{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:21:52Z","timestamp":1791894112261,"version":"4.3.4"},"reference-count":210,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: Proper nutrition during pregnancy is important to prevent nutritional imbalances that interfere with pregnancy. Micronutrients play critical roles in embryogenesis, fetal growth, and maternal health, as energy, protein, vitamin, and mineral needs can increase during pregnancy. Increased needs can be met by increasing the intake of dietary micronutrients. Severe micronutrient deficiency or excess during pregnancy can have negative effects on fetal growth (intrauterine growth retardation, low birth weight, or congenital malformations) and pregnancy development (pre-eclampsia or gestational diabetes). We investigate whether it is necessary to continue micronutrient supplementation during pregnancy to improve women\u2019s health in this stage and whether this supplementation could prevent and control pathologies associated with pregnancy. Aim: The present review aims to summarize evidence on the effects of nutritional deficiencies on maternal and newborn morbidity. Methods: This aim is addressed by critically reviewing results from published studies on supplementation with different nutrients during pregnancy. For this, major scientific databases, scientific texts, and official webpages have been consulted. PubMed searches using the terms \u201cpregnancy\u201d OR \u201cmaternal-fetal health\u201d AND \u201cvitamins\u201d OR \u201cminerals\u201d OR \u201csupplementation\u201d AND \u201crequirement\u201d OR \u201cdeficiency nutrients\u201d were performed. Results: There are accepted interventions during pregnancy, such as folic acid supplementation to prevent congenital neural tube defects, potassium iodide supplementation to correct neurodevelopment, and oral iron supplementation during the second half of pregnancy to reduce the risk of maternal anemia and iron deficiency. A number of micronutrients have also been associated with pre-eclampsia, gestational diabetes mellitus, and nausea and vomiting in pregnancy. In general, experimental studies are necessary to demonstrate the benefits of supplementation with different micronutrients and to adjust the recommended daily doses and the recommended periconceptional nutrition for mothers. Conclusions: Presently, there is evidence of the benefits of micronutrient supplementation in perinatal results, but indiscriminate use is discouraged due to the fact that the side effects of excessive doses are not known. Evidence supports the idea that micronutrient deficiencies negatively affect maternal health and the outcome of pregnancy. No single micronutrient is responsible for the adverse effects; thus, supplementing or correcting one deficiency will not be very effective while other deficiencies exist.<\/jats:p>","DOI":"10.3390\/nu13093134","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T10:12:03Z","timestamp":1631095923000},"page":"3134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":98,"title":["Is Supplementation with Micronutrients Still Necessary during Pregnancy? A Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Sonia","family":"Santander Ballest\u00edn","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Physiology and Legal and Forensic Medicine, Faculty of Medicine, University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Isabel","family":"Gim\u00e9nez Campos","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Hospital San Pedro, 26006 Logro\u00f1o, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jara","family":"Ballest\u00edn Ballest\u00edn","sequence":"additional","affiliation":[{"name":"Bioprocess Innovation Unit, ViraTherapeutics GmbH, 6063 Rum, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4071-1467","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Luesma Bartolom\u00e9","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy and Histology, Faculty of Science, University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"ref_1","first-page":"67","article-title":"Funci\u00f3n de los micronutrientes durante el per\u00edodo periconcepcional","volume":"29","author":"Cetin","year":"2010","journal-title":"Rev. Hosp. Matern. Infant. Ram\u00f3n Sard\u00e1"},{"key":"ref_2","unstructured":"Alves, J.G., Ferreira, O.S., and Maggi, R.S. (2004). Introdu\u00e7\u00e3o \u00e0 Nutri\u00e7\u00e3o. Fernando Figueira: Pediatria, MEDSI Editora. [3rd ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1377\/hlthaff.2020.00106","article-title":"Medicaid Expansion Increased Preconception Health Counseling, Folic Acid Intake, and Postpartum Contraception","volume":"39","author":"Myerson","year":"2020","journal-title":"Health Aff."},{"key":"ref_4","first-page":"CD011158","article-title":"Multiple micronutrient powders for home (point-of-use) fortification of foods in pregnant women","volume":"6","author":"Suchdev","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.atherosclerosis.2006.06.008","article-title":"Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subjects","volume":"193","author":"Cazzola","year":"2007","journal-title":"Atherosclerosis"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Massari, M., Novielli, C., Mand\u00f2, C., Di Francesco, S., Della Porta, M., Cazzola, R., Panteghini, M., Savasi, V., Maggini, S., and Schaefer, E. (2020). Multiple Micronutrients and Docosahexaenoic Acid Supplementation during Pregnancy: A Randomized Controlled Study. Nutrients, 12.","DOI":"10.3390\/nu12082432"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Wolf, H.T., Hegaard, H.K., Huusom, L.D., and Pinborg, A. (2017). Multivitamin use and adverse birth outcomes in high-income countries: A systematic review and meta-analysis. Am. J. Obstet. Gynecol., 217.","DOI":"10.1016\/j.ajog.2017.03.029"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Haider, B.A., Yakoob, M.Y., and Bhutta, Z.A. (2011). Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes. BMC Public Health, 11.","DOI":"10.1186\/1471-2458-11-S3-S19"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Mousa, A., Naqash, A., and Lim, S. (2019). Macronutrient and Micronutrient Intake during Pregnancy: An Overview of Recent Evidence. Nutrients, 11.","DOI":"10.3390\/nu11020443"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/nutrit\/nuz101","article-title":"Safety and efficacy of supplements in pregnancy","volume":"78","author":"Brown","year":"2020","journal-title":"Nutr. Rev."},{"key":"ref_11","unstructured":"Moreiras, G.V. (2006). Nutrients in Pregnancy, Team Pharma SL."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"402B","DOI":"10.2471\/BLT.10.083758","article-title":"Maternal multiple micronutrient supplementation and pregnancy outcomes in developing countries: Meta-analysis and meta-regression","volume":"89","author":"Kawai","year":"2011","journal-title":"Bull. World Health Organ."