{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:26:30Z","timestamp":1791905190301,"version":"4.3.4"},"reference-count":74,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"XinZhou","award":["(Qiankehe Talents (2018) 5769-27)"],"award-info":[{"award-number":["(Qiankehe Talents (2018) 5769-27)"]}]},{"name":"XinZhou","award":["Qiankehe Talents (2015) 4033"],"award-info":[{"award-number":["Qiankehe Talents (2015) 4033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Lead is one of the most common heavy metal pollutants in the environment. Prolonged exposure to lead will induce oxidative stress, inflammation, and apoptosis in the kidneys, which in turn causes kidney injury. Lycium barbarum polysaccharide (LBP) is well known for its numerous pharmacological properties. This study aims to explore the efficacy and mechanism of LBP against lead-induced kidney damage in mice. Symptoms of renal injury were induced in mice by using 25 mg\/kg lead acetate (PbAc2), and different doses of LBP (200, 400, and 600 mg\/kg BW) were orally administrated to PbAc2-treated mice for five weeks. The results of the pharmacodynamics experiment showed that the renal pathological damages, serum creatinine (Cre), blood urea nitrogen (BUN), and kidney index of PbAc2-treated mice could be significantly alleviated by treatment with LBP. Further, LBP treatment significantly increased the weight and feed intake of PbAc2-treated mice. The dose effect results indicated that a medium dose of LBP was superior to high and low doses. The results of mechanistic experiments showed that LBP could attenuate oxidative stress, inflammation, and apoptosis in the kidneys of mice with lead toxicity by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway.<\/jats:p>","DOI":"10.3390\/nu13092945","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T23:25:50Z","timestamp":1629933950000},"page":"2945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Study on the Efficacy and Mechanism of Lycium barbarum Polysaccharide against Lead-Induced Renal Injury in Mice"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-1376","authenticated-orcid":false,"given":"Wen","family":"Xie","sequence":"first","affiliation":[{"name":"Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, China"},{"name":"Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, 116 Baoshan North Rd., Guiyang 550001, China"},{"name":"The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, China"},{"name":"Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, 116 Baoshan North Rd., Guiyang 550001, China"},{"name":"The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Guo","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, China"},{"name":"Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, 116 Baoshan North Rd., Guiyang 550001, China"},{"name":"The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9946-5806","authenticated-orcid":false,"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, China"},{"name":"Guizhou Engineering Laboratory for Quality Control & Evaluation Technology of Medicine, 116 Baoshan North Rd., Guiyang 550001, China"},{"name":"The Research Center for Quality Control of Natural Medicine, Guizhou Normal University, 116 Baoshan North Rd., Guiyang 550001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ijsrc.2020.10.005","article-title":"A grain-size correction for metal pollution indexes in river sediments","volume":"36","author":"Gloaguen","year":"2020","journal-title":"Int. J. Sediment Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.envint.2019.04.046","article-title":"Pollution characteristics, sources, and health risk assessment of human exposure to Cu, Zn, Cd and Pb pollution in urban street dust across China between 2009 and 2018","volume":"128","author":"Hou","year":"2019","journal-title":"Environ. Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.envint.2019.05.025","article-title":"Status of lead accumulation in agricultural soils across China (1979\u20132016)","volume":"129","author":"Shi","year":"2019","journal-title":"Environ. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jhazmat.2011.07.097","article-title":"The protective effect of flaxseed oil on lead acetate-induced renal toxicity in rats","volume":"194","author":"Dkhil","year":"2011","journal-title":"J. Hazard. Mater."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"111251","DOI":"10.1016\/j.jinorgbio.2020.111251","article-title":"Harnessing Peptides against lead pollution and poisoning: Achievements and prospects","volume":"212","author":"Sauser","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1007\/s11033-020-05346-1","article-title":"Luteolin protects against lead acetate-induced nephrotoxicity through antioxidant, anti-inflammatory, anti-apoptotic, and Nrf2\/HO-1 signaling pathways","volume":"47","author":"Albarakati","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12011-016-0731-2","article-title":"The protective effect of baicalin against lead-induced renal oxidative damage in mice","volume":"175","author":"Zhang","year":"2017","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s43440-020-00072-8","article-title":"Role of some natural anti-oxidants in the down regulation of Kim, VCAM1, Cystatin C protein expression in lead acetate-induced acute kidney injury","volume":"72","author":"Alhusaini","year":"2020","journal-title":"Pharmacol. Rep. PR"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"126443","DOI":"10.1016\/j.jtemb.2019.126443","article-title":"Lead-induced oxidative damage in rats\/mice: A meta-analysis","volume":"58","author":"Fan","year":"2020","journal-title":"J. Trace Elem. Med. Biol. Organ Soc. Miner. Trace