{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:57:17Z","timestamp":1760785037882,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diabetes is associated with a number of mental health consequences, including enhanced risk of depression and anxiety, as well as decreased quality of life, and vitamin D deficiency is considered to be one of the factors that influence these outcomes in diabetic patients. The aim of the present study was to conduct a systematic review of the literature presenting the data regarding the influence of vitamin D supplementation on mental health in diabetic adults. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (Registration number CRD42020155779). A systematic search of the PubMed and Web of Science databases was performed, and the intervention studies published until September 2021 were included in the review. The human studies were included if an adult sample of diabetic individuals received vitamin D supplementation during the intervention and its effect on any mental health aspect was assessed, but studies presenting the influence of combined supplementation of multiple nutrients were excluded. After removing duplicate records, a total of 8514 publications were screened and assessed independently by two researchers, based on their title, abstract, and full text. Finally, six studies were included in the current systematic review, and the risk of bias was evaluated using the Newcastle\u2013Ottawa Scale (NOS). The included studies analyzed the influence of a specific dose of vitamin D, or different doses of vitamin D, or compared the results of supplementation with a specific dose of vitamin D against the placebo group. The supplementation was performed for at least 12 weeks. The mental health outcomes analyzed in these studies included health-related quality of life, depression, anxiety, stress, and general mental health status of adult diabetic patients. The results of the majority of the studies confirmed the positive influence of vitamin D supplementation on the mental health of diabetic individuals. Those studies that analyzed the influence of vitamin D supplementation on depression and anxiety established the beneficial effect of the vitamin. In some studies, the influence of vitamin D supplementation on the health-related quality of life was not considered unless combined with mindfulness training. However, it must be emphasized that different dosage regimens and intervention periods were followed in the reviewed studies, and only a small number of studies were randomized against placebo, which should be considered as a limitation of the present study. The findings of the conducted systematic review demonstrated the positive influence of vitamin D supplementation on the mental health of diabetic patients, which was proved for anxiety and depression, but in the case of health-related quality of life, the positive effect was observed only when the intervention included mindfulness training. These outcomes suggest that supplementation should be recommended to improve the vitamin D status and the mental health of patients in this group.<\/jats:p>","DOI":"10.3390\/nu13113678","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T21:31:26Z","timestamp":1634765486000},"page":"3678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0784-3604","authenticated-orcid":false,"given":"Dominika","family":"Guzek","sequence":"first","affiliation":[{"name":"Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-6049","authenticated-orcid":false,"given":"Aleksandra","family":"Ko\u0142ota","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-2587","authenticated-orcid":false,"given":"Katarzyna","family":"Lachowicz","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5818-9884","authenticated-orcid":false,"given":"Dominika","family":"Skolmowska","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Stacho\u0144","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8588-7357","authenticated-orcid":false,"given":"Dominika","family":"G\u0142\u0105bska","sequence":"additional","affiliation":[{"name":"Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), 159C Nowoursynowska Street, 02-776 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2010). Diagnosis and classification of diabetes mellitus. Diabetes Care, 33, S62\u2013S69.","DOI":"10.2337\/dc10-S062"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"14790","DOI":"10.1038\/s41598-020-71908-9","article-title":"Global, regional, and national burden and trend of diabetes in 195 countries and territories: An analysis from 1990 to 2025","volume":"10","author":"Lin","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_3","unstructured":"World Health Organization (WHO) (2021, September 14). Global NCD Target Halt the Rise in Diabetes. Available online: https:\/\/www.who.int\/beat-ncds\/take-action\/policy-brief-halt-diabetes.pdf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100822","DOI":"10.1016\/j.pmedr.2019.100822","article-title":"Diabetes increases the risk of depression: A systematic review, meta-analysis and estimates of population attributable fractions based on prospective studies","volume":"14","author":"Chireh","year":"2019","journal-title":"Prev. Med. