{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:53:27Z","timestamp":1791672807391,"version":"4.3.4"},"reference-count":192,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN204821"],"award-info":[{"award-number":["IN204821"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN205020"],"award-info":[{"award-number":["IN205020"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007161","name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado, Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["20195823"],"award-info":[{"award-number":["20195823"]}],"id":[{"id":"10.13039\/501100007161","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Gastric ulcer disease induced by the consumption of NSAIDs is a major public health problem. The therapy used for its treatment causes adverse effects in the patient. Propolis is a natural product that has been used for the treatments of different diseases around the world. Nevertheless, there is little information about the activity of propolis in gastric ulcers caused by treatment with NSAIDs. Therefore, this review evaluates and compares the gastroprotective potential of propolis and its function against NSAID-induced gastric ulcers, for which a systematic search was carried out in the PubMed and ScienceDirect databases. The main criteria were articles that report the gastroprotective activity of propolis against the damage produced by NSAIDs in the gastric mucosa. Gastroprotection was related to the antioxidant, antisecretory, and cytoprotective effects, as well as the phenolic compounds present in the chemical composition of propolis. However, most of the studies used different doses of NSAIDs and propolis and evaluated different parameters. Propolis has proven to be a good alternative for the treatment of gastric ulcer disease. However, future studies should be carried out to identify the compounds responsible for these effects and to determine their potential use in people.<\/jats:p>","DOI":"10.3390\/nu13093169","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T21:48:01Z","timestamp":1631483281000},"page":"3169","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Propolis and Its Gastroprotective Effects on NSAID-Induced Gastric Ulcer Disease: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5760-9955","authenticated-orcid":false,"given":"Porfirio Alonso","family":"Ruiz-Hurtado","sequence":"first","affiliation":[{"name":"Laboratorio de Toxicolog\u00eda de Productos Naturales, Departamento de Farmacia, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Ciencias Biol\u00f3gicas, Av. Wilfrido Massieu, Gustavo A. Madero, Ciudad de M\u00e9xico 07738, Mexico"},{"name":"Laboratorio de Investigaci\u00f3n Biom\u00e9dica en Productos Naturales, Carrera de Medicina, UNAM, FES-Iztacala, Avenida de los Barrios N\u00famero 1, Colonia Los Reyes Iztacala, Estado de M\u00e9xico 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2259-6322","authenticated-orcid":false,"given":"Leticia","family":"Gardu\u00f1o-Siciliano","sequence":"additional","affiliation":[{"name":"Laboratorio de Toxicolog\u00eda de Productos Naturales, Departamento de Farmacia, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Ciencias Biol\u00f3gicas, Av. Wilfrido Massieu, Gustavo A. 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Wilfrido Massieu, Gustavo A. Madero, Ciudad de M\u00e9xico 07738, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio","family":"Canales-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Biom\u00e9dica en Productos Naturales, Carrera de Medicina, UNAM, FES-Iztacala, Avenida de los Barrios N\u00famero 1, Colonia Los Reyes Iztacala, Estado de M\u00e9xico 54090, Mexico"},{"name":"Laboratorio de Gen\u00e9tica, Departamento de Farmacia, Instituto Polit\u00e9cnico Nacional, Escuela Nacional de Ciencias Biol\u00f3gicas, Av. Wilfrido Massieu, Gustavo A. Madero, Ciudad de M\u00e9xico 07738, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Margarita","family":"Canales-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio de Farmacognosia, UBIPRO, UNAM, FES-Iztacala, Avenida de los Barrios N\u00famero 1, Colonia Los Reyes Iztacala, Estado de M\u00e9xico 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6780-0710","authenticated-orcid":false,"given":"Marco Aurelio","family":"Rodr\u00edguez-Monroy","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Biom\u00e9dica en Productos Naturales, Carrera de Medicina, UNAM, FES-Iztacala, Avenida de los Barrios N\u00famero 1, Colonia Los Reyes Iztacala, Estado de M\u00e9xico 54090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/gut.49.3.443","article-title":"Cyclooxygenase 2\u2014Implications on maintenance of gastric mucosal integrity and ulcer healing: Controversial issues and perspectives","volume":"49","author":"Halter","year":"2001","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.3748\/wjg.v18.i18.2147","article-title":"Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility","volume":"18","author":"Takeuchi","year":"2012","journal-title":"World J. 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