{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:19:13Z","timestamp":1760235553487,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/0089"],"award-info":[{"award-number":["PI18\/0089"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>(1) Background: Although a meta-analysis reported that the sensitivity of CD3+ TCR\u03b3\u03b4+ cells for coeliac disease diagnosis was &gt;93%, a recent study has suggested that sensitivity decreased to 65% in elderly patients. (2) Aim: To evaluate whether the sensitivity of intraepithelial lymphocyte cytometric patterns for coeliac disease diagnosis changes with advanced age. (3) Methods: We performed a multicentre study including 127 coeliac disease patients \u2265 50 years: 87 with baseline cytometry (45 aged 50\u201359 years; 23 aged 60\u201369 years; 19 aged \u2265 70 years), 16 also with a follow-up cytometry (on a gluten-free diet); and 40 with only follow-up cytometry. (4) Results: In Marsh 3 patients, a sensitivity of 94.7%, 88.9% and 86.7% was observed for each age group using a cut-off value of TCR\u03b3\u03b4+ &gt;10% (p = 0.27); and a sensitivity of 84.2%, 83.4% and 53.3% for a cut-off value &gt;14% (p = 0.02; 50\u201369 vs. \u226570 years), with difference between applying a cut-off of 10% or 14% (p = 0.008). The TCR\u03b3\u03b4+ count in the \u226570 years group was lower than in the other groups (p = 0.014). (5) Conclusion: In coeliac patients \u2265 70 years, the TCR\u03b3\u03b4+ count decreases and the cut-off point of &gt;10% is more accurate than &gt;14%.<\/jats:p>","DOI":"10.3390\/nu13092984","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T04:07:28Z","timestamp":1630382848000},"page":"2984","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Coeliac Disease in Elderly Patients: Value of Coeliac Lymphogram for Diagnosis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1489-504X","authenticated-orcid":false,"given":"Fernando","family":"Fern\u00e1ndez-Ba\u00f1ares","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitari Mutua Terrassa, 08221 Terrassa, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Farrais","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Planella","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefa","family":"Melero","sequence":"additional","affiliation":[{"name":"Department Immunology and Genetics, Hospital Universitario de Badajoz, 06080 Badajoz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"L\u00f3pez-Palacios","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Cl\u00ednico San Carlos, IdISSC, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Vivas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Complejo Asistencial Universitario de Le\u00f3n, 24071 Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Fern\u00e1ndez-Salazar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Cl\u00ednico Universitario de Valladolid, Gerencia Regional de Salud (SACYL), Facultad de Medicina, Universidad de Valladolid, 47002 Valladolid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Pilar","family":"Lanzarote","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Ruiz-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital Universitari Mutua Terrassa, 08221 Terrassa, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Aguilar-Criado","sequence":"additional","affiliation":[{"name":"Department Immunology and Genetics, Hospital Universitario de Badajoz, 06080 Badajoz, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of Flow Cytometry, CATLAB, 08232 Viladecavalls, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aureli","family":"Esquerda","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Serrano","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Hospital Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9489-1603","authenticated-orcid":false,"given":"Concepci\u00f3n","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Gen\u00e9tica de Enfermedades Complejas, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1177\/2050640619844125","article-title":"European Society for the Study of Coeliac Disease 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