Elem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1007\/s11356-017-0702-y","article-title":"Preventive use of berberine in inhibition of lead-induced renal injury in rats","volume":"25","author":"Hasanein","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s12011-016-0701-8","article-title":"Alleviation of lead-induced apoptosis by puerarin via inhibiting mitochondrial permeability transition pore opening in primary cultures of rat proximal tubular cells","volume":"174","author":"Wang","year":"2016","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00204-015-1547-0","article-title":"Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead","volume":"90","author":"Liu","year":"2016","journal-title":"Arch. Toxicol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"18032","DOI":"10.1007\/s11356-019-05104-2","article-title":"Natural antidotes and management of metal toxicity","volume":"26","author":"Amadi","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.3390\/ijerph7072745","article-title":"Chelation in metal intoxication","volume":"7","author":"Flora","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3109\/15563650903321064","article-title":"A comparison of sodium calcium edetate (edetate calcium disodium) and succimer (DMSA) in the treatment of inorganic lead poisoning","volume":"47","author":"Bradberry","year":"2009","journal-title":"Clin. Toxicol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22736","DOI":"10.1007\/s11356-019-05562-8","article-title":"The remedial effect of Thymus vulgaris extract against lead toxicity-induced oxidative stress, hepatorenal damage, immunosuppression, and hematological disorders in rats","volume":"26","author":"Refaat","year":"2019","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/tox.22634","article-title":"Potential immunomodulatory and antioxidant effects of walnut Juglans regia vegetable oil against lead-mediated hepatic damage and their interaction with lipase activity in rats","volume":"33","author":"Soussi","year":"2018","journal-title":"Environ. Toxicol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12372","DOI":"10.1007\/s11356-017-8876-x","article-title":"Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats","volume":"24","author":"Ashshi","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jep.2017.10.010","article-title":"The genus Lycium as food and medicine: A botanical, ethnobotanical and historical review","volume":"212","author":"Yao","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2305683","DOI":"10.1155\/2018\/2305683","article-title":"Lycium barbarum polysaccharide promotes maturation of dendritic cell via notch signaling and strengthens dendritic cell mediated t lymphocyte cytotoxicity on colon cancer cell CT26-WT","volume":"2018","author":"Wang","year":"2018","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1262\/jrd.2018-104","article-title":"Lycium barbarum polysaccharide enhances development of previously-cryopreserved murine two-cell embryos via restoration of mitochondrial function and down-regulated generation of reactive oxygen species","volume":"65","author":"Yang","year":"2019","journal-title":"J. Reprod. Dev."},{"key":"ref_22","first-page":"6379493","article-title":"Effects of Lycium barbarum polysaccharides on health and aging of C. elegans depend on daf-12\/daf-16","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.12659\/MSM.913820","article-title":"The effects of Lycium Barbarum polysaccharide (LBP) in a mouse model of cerulein-induced acute pancreatitis","volume":"25","author":"Xiong","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2174\/1573406410666141110153858","article-title":"Practical Application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes","volume":"11","author":"Cai","year":"2015","journal-title":"Med. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.lfs.2004.04.056","article-title":"Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum","volume":"76","author":"Luo","year":"2004","journal-title":"Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.ijbiomac.2019.09.177","article-title":"Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP\/PS1 transgenic mice","volume":"144","author":"Zhou","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.2147\/DDDT.S176316","article-title":"Lycium barbarum polysaccharide prevents cisplatin-induced MLTC-1 cell apoptosis and autophagy via regulating endoplasmic reticulum stress pathway","volume":"12","author":"Yang","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1167\/iovs.19-27886","article-title":"Posttreatment intervention with Lycium Barbarum polysaccharides is neuroprotective in a rat model of chronic ocular hypertension","volume":"60","author":"Lakshmanan","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1039\/C9FO00638A","article-title":"Modulating effects of polysaccharides from the fruits of Lycium barbarum on the immune response and gut microbiota in cyclophosphamide-treated mice","volume":"10","author":"Ding","year":"2019","journal-title":"Food Funct."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e20190010000003","DOI":"10.1590\/s0102-865020190010000003","article-title":"LBP reduces the inflammatory injury of kidney in septic rat and regulates the Keap1-Nrf2\/ARE signaling pathway1","volume":"34","author":"Huang","year":"2019","journal-title":"Acta Cir. Bras."