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.diabres.2012.11.022","article-title":"Diabetes mellitus as a risk factor for depression. A meta-analysis of longitudinal studies","volume":"99","author":"Rotella","year":"2013","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jpsychores.2012.11.013","article-title":"Association of diabetes with anxiety: A systematic review and meta-analysis","volume":"74","author":"Smith","year":"2013","journal-title":"J. Psychosom. Res."},{"key":"ref_7","first-page":"91217419837407","article-title":"Diabetes and anxiety symptoms: A systematic review and meta-analysis","volume":"2","author":"Amiri","year":"2019","journal-title":"Int. J. Psychiatry Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"5419298","DOI":"10.1155\/2020\/5419298","article-title":"Measuring the Quality of Life in Diabetic Patients: A Scoping Review","volume":"2020","author":"Palamenghi","year":"2020","journal-title":"J. Diabetes Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12955-018-1021-9","article-title":"Related factors of quality of life of type 2 diabetes patients: A systematic review and meta-analysis","volume":"16","author":"Jing","year":"2018","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/S0140-6736(14)60613-9","article-title":"Prevention and management of type 2 diabetes: Dietary components and nutritional strategies","volume":"383","author":"Ley","year":"2014","journal-title":"Lancet"},{"key":"ref_11","unstructured":"Feingold, K.R., Anawalt, B., Boyce, A., Chrousos, G., de Herder, W.W., Dhatariya, K., Dungan, K., Grossman, A., Hershman, J.M., and Hofland, J. (2021, September 14). Nutritional Recommendations for Individuals with Diabetes, Endotext [Internet], Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279012\/."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/pgmj.2009.078626","article-title":"Vitamin D deficiency and type 2 diabetes","volume":"86","author":"Ozfirat","year":"2010","journal-title":"Postgrad. Med. J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Luo, B.A., Gao, F., and Qin, L.L. (2017). The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies. Nutrients, 9.","DOI":"10.3390\/nu9030307"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12955-018-0873-3","article-title":"Vitamin D deficiency is associated with poorer satisfaction with diabetes-related treatment and quality of life in patients with type 2 diabetes: A cross-sectional study","volume":"16","author":"Alcubierre","year":"2018","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4103\/jpgm.JPGM_571_17","article-title":"Efficacy of vitamin D supplementation in major depression: A meta-analysis of randomized controlled trials","volume":"65","author":"Vellekkatt","year":"2019","journal-title":"J. Postgrad. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/PSY.0000000000000044","article-title":"Vitamin D supplementation for depressive symptoms: A systematic review and meta-analysis of randomized controlled trials","volume":"76","author":"Shaffer","year":"2014","journal-title":"Psychosom. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3390\/nu6041501","article-title":"Vitamin D and depression: A systematic review and meta-analysis comparing studies with and without biological flaws","volume":"6","author":"Spedding","year":"2014","journal-title":"Nutrients"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/da.23025","article-title":"The effect of vitamin D supplement on negative emotions: A systematic review and meta-analysis","volume":"37","author":"Cheng","year":"2020","journal-title":"Depress. Anxiety"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jand.2014.10.023","article-title":"Vitamin D supplementation and health-related quality of life: A systematic review of the literature","volume":"115","author":"Hoffmann","year":"2015","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_20","unstructured":"PROSPERO (2021, October 09). International Prospective Register of Systematic Reviews. Available online: https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=155779."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"G\u0142\u0105bska, D., Ko\u0142ota, A., Lachowicz, K., Skolmowska, D., Stacho\u0144, M., and Guzek, D. (2021). The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review. Nutrients, 13.","DOI":"10.3390\/nu13030952"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., and PRISMA Group (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref_23","unstructured":"(2021, July 28). Assessing Risk of Bias in Non-Randomized Studies. Chapter 13.5.2.3. Available online: http:\/\/handbook-5-1.cochrane.org\/."},{"key":"ref_24","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2021, October 09). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Available online: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"You, S., Kong, T.H., and Han, W. (2020). The Effects of short-term and long-term hearing changes on music exposure: A systematic review and meta-analysis. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17062091"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1530\/EC-16-0070","article-title":"Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus","volume":"5","author":"Westra","year":"2016","journal-title":"Endocr. Connect."