{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:49Z","timestamp":1787029189362,"version":"build-2736575974"},"reference-count":63,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SU922\/1\u20131, WO1425\/6\u20131, DZ 78\/1\u20131"],"award-info":[{"award-number":["SU922\/1\u20131, WO1425\/6\u20131, DZ 78\/1\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Patients in the neurological ICU are at risk of suffering from disorders of the upper gastrointestinal tract. Oropharyngeal dysphagia (OD) can be caused by the underlying neurological disease and\/or ICU treatment itself. The latter was also identified as a risk factor for gastrointestinal dysmotility. However, its association with OD and the impact of the neurological condition is unclear. Here, we investigated a possible link between OD and gastric residual volume (GRV) in patients in the neurological ICU. In this retrospective single-center study, patients with an episode of mechanical ventilation (MV) admitted to the neurological ICU due to an acute neurological disease or acute deterioration of a chronic neurological condition from 2011\u20132017 were included. The patients were submitted to an endoscopic swallowing evaluation within 72 h of the completion of MV. Their GRV was assessed daily. Patients with \u22651 d of GRV \u2265500 mL were compared to all the other patients. Regression analysis was performed to identify the predictors of GRV \u2265500 mL\/d. With respect to GRV, the groups were compared depending on their FEES scores (0\u20133). A total of 976 patients were included in this study. A total of 35% demonstrated a GRV of \u2265500 mL\/d at least once. The significant predictors of relevant GRV were age, male gender, infratentorial or hemorrhagic stroke, prolonged MV and poor swallowing function. The patients with the poorest swallowing function presented a GRV of \u2265500 mL\/d significantly more often than the patients who scored the best. Conclusions: Our findings indicate an association between dysphagia severity and delayed gastric emptying in critically ill neurologic patients. This may partly be due to lesions in the swallowing and gastric network.<\/jats:p>","DOI":"10.3390\/nu13113879","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:24:22Z","timestamp":1635805462000},"page":"3879","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oropharyngeal Dysphagia and Impaired Motility of the Upper Gastrointestinal Tract\u2014Is There a Clinical Link in Neurocritical Care?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0865-0297","authenticated-orcid":false,"given":"Paul","family":"Muhle","sequence":"first","affiliation":[{"name":"Department of Neurology with Institute for Translational Neurology, Albert-Schweitzer-Campus, 1 A, University Hospital Muenster, 48149 Muenster, Germany"},{"name":"Institute for Biomagnetism and Biosignalanalysis, University Hospital Muenster, Malmedyweg 15, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Konert","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute for Translational Neurology, Albert-Schweitzer-Campus, 1 A, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Suntrup-Krueger","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute for Translational Neurology, Albert-Schweitzer-Campus, 1 A, University Hospital Muenster, 48149 Muenster, Germany"},{"name":"Institute for Biomagnetism and Biosignalanalysis, University Hospital Muenster, Malmedyweg 15, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Claus","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute for Translational Neurology, Albert-Schweitzer-Campus, 1 A, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bendix","family":"Labeit","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute for Translational Neurology, Albert-Schweitzer-Campus, 1 A, University Hospital Muenster, 48149 Muenster, Germany"},{"name":"Institute for Biomagnetism and Biosignalanalysis, University Hospital Muenster, Malmedyweg 15, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine I, School of Medicine, Fujita Health University, Toyoake 470-1192, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8979-5900","authenticated-orcid":false,"given":"Tobias","family":"Warnecke","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute for Translational Neurology, Albert-Schweitzer-Campus, 1 A, University Hospital Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Wirth","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Marien Hospital Herne, University Hospital Ruhr-Universit\u00e4t Bochum, 44625 Herne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Dziewas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Klinikum Osnabr\u00fcck, Am Finkenh\u00fcgel 1, 49076 Osnabr\u00fcck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.2214\/ajr.154.5.2108569","article-title":"Physiology and radiology of the normal oral and pharyngeal phases of swallowing","volume":"154","author":"Dodds","year":"1990","journal-title":"AJR Am. 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