{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:11:23Z","timestamp":1784394683288,"version":"3.55.0"},"reference-count":118,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017638","name":"Ministry of Health of the Russian Federation","doi-asserted-by":"publisher","award":["\u041d\u0418\u041e\u041a\u0422\u0420 \u0410\u0410\u0410\u0410-\u041019-119070490037-5"],"award-info":[{"award-number":["\u041d\u0418\u041e\u041a\u0422\u0420 \u0410\u0410\u0410\u0410-\u041019-119070490037-5"]}],"id":[{"id":"10.13039\/501100017638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Despite the progress in the development of new anticancer strategies, cancer is rapidly spreading around the world and remains one of the most common diseases. For more than 40 years, doxorubicin has been widely used in the treatment of solid and hematological tumors. At the same time, the problem of its cardiotoxicity remains unresolved, despite the high efficiency of this drug. Symptomatic therapy is used as a treatment for side-effects of doxorubicin or pathological conditions that have already appeared in their background. To date, there are no treatment methods for doxorubicin cardiomyopathy as such. A drug such as nicotinamide riboside can play an important role in solving this problem. Nicotinamide riboside is a pyridine nucleoside similar to vitamin B3 that acts as a precursor to NAD+. There is no published research on nicotinamide riboside effects on cardiomyopathy, despite the abundance of works devoted to the mechanisms of its effects in various pathologies. The review analyzes information about the effects of nicotinamide riboside on various experimental models of pathologies, its role in the synthesis of NAD+, and also considers the possibility and prospects of its use for the prevention of doxorubicin cardiomyopathy.<\/jats:p>","DOI":"10.3390\/nu13103435","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T21:38:09Z","timestamp":1632865089000},"page":"3435","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nicotinamide Riboside for the Prevention and Treatment of Doxorubicin Cardiomyopathy. Opportunities and Prospects"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-3301","authenticated-orcid":false,"given":"Ekaterina","family":"Podyacheva","sequence":"first","affiliation":[{"name":"Research Laboratory of Bioprosthetics and Cardiac Protection, Centre for Experimental Biomodeling, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Toropova","sequence":"additional","affiliation":[{"name":"Research Laboratory of Bioprosthetics and Cardiac Protection, Centre for Experimental Biomodeling, Almazov National Medical Research Centre, Ministry of Health of the Russian Federation, 197341 Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1200\/JCO.19.03141","article-title":"Clinical Cancer Advances 2020: Annual report on progress against cancer from the American Society of Clinical oncology","volume":"38","author":"Markham","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kleinerman, E.S. (2014). Current Advances in Osteosarcoma, Springer.","DOI":"10.1007\/978-3-319-04843-7"},{"key":"ref_4","first-page":"296","article-title":"Cardioprotective effect of melatonin and agomelatine on doxorubicin-induced cardiotoxicity in a rat model: An electrocardiographic, scintigraphic and biochemical study","volume":"116","author":"Gharagozloo","year":"2015","journal-title":"Bratisl. Lek. Listy."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2021.670479","article-title":"Analysis of Models of Doxorubicin-Induced Cardiomyopathy in Rats and Mice. A Modern View from the Perspective of the Pathophysiologist and the Clinician","volume":"12","author":"Podyacheva","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"ichiro NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR","volume":"27","author":"Yoshino","year":"2018","journal-title":"Cell Metab."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.celrep.2015.09.023","article-title":"Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart","volume":"13","author":"Xu","year":"2015","journal-title":"Cell Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.bbapap.2016.06.014","article-title":"NAD(+) metabolism: Bioenergetics, signaling and manipulation for therapy","volume":"1864","author":"Yang","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Menna, P., Gonzalez Paz, O., Chello, M., Covino, E., Salvatorelli, E., and Minotti, G. (2012). Anthracycline cardiotoxicity. Expert Opin. Drug Saf., 11.","DOI":"10.1517\/14740338.2011.589834"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nrm831","article-title":"Cellular roles of DNA topoisomerases: A molecular perspective","volume":"3","author":"Wang","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10557-016-6711-0","article-title":"Anthracycline Chemotherapy and Cardiotoxicity","volume":"31","author":"McGowan","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1126\/science.6093249","article-title":"Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II","volume":"226","author":"Tewey","year":"1984","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"dos Santos, D.S., and Goldenberg, R.C. (2018). Doxorubicin-Induced Cardiotoxicity: From Mechanisms to Development of Efficient Therapy. Cardiotoxicity, 3\u201324.","DOI":"10.5772\/intechopen.79588"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/nm.2919","article-title":"Identification of the molecular basis of doxorubicin-induced cardiotoxicity","volume":"18","author":"Zhang","year":"2012","journal-title":"Nat. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/pr.56.2.6","article-title":"Anthracyclines: Molecular advances and pharmacologie developments in antitumor activity and cardiotoxicity","volume":"56","author":"Minotti","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12012-007-0024-2","article-title":"Genotyping the risk of anthracycline-induced cardiotoxicity","volume":"7","author":"Deng","year":"2007","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejphar.2017.10.043","article-title":"Molecular Mechanism of Doxorubicin-Induced Cardiomyopathy\u2014An Update","volume":"818","author":"Renu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.yjmcc.2012.03.006","article-title":"Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies","volume":"52","author":"Octavia","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"8839","DOI":"10.1158\/0008-5472.CAN-07-1649","article-title":"Topoisomerase II\u03b2-mediated DNA double-strand breaks: Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane","volume":"67","author":"Yi","year":"2007","journal-title":"Cancer Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"12610","DOI":"10.1074\/jbc.271.21.12610","article-title":"Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic mice","volume":"271","author":"Chen","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1172\/JCI118909","article-title":"The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice","volume":"98","author":"Yen","year":"1996","journal-title":"J. Clin. Invest."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0092-8674(04)00416-7","article-title":"Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a preiss-handler independent route to NAD+ in fungi and humans","volume":"117","author":"Bieganowski","year":"2004","journal-title":"Cell"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.5925\/jnsv1954.14.Supplement_123","article-title":"NAD synthesis in animal tissues","volume":"14","author":"Dietrich","year":"1968","journal-title":"J. Vitaminol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Croft, T., Venkatakrishnan, P., and Lin, S.J. (2020). Nad+ metabolism and regulation: Lessons from yeast. Biomolecules, 10.","DOI":"10.3390\/biom10020330"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/ars.2017.7216","article-title":"NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism","volume":"28","author":"Xiao","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Hwang, E.S., and Song, S.B. (2020). Possible adverse effects of high-dose nicotinamide: Mechanisms and safety assessment. Biomolecules, 10.","DOI":"10.3390\/biom10050687"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2174\/138161209787185814","article-title":"Nicotinamide Phosphoribosyltransferase (Nampt): A Link Between NAD Biology, Metabolism, and Diseases","volume":"15","author":"Imai","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","article-title":"Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice","volume":"14","author":"Yoshino","year":"2011","journal-title":"Cell Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10522-013-9489-5","article-title":"Mapping NAD+ metabolism in the brain of ageing Wistar rats: Potential targets for influencing brain senescence","volume":"15","author":"Braidy","year":"2014","journal-title":"Biogerontology"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Mehmel, M., Jovanovi\u0107, N., and Spitz, U. (2020). Nicotinamide riboside\u2014the current state of research and therapeutic uses. Nutrients, 12.","DOI":"10.3390\/nu12061616"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Hopp, A.K., Gr\u00fcter, P., and Hottiger, M.O. (2019). Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation. Cells, 8.","DOI":"10.3390\/cells8080890"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms13103","article-title":"NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells","volume":"7","author":"Ratajczak","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1371\/journal.pbio.0050263","article-title":"Nicotinamide riboside kinase structures reveal new pathways to NAD+","volume":"5","author":"Tempel","year":"2007","journal-title":"PLoS Biol."},{"key":"ref_34","first-page":"1","article-title":"The Emergence of the Nicotinamide Riboside Kinases in the regulation of NAD+ Metabolism","volume":"44","author":"Fletcher","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms12948","article-title":"Nicotinamide riboside is uniquely and orally bioavailable in mice and humans","volume":"7","author":"Trammell","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.nutr.28.061807.155443","article-title":"Nicotinic acid, nicotinamide, and nicotinamide riboside: A molecular evaluation of NAD+ precursor vitamins in human nutrition","volume":"28","author":"Bogan","year":"2008","journal-title":"Annu. Rev. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1021\/jm701001c","article-title":"Syntheses of nicotinamide riboside and derivatives: Effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells","volume":"50","author":"Yang","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"27124","DOI":"10.1074\/jbc.M115.664458","article-title":"Generation, release, and uptake of the NAD precursor nicotinic acid riboside by human cells","volume":"290","author":"Kulikova","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.mam.2013.01.004","article-title":"Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes","volume":"34","author":"Sauve","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.cell.2014.06.050","article-title":"Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism","volume":"158","author":"Masri","year":"2014","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.cmet.2018.01.016","article-title":"The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications","volume":"27","author":"Carrico","year":"2018","journal-title":"Cell Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"19304","DOI":"10.1074\/jbc.M112.363747","article-title":"Nicotinamide-induced mitophagy: Event mediated by high NAD+\/NADH ratio and SIRT1 protein activation","volume":"287","author":"Jang","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cmet.2010.02.006","article-title":"Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle","volume":"11","author":"Jiang","year":"2010","journal-title":"Cell Metab."