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/bmj.311.6998.171","article-title":"Fetal origins of coronary heart disease","volume":"15","author":"Barker","year":"1995","journal-title":"BMJ"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J. Intern. Med."},{"key":"ref_15","unstructured":"World Health Organization (WHO) (2020, December 20). WHO Recommendations on Antenatal Care for A Positive Pregnancy Experience. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789241549912."},{"key":"ref_16","unstructured":"World Health Organization (WHO) (2021, January 20). WHO Antenatal Care Recommendations for a Positive Pregnancy Experience Nutritional Interventions Update: Multiple Micronutrient Supplements during Pregnancy. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789240007789."},{"key":"ref_17","unstructured":"SE\u00d1: Spanish Nutrition Society [Internet] (2021, March 10). Madrid: SE\u00d1. Available online: http:\/\/www.sennutricion.org\/es\/inicio."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ajog.2020.03.006","article-title":"Iron deficiency in pregnancy","volume":"223","author":"Georgieff","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0021-9258(18)88553-2","article-title":"The necessity of certain lipins in the diet during growth","volume":"15","author":"McCollum","year":"1913","journal-title":"J. Biol. Chem."},{"key":"ref_20","first-page":"271","article-title":"Epidemiology and public health aspects of hypovitaminosis A. A global survey on xerophthalmia","volume":"16","author":"Oomen","year":"1964","journal-title":"Trop. Geogr. Med."},{"key":"ref_21","first-page":"165","article-title":"Recent knowledge about intestinal absorption and cleavage of carotenoids","volume":"63","author":"Borel","year":"2005","journal-title":"Ann. Biol. Clin."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/ajcn\/82.4.821","article-title":"Spinach or carrots can supply significant amounts of vitamin A as assessed by feeding with intrinsically deuterated vegetables","volume":"82","author":"Tang","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0002-8223(01)00078-5","article-title":"Dietary reference intakes: Vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc","volume":"101","author":"Trumbo","year":"2001","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Maia, S.B., Souza, A.S.R., Caminha, M.D.F.C., Da Silva, S.L., Cruz, R.D.S.B.L.C., Dos Santos, C.C., and Filho, M.B. (2019). Vitamin A and Pregnancy: A Narrative Review. Nutrients, 11.","DOI":"10.3390\/nu11030681"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1325S","DOI":"10.1093\/ajcn\/71.5.1325s","article-title":"Vitamin A in pregnancy: Requirements and safety limits","volume":"71","author":"Pascal","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1136\/bmj.317.7170.1460","article-title":"Book: Prevention of Micronutrient Deficiencies: Tools for Policy Makers and Public Health Workers","volume":"317","author":"Bhutta","year":"1998","journal-title":"BMJ"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s00125-008-1009-9","article-title":"Serum concentrations of retinol-binding protein 4 in women with and without gestational diabetes","volume":"51","author":"Krzyzanowska","year":"2008","journal-title":"Diabetologia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/aja.1000920202","article-title":"An analysis of the syndrome of malformations induced by maternal vitamin a deficiency. Effects of restoration of vitamin a at various times during gestation","volume":"92","author":"Wilson","year":"1953","journal-title":"Am. J. Anat."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/jn\/131.3.705","article-title":"Function of Vitamin A in Vertebrate Embryonic Development","volume":"131","author":"Zile","year":"2001","journal-title":"J. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1084\/jem.42.6.753","article-title":"Tissue changes following deprivation of fat-soluble A vitamin","volume":"42","author":"Wolbach","year":"1925","journal-title":"J. Exp. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.semcdb.2011.06.001","article-title":"Vitamin A: A multifunctional tool for development","volume":"22","author":"Theodosiou","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/01480548109018135","article-title":"Teratogenic Effects of Vitamin a Palmitate in Fischer 344 Rats","volume":"4","author":"Hayes","year":"1981","journal-title":"Drug Chem. Toxicol."},{"key":"ref_33","first-page":"9","article-title":"Avitaminosis and congenital malformations","volume":"24","author":"Basu","year":"1983","journal-title":"Int. J. Vitam. Nutr. Res. Suppl. Int. Z. Vitam. Ernahr. Suppl."},{"key":"ref_34","first-page":"CD008666","article-title":"Vitamin A supplementation during pregnancy for maternal and newborn outcomes","volume":"11","author":"Mccauley","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/20477724.2016.1261489","article-title":"Improved infant hemoglobin (Hb) and blood glucose concentrations: The beneficial effect of maternal vitamin A supplementation of malaria-infected mothers in Ebonyi State, Nigeria","volume":"111","author":"Elom","year":"2016","journal-title":"Pathog. Glob. Health"},{"key":"ref_36","first-page":"55","article-title":"Micronutrients and pregnancy outcome","volume":"17","author":"Kolsteren","year":"2001","journal-title":"Stud. Health Serv. Organ. Policy"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/156482650102200303","article-title":"The relationship between vitamin A defi ciency and HIV infection: Review of scientific studies","volume":"22","author":"Coutsoudis","year":"2001","journal-title":"Food Nutr. Bull."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1093\/ajcn\/76.5.1082","article-title":"Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women","volume":"76","author":"Villamor","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13643-020-01501-8","article-title":"Effect of vitamin A, calcium and vitamin D fortification and supplementation on nutritional status of women: An overview of systematic reviews","volume":"9","author":"Rajwar","year":"2020","journal-title":"Syst. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1024\/0300-9831\/a000407","article-title":"Is Diabetes Associated with Lower Vitamin C Status in Pregnant Women? A Prospective Study","volume":"86","author":"Juhl","year":"2016","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1080\/10408398.2020.1744513","article-title":"Discrepancies in global vitamin C recommendations: A review of RDA criteria and underlying health perspectives","volume":"61","author":"Carr","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_42","first-page":"1","article-title":"Supplements in pregnant women: Controversies, evidence and recommendations","volume":"34","year":"2010","journal-title":"Nat. Health Syst."