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.clnu.2016.05.012","article-title":"Vitamin D3 supplementation, bone health and quality of life in adults with diabetes and chronic kidney disease: Results of an open label randomized clinical trial","volume":"36","author":"Mager","year":"2017","journal-title":"Clin. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8232863","DOI":"10.1155\/2017\/8232863","article-title":"Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes","volume":"2017","author":"Penckofer","year":"2017","journal-title":"J. Diabetes Res."},{"key":"ref_29","first-page":"17","article-title":"Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women with Anxiety: A Randomized Clinical Trial","volume":"12","author":"Fazelian","year":"2019","journal-title":"Int. J. Prev. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.dsx.2019.06.011","article-title":"Effects of vitamin D supplementation on depressive symptoms in type 2 diabetes mellitus patients: Randomized placebo-controlled double-blind clinical trial","volume":"13","author":"Omidian","year":"2019","journal-title":"Diabetes Metab. Syndr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s40200-020-00700-3","article-title":"The synergistic effect of vitamin D supplement and mindfulness training on pain severity, pain-related disability and neuropathy-specific quality of life dimensions in painful diabetic neuropathy: A randomized clinical trial with placebo-controlled","volume":"20","author":"Davoudi","year":"2021","journal-title":"J. Diabetes Metab. Disord."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00198-007-0465-2","article-title":"Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents","volume":"19","author":"Chel","year":"2008","journal-title":"Osteoporos. Int."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"De Niet, S., Coffiner, M., Da Silva, S., Jandrain, B., Souberbielle, J.C., and Cavalier, E. (2018). A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D3; Supplementation. Nutrients, 10.","DOI":"10.3390\/nu10060659"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Dalle Carbonare, L., Valenti, M.T., Del Forno, F., Caneva, E., and Pietrobelli, A. (2017). Vitamin D: Daily vs. Monthly Use in Children and Elderly-What Is Going On?. Nutrients, 9.","DOI":"10.3390\/nu9070652"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.31887\/DCNS.2014.16.2\/drevicki","article-title":"A history of health-related quality of life outcomes in psychiatry","volume":"16","author":"Revicki","year":"2014","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4239\/wjd.v8.i4.120","article-title":"Type 2 diabetes and quality of life","volume":"8","author":"Trikkalinou","year":"2017","journal-title":"World J. Diabetes."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/02813430510015296","article-title":"Quality of life of patients with diabetes mellitus. An overview of research in primary health care in the Nordic countries","volume":"23","year":"2005","journal-title":"Scand. J. Prim. Health Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.cpr.2011.04.006","article-title":"Effects of mindfulness on psychological health: A review of empirical studies","volume":"31","author":"Keng","year":"2011","journal-title":"Clin. Psychol. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"258","DOI":"10.5993\/AJHB.40.2.11","article-title":"Associations of Mindfulness with Glucose Regulation and Diabetes","volume":"40","author":"Loucks","year":"2016","journal-title":"Am. J. Health Behav."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2147\/DMSO.S106797","article-title":"Depression in people with type 2 diabetes: Current perspectives","volume":"11","author":"Darwish","year":"2018","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1758-5996-2-72","article-title":"Anxiety and depression among outpatients with type 2 diabetes: A multi-centre study of prevalence and associated factors","volume":"2","author":"Khuwaja","year":"2010","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Tovote, K.A., Fleer, J., Snippe, E., Bas, I.V., Links, T.P., Emmelkamp, P.M., Sanderman, R., and Schroevers, M.J. (2013). Cognitive behavioral therapy and mindfulness-based cognitive therapy for depressive symptoms in patients with diabetes: Design of a randomized controlled trial. BMC Psychol., 1.","DOI":"10.1186\/2050-7283-1-17"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1037\/a0027666","article-title":"Major depression can be prevented","volume":"67","author":"Beardslee","year":"2012","journal-title":"Am. Psychol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1753-4887.2009.00220.x","article-title":"Vitamin D and the occurrence of depression: Causal association or circumstantial evidence?","volume":"67","year":"2009","journal-title":"Nutr. Rev."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/11\/3678\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:19:11Z","timestamp":1760167151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/11\/3678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,20]]},"references-count":44,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["nu13113678"],"URL":"https:\/\/doi.org\/10.3390\/nu13113678","relation":{},"ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"subject":[],"published":{"date-parts":[[2021,10,20]]}}}