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Although this clinical observation could be the mere coincidence of frequent age-dependent disorders, clinical and experimental data suggest that VC and bone loss could share pathophysiological mechanisms. Indeed, VC is an active process of calcium and phosphate precipitation that involves the transition of the vascular smooth muscle cells (VSMCs) into osteoblast-like cells. Among the molecules involved in this process, parathyroid hormone (PTH) plays a key role acting through several mechanisms which includes the regulation of the RANK\/RANKL\/OPG system and the Wnt\/\u00df-catenin pathway, the main pathways for bone resorption and bone formation, respectively. Furthermore, some microRNAs have been implicated as common regulators of bone metabolism, VC, left ventricle hypertrophy and myocardial fibrosis. Elucidating the common mechanisms between ageing; VC and bone loss could help to better understand the potential effects of osteoporosis drugs on the CV system.<\/jats:p>","DOI":"10.3390\/nu13113835","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T23:24:42Z","timestamp":1635377082000},"page":"3835","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?"],"prefix":"10.3390","volume":"13","author":[{"given":"Jorge B.","family":"Cannata-And\u00eda","sequence":"first","affiliation":[{"name":"Bone and Mineral Research Unit, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Carrillo-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo D.","family":"Messina","sequence":"additional","affiliation":[{"name":"Investigaciones Reumatol\u00f3gicas y Osteol\u00f3gicas (IRO), Buenos Aires 1114, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-2788","authenticated-orcid":false,"given":"Neveen A. T.","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Center for Bone Quality, Division Endocrinology, Department of Medicine, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Panizo","sequence":"additional","affiliation":[{"name":"Bone and Mineral Research Unit, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge L.","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Service and Laboratory of Bone Diseases, Department of Medicine, Faculty of Medicine, Geneva University Hospital, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the International Osteoporosis Foundation (IOF) Working Group on Bone and Cardiovascular Diseases","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0169-6009(92)90925-4","article-title":"Osteoporosis and calcification of the aorta","volume":"19","author":"Frye","year":"1992","journal-title":"Bone Miner."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF02390833","article-title":"Bone loss and the progression of abdominal aortic calcification over a 25 year period: The Framingham heart study","volume":"68","author":"Kiel","year":"2001","journal-title":"Calcif. 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