},{"key":"ref_43","unstructured":"Rumbold, A., Ota, E., Hori, H., Miyazaki, C., and Crowther, C.A. (2021, April 09). Vitamin E Supplements during Pregnancy. Available online: http:\/\/www.cochrane.org\/es\/CD004069\/vitamin-e-supplements-during-pregnancy."},{"key":"ref_44","unstructured":"Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids, National Academy Press."},{"key":"ref_45","unstructured":"European Food Safety Authority (EFSA) (2021, July 27). Dietary Reference Values for Nutrients: Summary Report, Available online: https:\/\/www.efsa.europa.eu\/sites\/default\/files\/2017_09_DRVs_summary_report.pdf."},{"key":"ref_46","unstructured":"MIC: Micronutrient Information Center [Internet] (2021, March 10). Oregon: State University. Available online: http:\/\/lpi.oregonstate.edu\/es\/mic."},{"key":"ref_47","unstructured":"NIH: National Institutes of Health [Internet] (2021, May 13). Bethesda: NIH, Available online: https:\/\/ods.od.nih.gov\/factsheets\/VitaminD-DataInSpanish\/."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2147\/IJWH.S34032","article-title":"Vitamin D nutrition in pregnancy: Current opinion","volume":"5","author":"Dawodu","year":"2013","journal-title":"Int. J. Women\u2019s Health"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Mohamed, H.J.J., Rowan, A., Fong, B., and Loy, S.-L. (2014). Maternal Serum and Breast Milk Vitamin D Levels: Findings from the Universiti Sains Malaysia Pregnancy Cohort Study. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100705"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Song, S.J., Zhou, L., Si, S., Liu, J., Zhou, J., Feng, K., Wu, J., and Zhang, W. (2013). The High Prevalence of Vitamin D Deficiency and Its Related Maternal Factors in Pregnant Women in Beijing. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0085081"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Vandevijvere, S., Amsalkhir, S., Van Oyen, H., and Reyes, M.R.M. (2012). High Prevalence of Vitamin D Deficiency in Pregnant Women: A National Cross-Sectional Survey. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0043868"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Cadario, F., Savastio, S., Magnani, C., Cena, T., Pagliardini, V., Bellomo, G., Bagnati, M., Vidali, M., Pozzi, E., and Pamparana, S. (2015). High Prevalence of Vitamin D Deficiency in Native versus Migrant Mothers and Newborns in the North of Italy: A Call to Act with a Stronger Prevention Program. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129586"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/cen.12751","article-title":"Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome","volume":"83","author":"Sablok","year":"2015","journal-title":"Clin. Endocrinol."},{"key":"ref_54","first-page":"1521","article-title":"Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness","volume":"25","author":"Hollis","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s00223-012-9607-4","article-title":"Vitamin D and Pregnancy: Skeletal Effects, Nonskeletal Effects, and Birth Outcomes","volume":"92","author":"Hollis","year":"2012","journal-title":"Calcif. Tissue Int."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000486810","article-title":"Maternal Vitamin D Status and Risk of Gestational Diabetes: A Meta-Analysis","volume":"45","author":"Hu","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Zhang, C., Qiu, C., Hu, F.B., David, R.M., van Dam, R., Bralley, A., and Williams, M.A. (2008). Maternal Plasma 25-Hydroxyvitamin D Concentrations and the Risk for Gestational Diabetes Mellitus. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0003753"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"O\u2019Callaghan, K.M., and Kiely, M. (2018). Systematic Review of Vitamin D and Hypertensive Disorders of Pregnancy. Nutrients, 10.","DOI":"10.3390\/nu10030294"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1210\/jc.2010-0996","article-title":"A Nested Case-Control Study of Midgestation Vitamin D Deficiency and Risk of Severe Preeclampsia","volume":"95","author":"Baker","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3109\/14767058.2013.765849","article-title":"Maternal vitamin D status and adverse pregnancy outcomes: A systematic review and meta-analysis","volume":"26","author":"Wei","year":"2013","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Xu, L., Lee, M., Jeyabalan, A., and Roberts, J.M. (2013). The relationship of hypovitaminosis D and IL-6 in preeclampsia. Am. J. Obstet. Gynecol., 210.","DOI":"10.1016\/j.ajog.2013.09.037"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/mcn.12058","article-title":"The relationship of serum vitamin D with pre-eclampsia in the Iranian women","volume":"10","author":"Abedi","year":"2013","journal-title":"Matern. Child Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.annepidem.2016.09.015","article-title":"Low maternal 25-hydroxyvitamin D concentration increases the risk of severe and mild preeclampsia","volume":"26","author":"Baca","year":"2016","journal-title":"Ann. Epidemiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1111\/j.1471-0528.2010.02742.x","article-title":"Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia","volume":"117","author":"Shand","year":"2010","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Khaing, W., Vallibhakara, S.A.-O., Tantrakul, V., Vallibhakara, O., Rattanasiri, S., McEvoy, M., Attia, J., and Thakkinstian, A. (2017). Calcium and Vitamin D Supplementation for Prevention of Preeclampsia: A Systematic Review and Network Meta-Analysis. Nutrients, 9.","DOI":"10.3390\/nu9101141"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/AOG.0b013e3182941d9a","article-title":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network. Maternal 25-Hydroxyvitamin D and preterm birth in twin gestations","volume":"122","author":"Bodnar","year":"2013","journal-title":"Obstet. Gynecol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijgo.2011.07.029","article-title":"First-trimester maternal serum 25-hydroxyvitamin D3status and pregnancy outcome","volume":"116","author":"Alonso","year":"2011","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3945\/ajcn.113.065672","article-title":"Effects of maternal serum 25-hydroxyvitamin D concentrations in the first trimester on subsequent pregnancy outcomes in an Australian population","volume":"99","author":"Schneuer","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_69","first-page":"287","article-title":"Serum 25-Hydroxyvitamin D in pregnant women during preterm labor","volume":"26","author":"Bhupornvivat","year":"2017","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1111\/j.1471-0528.2012.03495.x","article-title":"Vitamin D status and recurrent preterm birth: A nested case-control study in high-risk women","volume":"119","author":"Thorp","year":"2012","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1210\/jc.2007-0718","article-title":"Maternal Vitamin D Deficiency Increases the Risk of Preeclampsia","volume":"92","author":"Bodnar","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"McDonnell, S.L., Baggerly, K.A., Baggerly, C.A., Aliano, J.L., French, C.B., Baggerly, L.L., Ebeling, M.D., Rittenberg, C.S., Goodier, C.G., and Ni\u00f1o, J.F.M. (2017). Maternal 25(OH)D concentrations \u226540 ng\/mL associated with 60% lower preterm birth risk among general obstetrical patients at an urban medical center. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180483"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jsbmb.2015.10.022","article-title":"Post-hoc analysis of vitamin D status and reduced risk of preterm birth in two vitamin D pregnancy cohorts compared with South Carolina March of Dimes 2009\u20132011 rates","volume":"155","author":"Wagner","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Wang, Z., Ding, R., and Wang, J. (2020). The Association between Vitamin D Status and Autism Spectrum Disorder (ASD): A Systematic Review and Meta-Analysis. Nutrients, 13.","DOI":"10.3390\/nu13010086"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Van der Pligt, P., Willcox, J., Szymlek-Gay, E.A., Murray, E., Worsley, A., and Daly, R.M. (2018). Associations of maternal vitamin D deficiency with pregnancy and neonatal complications in developing countries: A systematic review. Nutrients, 10.","DOI":"10.3390\/nu10050640"},{"key":"ref_76","unstructured":"Shils, M.E., Shike, M., Ross, A.C., Caballero, B., and Cousins, R.J. (2006). Modern Nutrition in Health and Disease, Lippincott Williams & Wilkins."},{"key":"ref_77","unstructured":"Davidson, L.S.P., Passmore, R., and Eastwood, M.A. (1986). Human Nutrition and Dietetics, Churchill Livingstone."},{"key":"ref_78","first-page":"358","article-title":"Coumarin embryopathy in an extremely low birth weight infant associated with neonatal hepatitis and ocular malformations","volume":"165","author":"Hetzel","year":"2006","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/humupd\/dmn057","article-title":"Reproductive outcome after bariatric surgery: A critical review","volume":"15","author":"Guelinckx","year":"2008","journal-title":"Hum. Reprod. Update"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-29616-y","article-title":"Vitamin K supplementation during pregnancy for improving outcomes: A systematic review and meta-analysis","volume":"8","author":"Shahrook","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.nut.2009.12.003","article-title":"Micronutrient deficiencies after bariatric surgery","volume":"26","author":"Shankar","year":"2010","journal-title":"Nutrition"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/aje\/kwm078","article-title":"Preconception B-Vitamin and Homocysteine Status, Conception, and Early Pregnancy Loss","volume":"166","author":"Ronnenberg","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ejcn.2009.125","article-title":"Vitamin B6 deficiency and anemia in pregnancy","volume":"64","author":"Hisano","year":"2010","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-3016.2012.01277.x","article-title":"Interventions with Vitamins B6, B12 and C in Pregnancy","volume":"26","author":"Dror","year":"2012","journal-title":"Paediatr. P\u00e9rinat. Epidemiol."},{"key":"ref_85","first-page":"CD007575","article-title":"Interventions for nausea and vomiting in early pregnancy","volume":"9","author":"Matthews","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/01443610600955826","article-title":"Pregnancy outcome following use of large doses of vitamin B6in the first trimester","volume":"26","author":"Shrim","year":"2006","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/bdra.10034","article-title":"Bendectin and birth defects. II: Ecological analyses","volume":"67","author":"Kutcher","year":"2003","journal-title":"Birth Defects Res. Part A Clin. Mol. Teratol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/ajo.13341","article-title":"Vitamin B3 levels in women who experience first-trimester miscarriage","volume":"61","author":"Yakob","year":"2021","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_89","first-page":"279","article-title":"Neurology and pregnancy","volume":"48","author":"Fuentes","year":"2010","journal-title":"Rev. Chil. Neuro Psiquiatr."},{"key":"ref_90","first-page":"97","article-title":"Encefalopat\u00eda de Wernicke como complicaci\u00f3n de la hyperemesis grav\u00eddica","volume":"52","year":"2009","journal-title":"Rev. Fac. Med. UNAM"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/01.ogx.0000206336.08794.65","article-title":"Hyperemesis Gravidarum Complicated by Wernicke Encephalopathy: Background, Case Report, and Review of the Literature","volume":"61","author":"Chiossi","year":"2006","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_92","first-page":"822","article-title":"A rare complication of vomiting in pregnancy: Wernicke\u2019s encephalopathy","volume":"35","author":"Grall","year":"2006","journal-title":"J. Gynecol. Obstet. Biol. Reprod."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11065-012-9196-z","article-title":"The Evolution and Treatment of Korsakoff\u2019s Syndrome","volume":"22","author":"Thomson","year":"2012","journal-title":"Neuropsychol. Rev."},{"key":"ref_94","first-page":"137","article-title":"S\u00edncopes de repetici\u00f3n como presentaci\u00f3n de encefalopat\u00eda de Wernicke-Korsakoff","volume":"3","year":"2010","journal-title":"Rev. Clin. Med. Fam."},{"key":"ref_95","first-page":"99","article-title":"Administration of folic acid and other micronutrients in pregnant women in Colombia","volume":"34","year":"2013","journal-title":"Rev. Panam. Salud Publica"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12884-021-03893-4","article-title":"Knowledge and intake of folic acid to prevent neural tube defects among pregnant women in urban China: A cross-sectional study","volume":"21","author":"Cui","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000491786","article-title":"Folic Acid Supplementation to Prevent Recurrent Neural Tube Defects: 4 Milligrams Is Too Much","volume":"44","author":"Dolin","year":"2018","journal-title":"Fetal Diagn. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/adc.51.12.944","article-title":"Vitamin deficiencies and neural tube defects","volume":"51","author":"Smithells","year":"1976","journal-title":"Arch. Dis. Child."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1136\/bmj.282.6275.1509","article-title":"Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects","volume":"282","author":"Laurence","year":"1981","journal-title":"Br. Med. J. Clin. Res. Ed."