{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:56:36Z","timestamp":1773474996625,"version":"3.50.1"},"reference-count":18,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003759","name":"Universidad Polit\u00e9cnica de Madrid","doi-asserted-by":"publisher","award":["none"],"award-info":[{"award-number":["none"]}],"id":[{"id":"10.13039\/501100003759","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>We sought to investigate the effects of resistance training (RT) combined with erythropoietin (EPO) and iron sulfate on the hemoglobin, hepcidin, ferritin, iron status, and inflammatory profile in older individuals with end-stage renal disease (ESRD). ESRD patients (n: 157; age: 66.8 \u00b1 3.6; body mass: 73 \u00b1 15; body mass index: 27 \u00b1 3), were assigned to control (CTL; n: 76) and exercise groups (RT; n: 81). The CTL group was divided according to the iron treatment received: without iron treatment (CTL\u2014none; n = 19), treated only with iron sulfate or EPO (CTL\u2014EPO or IRON; n = 19), and treated with both iron sulfate and EPO (CTL\u2014EPO + IRON; n = 76). The RT group followed the same pattern: (RT\u2014none; n = 20), (RT\u2014EPO or IRON; n = 18), and (RT\u2014EPO + IRON; n = 86). RT consisted of 24 weeks\/3 days per week at moderate intensity of full-body resistance exercises prior to the hemodialysis section. The RT group, regardless of the iron treatment, improved iron metabolism in older individuals with ESRD. These results provide some clues on the effects of RT and its combination with EPO and iron sulfate in this population, highlighting RT as an important coadjutant in ESRD-iron deficiency.<\/jats:p>","DOI":"10.3390\/nu13093250","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T22:34:01Z","timestamp":1632263641000},"page":"3250","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does the Combined Effect of Resistance Training with EPO and Iron Sulfate Improve Iron Metabolism in Older Individuals with End-Stage Renal Disease?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3080-9391","authenticated-orcid":false,"given":"Hugo de Luca","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Graduate Program of Physical Education, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-1222","authenticated-orcid":false,"given":"V\u00edctor Manuel","family":"Alfaro-Magallanes","sequence":"additional","affiliation":[{"name":"LFE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences (INEF), Universidad Polit\u00e9cnica de Madrid (UPM), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sting Ray Gouveia","family":"Moura","sequence":"additional","affiliation":[{"name":"Graduate Program of Physical Education, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Vanerson Passos","family":"Neves","sequence":"additional","affiliation":[{"name":"Graduate Program of Physical Education, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lysleine Alves","family":"Deus","sequence":"additional","affiliation":[{"name":"Graduate Program of Physical Education, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Sousa","family":"Honorato","sequence":"additional","affiliation":[{"name":"Graduate Program of Physical Education, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Lopes","family":"Silva","sequence":"additional","affiliation":[{"name":"Graduate Program of Physical Education, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3067-0545","authenticated-orcid":false,"given":"Artur Temizio Oppelt","family":"Raab","sequence":"additional","affiliation":[{"name":"Department of Medicine, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Carneiro Habbema","family":"Maia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela Akaishi","family":"Padula","sequence":"additional","affiliation":[{"name":"Department of Medicine, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Santos de","family":"Gusm\u00e3o Alves","sequence":"additional","affiliation":[{"name":"Department of Medicine, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafaela Ara\u00fajo","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Medicine, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-5626","authenticated-orcid":false,"given":"Andrea Lucena","family":"Reis","sequence":"additional","affiliation":[{"name":"Graduate Program of Physical Education, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonato","family":"Prestes","sequence":"additional","affiliation":[{"name":"Graduate Program of Physical Education, Catholic University of Brasilia, Federal District, Brasilia 71966-700, 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