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s12011-015-0360-1","article-title":"Curcumin ameliorates lead (Pb(2+))-induced hemato-biochemical alterations and renal oxidative damage in a rat model","volume":"168","author":"Ali","year":"2015","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Worley, B., Halouska, S., and Powers, R. (2012). Utilities for quantifying separation in PCA\/PLS-DA scores plots. Anal. Biochem., 433.","DOI":"10.1016\/j.ab.2012.10.011"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2221-1691(11)60187-1","article-title":"Effect of lead acetate toxicity on experimental male albino rat","volume":"2","author":"Ibrahim","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"435857","DOI":"10.1155\/2014\/435857","article-title":"Protective role of omega-3 polyunsaturated fatty acid against lead acetate-induced toxicity in liver and kidney of female rats","volume":"2014","author":"Abdou","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"556248","DOI":"10.3389\/fphar.2020.556248","article-title":"Protective effects of smilax glabra Roxb. against lead-induced renal oxidative stress, inflammation and apoptosis in weaning rats and HEK-293 cells","volume":"11","author":"Shi","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_36","first-page":"125","article-title":"Age-related effects of lead poisoning on some haematological parameters in adult wistar rats","volume":"34","author":"Daku","year":"2019","journal-title":"Niger. J. Physiol. Sci. Off. Publ. Physiol. Soc. Niger."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.aquatox.2019.02.013","article-title":"Immune response, MT and HSP70 gene expression, and bioaccumulation induced by lead exposure of the marine crab, Charybdis japonica","volume":"210","author":"Xu","year":"2019","journal-title":"Aquat. Toxicol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"109591","DOI":"10.1016\/j.biopha.2019.109591","article-title":"Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide","volume":"121","author":"Zhu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/jpn.13247","article-title":"Effects of dietary supplementation of Lycium barbarum polysaccharides on growth performance, immune status, antioxidant capacity and selected microbial populations of weaned piglets","volume":"104","author":"Chen","year":"2020","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_40","first-page":"13","article-title":"Comparative oxidative stress, metallothionein induction and organ toxicity following chronic exposure to arsenic, lead and mercury in rats","volume":"60","author":"Agrawal","year":"2014","journal-title":"Cell. Mol. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"33723","DOI":"10.1007\/s11356-020-09643-x","article-title":"Alleviation of lead acetate-induced nephrotoxicity by Moringa oleifera extract in rats: Highlighting the antioxidant, anti-inflammatory, and anti-apoptotic activities","volume":"27","author":"Alkahtani","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijbiomac.2014.05.034","article-title":"Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway","volume":"69","author":"Xiao","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_43","unstructured":"Walker, H.K., Hall, W.D., and Hurst, J.W. (1990). BUN and Creatinine. Clinical Methods: The History, Physical, and Laboratory Examinations, Butterworths."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1139\/Y09-068","article-title":"Protective effect of Lycium barbarum polysaccharide 4 on kidneys in streptozotocin-induced diabetic rats","volume":"87","author":"Zhao","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3140290","DOI":"10.1155\/2016\/3140290","article-title":"Lycium barbarum polysaccharide mediated the antidiabetic and antinephritic effects in diet-streptozotocin-induced diabetic Sprague Dawley rats via regulation of NF-\u03baB","volume":"2016","author":"Du","year":"2016","journal-title":"BioMed Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1080\/13880209.2020.1817951","article-title":"Lycium barbarum polysaccharides protect mice from hyperuricaemia through promoting kidney excretion of uric acid and inhibiting liver xanthine oxidase","volume":"58","author":"Yu","year":"2020","journal-title":"Pharm. Biol."},{"key":"ref_47","first-page":"7","article-title":"Protective effect of Lycium barbarum polysaccharides against high-fat diet-induced renal injury and lipid deposition in rat kidneys","volume":"33","author":"Liao","year":"2019","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"8244","DOI":"10.1007\/s11356-016-6333-x","article-title":"A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment","volume":"23","author":"Wu","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2174\/1568026013394831","article-title":"Toxic metals and oxidative stress part I: Mechanisms involved in metal-induced oxidative damage","volume":"1","author":"Ercal","year":"2001","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_50","first-page":"114","article-title":"Lead toxicity part II: The role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity","volume":"11","author":"Patrick","year":"2006","journal-title":"Altern. Med. Rev. J. Clin. Ther."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1002\/tox.21994","article-title":"Lack of reversal of oxidative damage in renal tissues of lead acetate-treated rats","volume":"30","author":"Oyagbemi","year":"2015","journal-title":"Environ. Toxicol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.etap.2010.07.002","article-title":"Quercetin protects the rat kidney against oxidative stress-mediated DNA damage and apoptosis induced by lead","volume":"30","author":"Liu","year":"2010","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.fct.2010.01.002","article-title":"The effect of oral administration of Allium sativum extracts on lead nitrate induced toxicity in male mice","volume":"48","author":"Sharma","year":"2010","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_54","first-page":"193","article-title":"Lead exposure and oxidative stress: A systematic review","volume":"236","author":"Lopes","year":"2016","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"ref_55","first-page":"26","article-title":"Abrogation by Trifolium alexandrinum root extract on hepatotoxicity induced by acetaminophen in rats","volume":"19","author":"Sakeran","year":"2014","journal-title":"Redox Rep. Commun. Free Radic. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2946","DOI":"10.1007\/s11356-016-8050-x","article-title":"Possible antioxidant effect of Lycium barbarum polysaccharides on hepatic cadmium-induced oxidative stress in rats","volume":"24","author":"Varoni","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_57","first-page":"55","article-title":"The protective effects of lycium barbarum polysaccharides on retinal neurons in diabetic rats and its mechanism","volume":"35","author":"Pan","year":"2019","journal-title":"Chin. J. Appl. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1007\/s11356-019-07009-6","article-title":"Red beetroot extract mitigates chlorpyrifos-induced reprotoxicity associated with oxidative stress, inflammation, and apoptosis in rats","volume":"27","author":"Albasher","year":"2020","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"116634","DOI":"10.1016\/j.lfs.2019.116634","article-title":"Oleuropein suppresses oxidative, inflammatory, and apoptotic responses following glycerol-induced acute kidney injury in rats","volume":"232","author":"Yin","year":"2019","journal-title":"Life Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/biof.1521","article-title":"Combination of metformin and luteolin synergistically protects carbon tetrachloride-induced hepatotoxicity: Mechanism involves antioxidant, anti-inflammatory, antiapoptotic, and Nrf2\/HO-1 signaling pathway","volume":"45","author":"Yan","year":"2019","journal-title":"BioFactors"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-1661-0_1","article-title":"Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis","volume":"1219","author":"Choudhary","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Metryka, E., Chibowska, K., Gutowska, I., Falkowska, A., Kupnicka, P., Barczak, K., Chlubek, D., and Baranowska-Bosiacka, I. (2018). Lead (Pb) exposure enhances expression of factors associated with inflammation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061813"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.bbrc.2017.11.165","article-title":"Lycium barbarum polysaccharide protects against oxygen glucose deprivation\/reoxygenation-induced apoptosis and autophagic cell death via the PI3K\/Akt\/mTOR signaling pathway in primary cultured hippocampal neurons","volume":"495","author":"Yu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jep.2014.04.013","article-title":"The effect of Lycium barbarum polysaccharides on the male rats\u2019 reproductive system and spermatogenic cell apoptosis exposed to low-dose ionizing irradiation","volume":"154","author":"Luo","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"637","DOI":"10.14336\/AD.2018.0513","article-title":"The anti-inflammatory and anti-oxidant mechanisms of the keap1\/Nrf2\/ARE signaling pathway in chronic diseases","volume":"10","author":"Tu","year":"2019","journal-title":"Aging Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Liu, C.M., Tian, Z.K., Zhang, Y.J., Ming, Q.L., Ma, J.Q., and Ji, L.P. (2020). Effects of gastrodin against lead-induced brain injury in mice associated with the Wnt\/Nrf2 pathway. Nutrients, 12.","DOI":"10.3390\/nu12061805"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"42226","DOI":"10.18632\/oncotarget.15033","article-title":"GSPE reduces lead-induced oxidative stress by activating the Nrf2 pathway and suppressing miR153 and GSK-3\u03b2 in rat kidney","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"ref_69","first-page":"579","article-title":"A review on heme oxygenase-1 induction: Is it a necessary evil","volume":"67","author":"Waza","year":"2018","journal-title":"Inflamm. Res. Off. J. Eur. Histamine Res. Soc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.bbagen.2012.06.011","article-title":"Protective role of quercetin against lead-induced inflammatory response in rat kidney through the ROS-mediated MAPKs and NF-\u03baB pathway","volume":"1820","author":"Liu","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional regulation by Nrf2","volume":"29","author":"Tonelli","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_72","first-page":"49","article-title":"Effects of different doses of hydrocortisone on the disorder of coagulation in rats at early stage of septic shock","volume":"44","author":"Wang","year":"2006","journal-title":"Chin. J. Pediatr."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.biopha.2018.12.073","article-title":"Lycium barbarum polysaccharide reduces hyperoxic acute lung injury in mice through Nrf2 pathway","volume":"111","author":"Zheng","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5968","DOI":"10.1021\/acs.jafc.9b01489","article-title":"Destiny of Dendrobium officinale polysaccharide after oral administration: Indigestible and nonabsorbing, ends in modulating gut microbiota","volume":"67","author":"Li","year":"2019","journal-title":"J. Agric. Food Chem."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/9\/2945\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:51:26Z","timestamp":1760165486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/9\/2945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,25]]},"references-count":74,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["nu13092945"],"URL":"https:\/\/doi.org\/10.3390\/nu13092945","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,25]]}}}