},{"key":"ref_100","first-page":"CD004905","article-title":"Multiple-micronutrient supplementation for women during pregnancy","volume":"3","author":"Keats","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","article-title":"Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation","volume":"327","author":"Czeizel","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1056\/NEJM199911113412001","article-title":"Prevention of Neural-Tube Defects with Folic Acid in China. U.S. Collaborative Project for Neural Tube Defect Prevention","volume":"341","author":"Berry","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/ppe.12414","article-title":"Maternal Multivitamin Intake, Plasma Folate and Vitamin B12Levels and Autism Spectrum Disorder Risk in Offspring","volume":"32","author":"Raghavan","year":"2017","journal-title":"Paediatr. P\u00e9rinat. Epidemiol."},{"key":"ref_104","first-page":"519","article-title":"Homocysteine and Folate Levels as Risk Factors for Recurrent Early Pregnancy Loss","volume":"95","author":"Nelen","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1471-0528.2000.tb11095.x","article-title":"Elevated circulating homocyst(e)ine levels in placental vascular disease and associated pre-eclampsia","volume":"107","author":"Wang","year":"2000","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1002\/ijc.24969","article-title":"Maternal folate and other vitamin supplementation during pregnancy and risk of acute lymphoblastic leukemia in the offspring","volume":"126","author":"Milne","year":"2010","journal-title":"Int. J. Cancer"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3961\/jpmph.19.020","article-title":"The Protective Effect of Maternal Folic Acid Supplementation on Childhood Cancer: A Systematic Review and Meta-analysis of Case-control Studies","volume":"52","author":"Ismail","year":"2019","journal-title":"J. Prev. Med. Public Health"},{"key":"ref_108","unstructured":"EUROCAT Folic Acid Working Group (2009). Prevention of Neural Tube Defects by Periconceptional Folic Acid Supplementation in Europe, EUROCAT Central Registry."},{"key":"ref_109","unstructured":"World Health Organization (2020, July 31). e-Library of Evidence for Nutrition Actions (eLENA) Daily Iron and Folic Acid Supplementation during Pregnancy. Available online: https:\/\/www.who.int\/elena\/titles\/guidance_summaries\/daily_iron_pregnancy\/en\/."},{"key":"ref_110","unstructured":"Direccion General de Salud Publica, Ministerio de Sanidad y Consumo (2001). Recomendaciones sobre suplementacion con \u00e1cido folico para la prevencion de defectos del tubo neural. Inf. Ter. Sist. Nac. Salud., 25, 66\u201367."},{"key":"ref_111","unstructured":"Sociedad Espa\u00f1ola de Ginecolog\u00eda y Obstetricia (2018). Control prenatal del embarazo normal. Prog. Obstet. Ginecol., 61, 510\u2013527. Available online: https:\/\/sego.es\/documentos\/progresos\/v61-2018\/n5\/GAP_Conatrol%20prenatal%20del%20embarazo%20normal_6105.pdf."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/S1701-2163(16)32685-8","article-title":"Pre-conceptional vitamin\/folic acid supplementation 2007: The use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies","volume":"29","author":"Wilson","year":"2007","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1111\/j.1476-5381.2009.00492.x","article-title":"[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C\u2192T polymorphism of methylenetetrahydrofolate reductase","volume":"158","author":"Tobolski","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1177\/15648265080292S117","article-title":"Effects of Vitamin B12 and Folate Deficiency on Brain Development in Children","volume":"29","author":"Black","year":"2008","journal-title":"Food Nutr. Bull."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1177\/15648265080292S114","article-title":"Effects of Folate and Vitamin B12 Deficiencies During Pregnancy on Fetal, Infant, and Child Development","volume":"29","author":"Molloy","year":"2008","journal-title":"Food Nutr. Bull."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-68344-0","article-title":"Vitamin B12 deficiency and altered one-carbon metabolites in early pregnancy is associated with maternal obesity and dyslipidaemia","volume":"10","author":"Adaikalakoteswari","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/ejcn.2017.29","article-title":"Vitamin B12 status in pregnant women and their infants in South India","volume":"71","author":"Finkelstein","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1753-4887.2012.00491.x","article-title":"Role of calcium during pregnancy: Maternal and fetal needs","volume":"70","author":"Hacker","year":"2012","journal-title":"Nutr. Rev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S8756-3282(03)00017-6","article-title":"Longitudinal changes in bone mineral density during normal pregnancy","volume":"32","author":"Kaur","year":"2003","journal-title":"Bone"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1530\/eje.0.1370402","article-title":"Calcium-regulating hormones and parathyroid hormone-related peptide in normal human pregnancy and postpartum: A longitudinal study","volume":"137","author":"Ardawi","year":"1997","journal-title":"Eur. J. Endocrinol."},{"key":"ref_121","first-page":"317","article-title":"Bone calcium turnover during pregnancy and lactation in woman with low calcium diets is associated with calcium intake and circulating insulin-like growth factor 1 concentrations","volume":"83","author":"Donangelo","year":"2006","journal-title":"Am. J. Clin. Endocrinol. Metab."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/ppe.12476","article-title":"Maternal folic acid supplementation for the prevention of preeclampsia: A systematic review and meta-analysis","volume":"32","author":"Bulloch","year":"2018","journal-title":"Paediatr. P\u00e9rinat. Epidemiol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1001\/jama.1996.03530370054031","article-title":"Effects of dietary calcium supplementation on blood preassure: A meta-analysis of randomized controlled trials","volume":"275","author":"Bucher","year":"1996","journal-title":"JAMA"},{"key":"ref_124","first-page":"CD001059","article-title":"Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems","volume":"2018","author":"Hofmeyr","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_125","first-page":"CD000937","article-title":"Magnesium supplementation in pregnancy","volume":"2019","author":"Makrides","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.atherosclerosis.2012.01.034","article-title":"Associations of dietary magnesium intake with mortality from cardiovascular disease: The JACC study","volume":"221","author":"Zhang","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4843159","article-title":"Magnesium Supplementation and Blood Pressure in Pregnancy: A Double-Blind Randomized Multicenter Study","volume":"2018","author":"Bullarbo","year":"2018","journal-title":"J. Pregnancy"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1017\/S1368980007360886","article-title":"The importance of iodine nutrition during pregnancy","volume":"10","author":"Glinoer","year":"2007","journal-title":"Public Health Nutr."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1017\/S1368980007360928","article-title":"Iodine deficiency and brain development in the first half of pregnancy","volume":"10","year":"2007","journal-title":"Public Health Nutr."