{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:06:56Z","timestamp":1778692016928,"version":"3.51.4"},"reference-count":66,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CB2014-24162"],"award-info":[{"award-number":["CB2014-24162"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007686","name":"Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes","doi-asserted-by":"publisher","award":["3210-21205-01-14"],"award-info":[{"award-number":["3210-21205-01-14"]}],"id":[{"id":"10.13039\/501100007686","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Urinary tract infections (UTI) during pregnancy are frequently associated with hypertensive disorders, increasing the risk of perinatal morbidity. Calcitriol, vitamin D3\u2019s most active metabolite, has been involved in blood pressure regulation and prevention of UTIs, partially through modulating vasoactive peptides and antimicrobial peptides, like cathelicidin. However, nothing is known regarding the interplay between placental calcitriol, cathelicidin, and maternal blood pressure in UTI-complicated pregnancies. Here, we analyzed the correlation between these parameters in pregnant women with UTI and with normal pregnancy (NP). Umbilical venous serum calcitriol and its precursor calcidiol were significantly elevated in UTI. Regardless of newborn\u2019s sex, we found strong negative correlations between calcitriol and maternal systolic and diastolic blood pressure in the UTI cohort (p &lt; 0.002). In NP, this relationship was observed only in female-carrying mothers. UTI-female placentas showed higher expression of cathelicidin and CYP27B1, the calcitriol activating-enzyme, compared to male and NP samples. Accordingly, cord-serum calcitriol from UTI-female neonates negatively correlated with maternal bacteriuria. Cathelicidin gene expression positively correlated with gestational age in UTI and with newborn anthropometric parameters. Our results suggest that vitamin D deficiency might predispose to maternal cardiovascular risk and perinatal infections especially in male-carrying pregnancies, probably due to lower placental CYP27B1 and cathelicidin expression.<\/jats:p>","DOI":"10.3390\/nu13093114","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T13:18:26Z","timestamp":1630934306000},"page":"3114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cord Serum Calcitriol Inversely Correlates with Maternal Blood Pressure in Urinary Tract Infection-Affected Pregnancies: Sex-Dependent Immune Implications"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5456-9695","authenticated-orcid":false,"given":"Andrea","family":"Olmos-Ortiz","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n \u201cDr. Carlos Gual Castro\u201d, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga No. 15, Belisario Dom\u00ednguez Secci\u00f3n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico"},{"name":"Departamento de Inmunobioqu\u00edmica, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Montes Urales 800, Lomas-Virreyes, Lomas de Chapultepec IV Secci\u00f3n, Miguel Hidalgo, Ciudad de Mexico 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Olivares-Huerta","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n \u201cDr. Carlos Gual Castro\u201d, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga No. 15, Belisario Dom\u00ednguez Secci\u00f3n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3311-2258","authenticated-orcid":false,"given":"Janice","family":"Garc\u00eda-Quiroz","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n \u201cDr. Carlos Gual Castro\u201d, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga No. 15, Belisario Dom\u00ednguez Secci\u00f3n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-5093","authenticated-orcid":false,"given":"Euclides","family":"Avila","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n \u201cDr. Carlos Gual Castro\u201d, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga No. 15, Belisario Dom\u00ednguez Secci\u00f3n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Halhali","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n \u201cDr. Carlos Gual Castro\u201d, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga No. 15, Belisario Dom\u00ednguez Secci\u00f3n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Braulio","family":"Quesada-Reyna","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Obstetricia, UMAE Hospital de Gineco-Obstetricia No. 4 \u201cLuis Castelazo Ayala\u201d, IMSS, Rio de la Magdalena 289, Tizap\u00e1n San \u00c1ngel, Progreso Tizap\u00e1n, \u00c1lvaro Obreg\u00f3n, Ciudad de Mexico 01090, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Larrea","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n \u201cDr. Carlos Gual Castro\u201d, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga No. 15, Belisario Dom\u00ednguez Secci\u00f3n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3365-2932","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Zaga-Clavellina","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Desarrollo Celular, Instituto Nacional de Perinatolog\u00eda Isidro Espinosa de los Reyes, Montes Urales 800, Lomas-Virreyes, Lomas de Chapultepec IV Secci\u00f3n, Miguel Hidalgo, Ciudad de Mexico 11000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5947-4222","authenticated-orcid":false,"given":"Lorenza","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda de la Reproducci\u00f3n \u201cDr. Carlos Gual Castro\u201d, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Av. Vasco de Quiroga No. 15, Belisario Dom\u00ednguez Secci\u00f3n XVI, Tlalpan, Ciudad de Mexico 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,4]]},"reference":[{"key":"ref_1","unstructured":"Wang, Y. (2010). Vasoactivators and Placental Vasoactivity. Vascular Biology of the Placenta, Morgan & Claypool Life Sciences."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.placenta.2008.06.011","article-title":"The functional role of the renin-angiotensin system in pregnancy and preeclampsia","volume":"29","author":"Irani","year":"2008","journal-title":"Placenta"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00006254-199412011-00001","article-title":"Maternal cardiovascular hemodynamic adaptation to pregnancy","volume":"49","author":"Duvekot","year":"1994","journal-title":"Obstet. Gynecol. 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