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kraan, C.M., Baker, E.K., Arpone, M., Bui, M., Ling, L., Gamage, D., Bretherton, L., Rogers, C., Field, M.J., and Wotton, T.L. (2020). DNA Methylation at Birth Predicts Intellectual Functioning and Autism Features in Children with Fragile X Syndrome. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207735"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/1096-8628(200023)97:3<195::AID-AJMG1037>3.0.CO;2-R","article-title":"Transcription of the FMR1 Gene in Individuals with Fragile X Syndrome","volume":"97","author":"Tassone","year":"2000","journal-title":"Am. J. Med. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/jmg.38.7.453","article-title":"A Majority of Fragile X Males with Methylated, Full Mutation Alleles have Significant Levels of FMR1 Messenger RNA","volume":"38","author":"Tassone","year":"2001","journal-title":"J. Med. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Stoger, R., Genereux, D.P., Hagerman, R.J., Hagerman, P.J., Tassone, F., and Laird, C.D. (2011). Testing the FMR1 Promoter for Mosaicism in DNA Methylation among CpG Sites, Strands, and Cells in FMR1-Expressing Males with Fragile X Syndrome. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023648"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13229-019-0271-7","article-title":"Incomplete Silencing of Full Mutation Alleles in Males with Fragile X Syndrome is Associated with Autistic Features","volume":"10","author":"Baker","year":"2019","journal-title":"Mol. Autism"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"11701","DOI":"10.1038\/s41598-020-68465-6","article-title":"FMR1 mRNA from Full Mutation Alleles is Associated with ABC-CFX Scores in Males with Fragile X Syndrome","volume":"10","author":"Baker","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s11689-019-9288-7","article-title":"Intellectual Functioning and Behavioural Features Associated with Mosaicism in Fragile X Syndrome","volume":"11","author":"Baker","year":"2019","journal-title":"J. Neurodev Disord."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/19440049.2017.1419286","article-title":"Occurrence of Glyphosate and AMPA Residues in Soy-Based Infant Formulas Sold in Brazil","volume":"35","author":"Rodrigues","year":"2018","journal-title":"Food Addit. Contam. Part A"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijdevneu.2018.10.002","article-title":"Increased Severity of Fragile X Spectrum Disorders in the Agricultural Community of Ricaurte, Colombia","volume":"72","author":"Saldarriaga","year":"2019","journal-title":"Int. J. Dev. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Okoniewski, K.C., Wheeler, A.C., Lee, S., Boyea, B., Raspa, M., Taylor, J.L., and Bailey, D.B. (2019). Early Identification of Fragile X Syndrome through Expanded Newborn Screening. Brain Sci., 9.","DOI":"10.3390\/brainsci9010004"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1542\/peds.2008-2992","article-title":"No Change in the Age of Diagnosis for Fragile x Syndrome: Findings from a National Parent Survey","volume":"124","author":"Bailey","year":"2009","journal-title":"Pediatrics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"S216","DOI":"10.1542\/peds.2016-1159H","article-title":"Fragile X Newborn Screening: Lessons Learned from a Multisite Screening Study","volume":"139","author":"Bailey","year":"2017","journal-title":"Pediatrics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s40474-014-0033-3","article-title":"Autism: A Global Perspective","volume":"2","author":"Hahler","year":"2015","journal-title":"Curr. Dev. Disord. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/MPG.0000000000000907","article-title":"Breast Milk Protects Against Gastrointestinal Symptoms in Infants at High Risk for Autism During Early Development","volume":"62","author":"Penn","year":"2016","journal-title":"J. Pediatr. Gastroenterol. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/8\/2888\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:49:14Z","timestamp":1760165354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/8\/2888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,22]]},"references-count":58,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["nu13082888"],"URL":"https:\/\/doi.org\/10.3390\/nu13082888","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,22]]}}}