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Because of the lack of effective treatments for intestinal fibrosis, there is an urgent need to develop new therapies. Factors promoting intestinal fibrosis are currently unclear, but diet is a potential culprit. Diet may influence predisposition to develop intestinal fibrosis or alter its natural history by modification of both the host immune response and intestinal microbial composition. Few studies have documented the effects of dietary factors in modulating IBD-induced intestinal fibrosis. As the mechanisms behind fibrogenesis in the gut are believed to be broadly similar to those from extra-intestinal organs, it may be relevant to investigate which dietary components can inhibit or promote fibrosis factors such as myofibroblasts progenitor activation in other fibrotic diseases.<\/jats:p>","DOI":"10.3390\/nu13093148","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T21:36:58Z","timestamp":1631223418000},"page":"3148","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diet in Intestinal Fibrosis: A Double-Edged Sword"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3006-5943","authenticated-orcid":false,"given":"Rachel","family":"Marion-Letellier","sequence":"first","affiliation":[{"name":"UNIROUEN, INSERM UMR 1073 Nutrition, Inflammation and Gut-Brain Axis, Normandie University, 76183 Rouen, France"},{"name":"Institute for Research and Innovation in Biomedicine (IRIB), UNIROUEN, 76183 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-8960","authenticated-orcid":false,"given":"Mathilde","family":"Leboutte","sequence":"additional","affiliation":[{"name":"UNIROUEN, INSERM UMR 1073 Nutrition, Inflammation and Gut-Brain Axis, Normandie University, 76183 Rouen, France"},{"name":"Institute for Research and Innovation in Biomedicine (IRIB), UNIROUEN, 76183 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Amamou","sequence":"additional","affiliation":[{"name":"APC Microbiome Ireland, Biosciences Building, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9129-3632","authenticated-orcid":false,"given":"Maitreyi","family":"Raman","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, University of Calgary, Calgary, AB T2N 4N1, Canada"},{"name":"Department of Community Health Sciences, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Savoye","sequence":"additional","affiliation":[{"name":"UNIROUEN, INSERM UMR 1073 Nutrition, Inflammation and Gut-Brain Axis, Normandie University, 76183 Rouen, France"},{"name":"Institute for Research and Innovation in Biomedicine (IRIB), UNIROUEN, 76183 Rouen, France"},{"name":"Department of Gastroenterology, Rouen University Hospital, 76031 Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrata","family":"Ghosh","sequence":"additional","affiliation":[{"name":"APC Microbiome Ireland, Biosciences Building, University College Cork, Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/ibd\/izy331","article-title":"The Mesenteric Fat and Intestinal Muscle Interface: Creeping Fat Influencing Stricture Formation in Crohn\u2019s Disease","volume":"25","author":"Mao","year":"2019","journal-title":"Inflamm. 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