},{"key":"ref_130","unstructured":"Morreale de Escobar, G. (2004). Yodo y Embarazo. En Yodo y Salud en el Siglo XXI, European Pharmaceutical Law Group."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJM199908193410801","article-title":"Maternal Thyroid Deficiency during Pregnancy and Subsequent Neuropsychological Development of the Child","volume":"341","author":"Haddow","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_132","unstructured":"World Health Organization (2001). Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination: A Guide for Programme Managers, World Health Organization. [2nd ed.]. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/61278."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/ijlh.12505","article-title":"The mutual control of iron and erythropoiesis","volume":"38","author":"Camaschella","year":"2016","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/jp.2017.43","article-title":"Iron supplementation in singleton pregnancy: Is there a benefit to doubling the dose of elemental iron in iron-deficient pregnant women? a randomized controlled trial","volume":"37","author":"Shinar","year":"2017","journal-title":"J. Perinatol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"F1125","DOI":"10.1152\/ajprenal.00129.2016","article-title":"The enigma of continual plasma volume expansion in pregnancy: Critical role of the renin-angiotensin-aldosterone system","volume":"311","author":"West","year":"2016","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/zoo.21083","article-title":"Hematological and serum biochemical analytes reflect physiological challenges during gestation and lactation in killer whales (Orcinus orca)","volume":"32","author":"Robeck","year":"2013","journal-title":"Zoo Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1034\/j.1600-0412.1999.780902.x","article-title":"Iron status and iron balance during pregnancy. A critical reappraisal of iron supplementation","volume":"78","author":"Milman","year":"1999","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00277-008-0518-4","article-title":"Prepartum anaemia: Prevention and treatment","volume":"87","author":"Milman","year":"2008","journal-title":"Ann. Hematol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/s41430-019-0400-6","article-title":"A systematic literature review of the relation between iron status\/anemia in pregnancy and offspring neurodevelopment","volume":"73","author":"Janbek","year":"2019","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_140","first-page":"76","article-title":"Relationship between maternal DHA and iron status and infants\u2019 cognitive performance","volume":"72","author":"Rioux","year":"2011","journal-title":"Can. J. Diet. Pract. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000480742","article-title":"Iron and cognitive development: What Is the evidence?","volume":"71","author":"Larson","year":"2017","journal-title":"Ann. Nutr. Metab."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1600-0412.2000.079002089.x","article-title":"Hemoglobin and erythrocyte indices during normal pregnancy and postpartum in 206 women with and without iron supplementation","volume":"79","author":"Milman","year":"2000","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"American College of Obstetrics & Gynecology (2008). ACOG Practice Bulletin No. 95: Anemia in pregnancy. Obstet. Gynecol., 112, 201\u2013207.","DOI":"10.1097\/AOG.0b013e3181809c0d"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/bjh.16221","article-title":"UK guidelines on the management of iron deficiency in pregnancy","volume":"188","author":"Pavord","year":"2019","journal-title":"Br. J. Haematol."},{"key":"ref_145","first-page":"95","article-title":"Assessment of Iron Deficiency and Anemia in Pregnant Women: An Observational French Study","volume":"12","author":"Harvey","year":"2016","journal-title":"Women\u2019s Health"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/M15-1707","article-title":"Screening for Iron Deficiency Anemia and Iron Supplementation in Pregnant Women to Improve Maternal Health and Birth Outcomes: U.S. Preventive Services Task Force Recommendation Statement","volume":"163","author":"Siu","year":"2015","journal-title":"Ann. Intern. Med."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00277-006-0145-x","article-title":"Iron prophylaxis in pregnancy\u2014General or individual and in which dose?","volume":"85","author":"Milman","year":"2006","journal-title":"Ann. Hematol."},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Means, R.T. (2020). Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters. Nutrients, 12.","DOI":"10.3390\/nu12020447"},{"key":"ref_149","first-page":"CD009997","article-title":"Intermittent oral iron supplementation during pregnancy","volume":"2015","author":"Malave","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Grzeszczak, K., Kwiatkowski, S., and Kosik-Bogacka, D. (2020). The Role of Fe, Zn, and Cu in Pregnancy. Biomolecules, 10.","DOI":"10.3390\/biom10081176"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0140-6736(00)04260-4","article-title":"Zinc supplementation during pregnancy and effects on growth and morbidity in low birthweight infants: A randomized placebo controlled trial","volume":"357","author":"Osendarp","year":"2001","journal-title":"Lancet"},{"key":"ref_152","first-page":"CD000230","article-title":"Zinc supplementation for improving pregnancy and infant outcome","volume":"2021","author":"Carducci","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"782","DOI":"10.3390\/nu4070782","article-title":"Maternal zinc intakes and homeostatic adjustments during pregnancy and lactation","volume":"4","author":"Donangelo","year":"2012","journal-title":"Nutrients"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/1297658","article-title":"Selenium and Thyroid Disease: From Pathophysiology to Treatment","volume":"2017","author":"Ventura","year":"2017","journal-title":"Int. J. Endocrinol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/thy.2016.0457","article-title":"2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease during Pregnancy and the Postpartum","volume":"27","author":"Alexander","year":"2017","journal-title":"Thyroid"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13044-020-00090-x","article-title":"Selenium and at-risk pregnancy: Challenges and controversies","volume":"13","author":"Duntas","year":"2020","journal-title":"Thyroid. Res."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.bbagen.2009.03.015","article-title":"Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium","volume":"1790","author":"Schomburg","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Gen. Subj."