{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:45:42Z","timestamp":1785894342846,"version":"3.56.0"},"reference-count":42,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Servier (France)","award":["CT0069291-01"],"award-info":[{"award-number":["CT0069291-01"]}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DEQ-20170336743"],"award-info":[{"award-number":["DEQ-20170336743"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Pectin, a soluble fiber, improves non-alcoholic fatty-liver disease (NAFLD), but its mechanisms are unclear. We aimed to investigate the role of pectin-induced changes in intestinal microbiota (IM) in NAFLD. We recovered the IM from mice fed a high-fat diet, treated or not with pectin, to perform a fecal microbiota transfer (FMT). Mice fed a high-fat diet, which induces NAFLD, were treated with pectin or received a fecal microbiota transfer (FMT) from mice treated with pectin before (preventive FMT) or after (curative FMT) being fed a high-fat diet. Pectin prevented the development of NAFLD, induced browning of adipose tissue, and modified the IM without increasing the abundance of proteobacteria. Preventive FMT also induced browning of white adipose tissue but did not improve liver steatosis, in contrast to curative FMT, which induced an improvement in steatosis. This was associated with an increase in the concentration of short-chain fatty acids (SCFAs), in contrast to preventive FMT, which induced an increase in the concentration of branched SCFAs. Overall, we show that the effect of pectin may be partially mediated by gut bacteria.<\/jats:p>","DOI":"10.3390\/nu13113725","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T22:07:11Z","timestamp":1635113231000},"page":"3725","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice"],"prefix":"10.3390","volume":"13","author":[{"given":"Camille","family":"Houron","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm U996, Inflammation, Microbiome and Immunosurveillance, 32 rue des carnets, 92140 Clamart, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragos","family":"Ciocan","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm U996, Inflammation, Microbiome and Immunosurveillance, 32 rue des carnets, 92140 Clamart, France"},{"name":"AP-HP, Hepato-Gastroenterology and Nutrition, H\u00f4pital Antoine-B\u00e9cl\u00e8re, 92140 Clamart, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Trainel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm U996, Inflammation, Microbiome and Immunosurveillance, 32 rue des carnets, 92140 Clamart, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Mercier-Nom\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, CNRS, Institut Paris Saclay d\u2019Innovation Th\u00e9rapeutique, 5 rue J.B. 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