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cmet.2015.05.023","article-title":"NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus","volume":"22","author":"Menzies","year":"2015","journal-title":"Cell Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1124\/pr.110.003905","article-title":"Targeting sirtuin 1 to improve metabolism: All you need is NAD+?","volume":"64","author":"Auwerx","year":"2012","journal-title":"Pharmacol. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cmet.2007.07.003","article-title":"SIRT2 Regulates Adipocyte Differentiation through FoxO1 Acetylation\/Deacetylation","volume":"6","author":"Jing","year":"2007","journal-title":"Cell Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1242\/jcs.073783","article-title":"SIRT2 regulates NF-\u03baB-dependent gene expression through deacetylation of p65 Lys310","volume":"123","author":"Rothgiesser","year":"2010","journal-title":"J. Cell Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20120030","article-title":"SIRT3, a pivotal actor in mitochondrial functions: Metabolism, cell death and aging","volume":"444","author":"Giralt","year":"2012","journal-title":"Biochem. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1371\/journal.pbio.0040295","article-title":"Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic \u03b2 cells","volume":"4","author":"Bordone","year":"2006","journal-title":"PLoS Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature08778","article-title":"SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation","volume":"464","author":"Hirschey","year":"2010","journal-title":"Nature"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.1207861","article-title":"Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase","volume":"334","author":"Du","year":"2011","journal-title":"Science"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cell.2009.12.041","article-title":"The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1\u03b1","volume":"140","author":"Zhong","year":"2010","journal-title":"Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1101\/gad.1399706","article-title":"Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription","volume":"20","author":"Ford","year":"2006","journal-title":"Genes Dev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nature11043","article-title":"SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation","volume":"487","author":"Barber","year":"2012","journal-title":"Nature"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cmet.2012.06.016","article-title":"The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease","volume":"16","author":"Bai","year":"2012","journal-title":"Cell Metab."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.bcp.2011.12.014","article-title":"Cellular bioenergetics is regulated by PARP1 under resting conditions and during oxidative stress","volume":"83","author":"Szoleczky","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.cmet.2014.10.005","article-title":"A high-fat diet and NAD+ activate sirt1 to rescue premature aging in cockayne syndrome","volume":"20","author":"Mitchell","year":"2014","journal-title":"Cell Metab."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.cmet.2011.03.013","article-title":"PARP-2 regulates SIRT1 expression and whole-body energy expenditure","volume":"13","author":"Bai","year":"2011","journal-title":"Cell Metab."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1073\/pnas.1016574108","article-title":"Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression","volume":"108","author":"Boehler","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"28951","DOI":"10.1074\/jbc.M604370200","article-title":"Acidic residues at the active sites of CD38 and ADP-ribosylt cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities","volume":"281","author":"Graeff","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.imlet.2018.06.007","article-title":"CD157: From immunoregulatory protein to potential therapeutic target","volume":"205","author":"Ortolan","year":"2019","journal-title":"Immunol. Lett."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.bbrc.2006.05.042","article-title":"Regulation of intracellular levels of NAD: A novel role for CD38","volume":"345","author":"Aksoy","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2337\/db12-1139","article-title":"Flavonoid apigenin is an inhibitor of the NAD+ase CD38: Implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome","volume":"62","author":"Escande","year":"2013","journal-title":"Diabetes"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1074-7613(00)80353-2","article-title":"The CD38 lymphocyte differentiation marker: New insight into its ectoenzymatic activity and its role as a signal transducer","volume":"7","author":"Shubinsky","year":"1997","journal-title":"Immunity"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/cyto.b.21092","article-title":"CD38 and CD157: A long journey from activation markers to multifunctional molecules","volume":"84","author":"Quarona","year":"2013","journal-title":"Cytom. Part B\u2014Clin. Cytom."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4049\/jimmunol.160.1.395","article-title":"Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member","volume":"160","author":"Deaglio","year":"1998","journal-title":"J. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2119\/molmed.2009.00146","article-title":"CD38\/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells","volume":"16","author":"Deaglio","year":"2010","journal-title":"Mol. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.celrep.2018.03.071","article-title":"Sarm1\/Myd88-5 Regulates Neuronal Intrinsic Immune Response to Traumatic Axonal Injuries","volume":"23","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"19831","DOI":"10.1074\/jbc.REV119.009635","article-title":"Resolving the topological enigma in Ca2+ signaling by cyclic ADP-ribose and NAADP","volume":"294","author":"Lee","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bcp.2019.01.005","article-title":"SARM: From immune regulator to cell executioner","volume":"161","author":"Carty","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0019194","article-title":"Age related changes in NAD+ metabolism oxidative stress and sirt1 activity in wistar rats","volume":"6","author":"Braidy","year":"2011","journal-title":"PLoS ONE"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.cell.2013.11.037","article-title":"Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging","volume":"155","author":"Gomes","year":"2013","journal-title":"Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1474-9726.2007.00355.x","article-title":"Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice","volume":"7","author":"Ramsey","year":"2008","journal-title":"Aging Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Feige","year":"2009","journal-title":"Nature"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1101\/gad.1650608","article-title":"Tissue-specific regulation of SIRT1 by calorie restriction","volume":"22","author":"Chen","year":"2008","journal-title":"Genes Dev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.cmet.2014.04.001","article-title":"NAD+-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease","volume":"19","author":"Cerutti","year":"2014","journal-title":"Cell Metab."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/emmm.201403943","article-title":"Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3","volume":"6","author":"Khan","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tcb.2014.04.002","article-title":"NAD+ and sirtuins in aging and disease","volume":"24","author":"Imai","year":"2014","journal-title":"Trends Cell Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cell.2013.03.004","article-title":"Influence of metabolism on epigenetics and disease","volume":"153","author":"Kaelin","year":"2013","journal-title":"Cell"},{"key":"ref_81","first-page":"139","article-title":"NAD+ metabolism and the control of energy homeostasis\u2014A balancing act between mitochondria and the nucleus","volume":"176","author":"Bei","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2006.11.006","article-title":"NAD+ metabolism in health and disease","volume":"32","author":"Belenky","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhang, W., Huang, Q., Zeng, Z., Wu, J., Zhang, Y., and Chen, Z. (2017). Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells. Oxid. Med. Cell. Longev., 2017.","DOI":"10.1155\/2017\/7543973"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.phrs.2009.12.006","article-title":"Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation","volume":"62","author":"Yu","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"28873","DOI":"10.1074\/jbc.M401138200","article-title":"FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1","volume":"279","author":"Tertoolen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1161\/CIRCULATIONAHA.109.864629","article-title":"MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1","volume":"120","author":"Menghini","year":"2009","journal-title":"Circulation"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"e1827","DOI":"10.1038\/cddis.2015.193","article-title":"Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression","volume":"6","author":"Liu","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.cellsig.2013.06.007","article-title":"Antagonistic crosstalk between NF-\u03baB and SIRT1 in the regulation of inflammation and metabolic disorders","volume":"25","author":"Kauppinen","year":"2013","journal-title":"Cell. Signal."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.mam.2005.07.006","article-title":"Superoxide dismutases and their impact upon human health","volume":"26","author":"Johnson","year":"2005","journal-title":"Mol. Aspects Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.metabol.2013.12.011","article-title":"Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway","volume":"63","author":"Shimada","year":"2014","journal-title":"Metabolism"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/acel.12461","article-title":"Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice","volume":"15","author":"Gano","year":"2016","journal-title":"Aging Cell"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"10268","DOI":"10.1073\/pnas.1003833107","article-title":"Shear stress, SIRT1, and vascular homeostasis","volume":"107","author":"Chen","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cmet.2012.04.022","article-title":"The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity","volume":"15","author":"Houtkooper","year":"2012","journal-title":"Cell Metab."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.cmet.2014.11.003","article-title":"Activation of SIRT3 by the NAD+ precursor nicotinamide riboside protects from noise-induced hearing loss","volume":"20","author":"Brown","year":"2016","journal-title":"Cell Metab."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cmet.2016.07.005","article-title":"Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle","volume":"24","author":"Frederick","year":"2016","journal-title":"Cell Metab."