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1210\/jc.2006-1821","article-title":"The Influence of Selenium Supplementation on Postpartum Thyroid Status in Pregnant Women with Thyroid Peroxidase Autoantibodies","volume":"92","author":"Negro","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000447667","article-title":"A 2016 Italian Survey about the Clinical Use of Selenium in Thyroid Disease","volume":"5","author":"Negro","year":"2016","journal-title":"Eur. Thyroid. J."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/14767058.2016.1274299","article-title":"Evaluating the effects of copper supplement during pregnancy on premature rupture of membranes and pregnancy outcome","volume":"31","author":"Kashanian","year":"2017","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-277X.2004.00552.x","article-title":"The health benefits of omega-3 polyunsaturated fatty acids: A review of the evidence","volume":"17","author":"Ruxton","year":"2004","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1194\/jlr.M400514-JLR200","article-title":"Compartmental modeling to quantify \u03b1-linolenic acid conversion after longer term intake of multiple tracer boluses","volume":"46","author":"Goyens","year":"2005","journal-title":"J. Lipid Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1194\/jlr.M400225-JLR200","article-title":"Long-chain conversion of [13C]linoleic acid and \u03b1-linolenic acid in response to marked changes in their dietary intake in men","volume":"46","author":"Hussein","year":"2005","journal-title":"J. Lipid Res."},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Thompson, M., Hein, N., Hanson, C., Smith, L.M., Anderson-Berry, A., Richter, C.K., Bisselou, K.S., Appiah, A.K., Kris-Etherton, P., and Skulas-Ray, A.C. (2019). Omega-3 Fatty Acid Intake by Age, Gender, and Pregnancy Status in the United States: National Health and Nutrition Examination Survey 2003\u20132014. Nutrients, 11.","DOI":"10.3390\/nu11010177"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.plefa.2018.11.007","article-title":"Very low inadequate dietary intakes of essential n-3 polyunsaturated fatty acids (PUFA) in pregnant and lactating French women: The INCA2 survey","volume":"140","author":"Tressou","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"381","DOI":"10.32394\/rpzh.2018.0044","article-title":"Dietary intake of DHA during pregnancy: A significant gap between the actual intake and current nutritional recommendations","volume":"69","author":"Wierzejska","year":"2018","journal-title":"Rocz. Pa\u0144stwowego Zak\u0142adu Hig."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"von Schacky, C. (2020). Omega-3 Fatty Acids in Pregnancy\u2014The Case for a Target Omega-3 Index. Nutrients, 12.","DOI":"10.3390\/nu12040898"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1055\/a-0713-1058","article-title":"Diet and Lifestyle Before and During Pregnancy\u2014Practical Recommendations of the Germany-wide Healthy Start\u2014Young Family Network","volume":"78","author":"Koletzko","year":"2018","journal-title":"Geburtshilfe Frauenheilkd."},{"key":"ref_169","first-page":"163","article-title":"Omega-3 Fatty acids and pregnancy","volume":"3","author":"Coletta","year":"2010","journal-title":"Rev. Obstet. Gynecol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1017\/S0007114507764747","article-title":"Dietary fat intakes for pregnant and lactating women","volume":"98","author":"Koletzko","year":"2007","journal-title":"Br. J. Nutr."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.plefa.2019.10.002","article-title":"Relationships between seafood consumption during pregnancy and childhood and neurocognitive development: Two systematic reviews","volume":"151","author":"Hibbeln","year":"2019","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1055\/a-0903-2671","article-title":"Prevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015\/025, February 2019)\u2014Part 1 with Recommendations on the Epidemiology, Etiology, Prediction, Primary and Secondary Prevention of Preterm Birth","volume":"79","author":"Berger","year":"2019","journal-title":"Geburtshilfe Frauenheilkd."},{"key":"ref_173","first-page":"CD003402","article-title":"Omega-3 fatty acid addition during pregnancy","volume":"2018","author":"Middleton","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ebiom.2018.07.009","article-title":"Plasma Concentrations of Long Chain N-3 Fatty Acids in Early and Mid-Pregnancy and Risk of Early Preterm Birth","volume":"35","author":"Olsen","year":"2018","journal-title":"EBioMedicine"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/ajcn\/nqy079","article-title":"Long-chain polyunsaturated fatty acids, gestation duration, and birth size: A Mendelian randomization study using fatty acid desaturase variants","volume":"108","author":"Bernard","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_176","unstructured":"Hern\u00e1ndez, S., G\u00f3mez, D., Bellart, J., Domenech, M., and Peguero, A. (2017). Hypertension and pregnancy protocol. Matern.-Fetal Med. Protoc. Hosp. Clin. Barc., 1\u201321."},{"key":"ref_177","unstructured":"American College of Obstetricians and Gynecologists Hypertension in Pregnancy (2013). Report of the American College of Obstetricians and Gynecologists\u2019 task force on hypertension in pregnancy. Obstet. Gynecol., 122, 1122."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3389\/fphys.2018.00973","article-title":"Preeclampsia: Novel Mechanisms and Potential Therapeutic Approaches","volume":"9","author":"Armaly","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_179","unstructured":"Hern\u00e1ndez, J.C., Garc\u00eda, P.H., Quesada, M.Y., and Vald\u00e9s, A.I. (2007). Factores de riesgo de preeclampsia. Rev. Cuba. Med. Gen. Integr., 23, Available online: http:\/\/scielo.sld.cu\/scielo.php?script=sci_arttext&pid=S0864-21252007000400012."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"R693","DOI":"10.1152\/ajpregu.00259.2017","article-title":"Immune regulation of systemic hypertension, pulmonary arterial hypertension, and preeclampsia: Shared disease mechanisms and translational opportunities","volume":"313","author":"Jafri","year":"2017","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Devarshi, P.P., Grant, R.W., Ikonte, C.J., and Mitmesser, S.H. (2019). Maternal Omega-3 Nutrition, Placental Transfer and Fetal Brain Development in Gestational Diabetes and Preeclampsia. Nutrients, 11.","DOI":"10.3390\/nu11051107"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00001648-199505000-00007","article-title":"Omega-3 fatty acids in maternal erythrocytes and risk of preeclampsia","volume":"6","author":"Williams","year":"1995","journal-title":"Epidemiology"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/hr.2010.31","article-title":"Circulating angiogenic factors and their association with birth outcomes in preeclampsia","volume":"33","author":"Kulkarni","year":"2010","journal-title":"Hypertens. Res."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Fulgoni, V.L., Kris-Etherton, P.M., and Mitmesser, S.H. (2018). Dietary Intakes of EPA and DHA Omega-3 Fatty Acids among US Childbearing-Age and Pregnant Women: An Analysis of NHANES 2001\u20132014. Nutrients, 10.","DOI":"10.3390\/nu10040416"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.plefa.2017.08.002","article-title":"Maternal long chain polyunsaturated fatty acid status and pregnancy complications","volume":"136","author":"Wadhwani","year":"2018","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.plefa.2014.05.006","article-title":"Altered maternal proportions of long chain polyunsaturated fatty acids and their transport leads to disturbed fetal stores in preeclampsia","volume":"91","author":"Wadhwani","year":"2014","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"ref_187","first-page":"194","article-title":"Fisiopatolog\u00eda y factores etiopatog\u00e9nicos de la hipertensi\u00f3n arterial en el embarazo. Revisi\u00f3n de la literatura","volume":"59","author":"Costales","year":"2000","journal-title":"Toko-Gin Pract."},{"key":"ref_188","first-page":"43","article-title":"Elevated serum B-hCG levels in severe preeclampsia","volume":"30","author":"Balat","year":"2000","journal-title":"Turk. J. Med. Sci."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","article-title":"Lastet advances in understanding preeclampsia","volume":"308","author":"Redman","year":"2005","journal-title":"Science"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/00001703-200204000-00004","article-title":"Hypertensive diseases and eclampsia","volume":"14","author":"Myers","year":"2002","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00006254-200301000-00022","article-title":"Molecular Epidemiology of Preeclampsia","volume":"58","author":"Wilson","year":"2003","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/00006254-200209000-00024","article-title":"Preeclampsia. Experimental and genetic considerations","volume":"57","author":"Pridjian","year":"2002","journal-title":"Obstet. Gynecol. Survey"},{"key":"ref_193","first-page":"39","article-title":"Parenteral nutrition during pregnancy. Lack of association with idiopathic preterm labor or preeclampsia","volume":"39","author":"Greenspoon","year":"1994","journal-title":"J. Reprod. Med."},{"key":"ref_194","first-page":"237","article-title":"Calcium and pregnancy","volume":"24","author":"Herrera","year":"2013","journal-title":"Rev. Med. Hered."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"31","DOI":"10.25100\/cm.v35i.1.284","article-title":"Efectos en la suplementaci\u00f3n oral con calcio y \u00e1cido lenoleico conjugado en primigr\u00e1vidas de alto riesgo","volume":"35","author":"Herrera","year":"2004","journal-title":"Colomb. Med."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/10641955.2019.1593445","article-title":"The association between calcium supplement and preeclampsia and gestational hypertension: A systematic review and meta-analysis of randomized trials","volume":"38","author":"Sun","year":"2019","journal-title":"Hypertens. Pregnancy"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/MCO.0000000000000462","article-title":"Nutritional approach to preeclampsia prevention","volume":"21","author":"Achamrah","year":"2018","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11892-019-1199-1","article-title":"Nutritional Supplementation for the Prevention and\/or Treatment of Gestational Diabetes Mellitus","volume":"19","author":"Plows","year":"2019","journal-title":"Curr. Diabetes Rep."},{"key":"ref_199","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2018). Classification and diagnosis of diabetes: Standards of medical care in diabetes\u20142018. Diabetes Care, 41, S13\u2013S27.","DOI":"10.2337\/dc18-S002"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1080\/14767058.2018.1526916","article-title":"The impact of omega-3 fatty acid supplementation on glycemic control in patients with gestational diabetes: A systematic review and meta-analysis of randomized controlled studies","volume":"33","author":"Gao","year":"2018","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_201","first-page":"49","article-title":"Vitamin C and the risk of gestational diabetes mellitus: A case-control study","volume":"49","author":"Zhang","year":"2004","journal-title":"J. Reprod. Med."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"8366","DOI":"10.3390\/nu7105398","article-title":"Vitamin D Deficiency Increases the Risk of Gestational Diabetes Mellitus: A Meta-Analysis of Observational Studies","volume":"7","author":"Zhang","year":"2015","journal-title":"Nutrients"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7762\/cnr.2017.6.2.81","article-title":"Antioxidant Status and Risk of Gestational Diabetes Mellitus: A Case-Control Study","volume":"6","author":"Parast","year":"2017","journal-title":"Clin. Nutr. Res."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10719-016-9688-9","article-title":"Dysfunctional protection against advanced glycation due to thiamine metabolism abnormalities in gestational diabetes","volume":"33","author":"Tomandl","year":"2016","journal-title":"Glycoconj. J."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Sukumar, N., Venkataraman, H., Wilson, S., Goljan, I., Selvamoni, S., Patel, V., and Saravanan, P. (2016). Vitamin B12 Status among Pregnant Women in the UK and Its Association with Obesity and Gestational Diabetes. Nutrients, 8.","DOI":"10.3390\/nu8120768"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.nut.2004.05.022","article-title":"Gestational hyperglycemia, zinc, selenium, and antioxidant vitamins","volume":"21","author":"Bo","year":"2005","journal-title":"Nutrition"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1017\/S0007114516003202","article-title":"The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort","volume":"116","author":"Boyle","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-277X.2009.01019.x","article-title":"Dietary and clinical impacts of nausea and vomiting during pregnancy","volume":"23","author":"Isolauri","year":"2010","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0301-2115(98)00061-X","article-title":"Periconceptional folic acid containing multivitamin supplementation","volume":"78","author":"Czeizel","year":"1998","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Persaud, N., Meaney, C., El-Emam, K., Moineddin, R., and Thorpe, K. (2018). Doxylamine-pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0189978"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/9\/3134\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:59:00Z","timestamp":1760165940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/9\/3134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,8]]},"references-count":210,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["nu13093134"],"URL":"https:\/\/doi.org\/10.3390\/nu13093134","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,8]]}}}