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1126\/science.aaf2693","article-title":"NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice","volume":"352","author":"Zhang","year":"2016","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.neurobiolaging.2012.12.005","article-title":"Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-\u03b3 coactivator 1\u03b1 regulated \u03b2-secretase 1 degradation and mitochondrial gene expression in Alzheimer\u2019s mouse models","volume":"34","author":"Gong","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e201301012","DOI":"10.5936\/csbj.201301012","article-title":"Targeted, LCMS-based metabolomics for quantitative measurement of NAD+ metabolites","volume":"4","author":"Trammell","year":"2013","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep26933","article-title":"Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice","volume":"6","author":"Trammell","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3945\/jn.116.230078","article-title":"Nicotinamide riboside is a major NAD+ precursor vitamin in cow milk","volume":"146","author":"Trammell","year":"2016","journal-title":"J. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2018.05.073","article-title":"Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis","volume":"123","author":"Hong","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1042\/CS20181022","article-title":"Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity","volume":"133","author":"Zheng","year":"2019","journal-title":"Clin. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Zhang, X., Henneman, N.F., Girardot, P.E., Sellers, J.T., Chrenek, M.A., Li, Y., Wang, J., Brenner, C., Nickerson, J.M., and Boatright, J.H. (2020). Systemic Treatment with Nicotinamide Riboside Is Protective in a Mouse Model of Light-Induced Retinal Degeneration. Investig. Ophthalmol. Vis. Sci., 61.","DOI":"10.1167\/iovs.61.10.47"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/0960327115626254","article-title":"Safety assessment of nicotinamide riboside, a form of Vitamin B3","volume":"35","author":"Conze","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12970-016-0143-x","article-title":"The NAD+ precursor nicotinamide riboside decreases exercise performance in rats","volume":"13","author":"Kourtzidis","year":"2016","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1113\/EP086964","article-title":"Nicotinamide riboside supplementation dysregulates redox and energy metabolism in rats: Implications for exercise performance","volume":"103","author":"Kourtzidis","year":"2018","journal-title":"Exp. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1097\/j.pain.0000000000000862","article-title":"Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats","volume":"158","author":"Hamity","year":"2017","journal-title":"Pain"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/iep.12302","article-title":"Nicotinamide riboside has protective effects in a rat model of mesenteric ischaemia-reperfusion","volume":"99","author":"Toropova","year":"2018","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.1094637","article-title":"Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase","volume":"303","author":"Brunet","year":"2004","journal-title":"Science"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.stem.2008.01.002","article-title":"SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization","volume":"2","author":"Han","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.freeradbiomed.2009.03.011","article-title":"Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway","volume":"46","author":"Skramsted","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.RES.0000267723.65696.4a","article-title":"Sirt1 regulates aging and resistance to oxidative stress in the heart","volume":"100","author":"Alcendor","year":"2007","journal-title":"Circ. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.dnarep.2014.08.005","article-title":"The function of nicotinamide phosphoribosyltransferase in the heart","volume":"23","author":"Hsu","year":"2014","journal-title":"DNA Repair"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/CIRCRESAHA.113.301651","article-title":"Mechanisms of altered Ca2+ handling in heart failure","volume":"113","author":"Luo","year":"2013","journal-title":"Circ. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jacbts.2018.06.005","article-title":"Role of Endothelium in Doxorubicin-Induced Cardiomyopathy","volume":"3","author":"Luu","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"114019","DOI":"10.1016\/j.bcp.2020.114019","article-title":"Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside","volume":"178","author":"Mateuszuk","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.chembiol.2012.08.011","article-title":"Bacterial inactivation of the anticancer drug doxorubicin","volume":"19","author":"Westman","year":"2012","journal-title":"Chem. Biol."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Ma, W., Mao, Q., Xia, W., Dong, G., Yu, C., and Jiang, F. (2019). Gut microbiota shapes the efficiency of cancer therapy. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01050"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/10\/3435\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:06:24Z","timestamp":1760166384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/10\/3435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,28]]},"references-count":118,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["nu13103435"],"URL":"https:\/\/doi.org\/10.3390\/nu13103435","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-669612\/v1","asserted-by":"object"}]},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,28]]}}}