{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:58:23Z","timestamp":1790614703976,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Post-acute consequences of COVID-19, also termed long COVID, include signs and symptoms persisting for more than 12 weeks with prolonged multisystem involvement; most often, however, malnutrition is ignored. Method: The objective was to analyze persistent symptoms, nutritional status, the evolution of muscle strength and performance status (PS) at 6 months post-discharge in a cohort of COVID-19 survivors. Results: Of 549 consecutive patients hospitalized for COVID-19 between 1 March and 29 April 2020, 23.7% died and 288 patients were at home at D30 post-discharge. At this date, 136 of them (47.2%) presented persistent malnutrition, a significant decrease in muscle strength or a PS \u2265 2. These patients received dietary counseling, nutritional supplementation, adapted physical activity guidance or physiotherapy assistance, or were admitted to post-care facilities. At 6 months post-discharge, 91.0% of the 136 patients (n = 119) were evaluated and 36.0% had persistent malnutrition, 14.3% complained of a significant decrease in muscle strength and 14.9% had a performance status &gt; 2. Obesity was more frequent in patients with impairment than in those without (52.8% vs. 31.0%; p = 0.0071), with these patients being admitted more frequently to ICUs (50.9% vs. 31.3%; p = 0.010). Among those with persistent symptoms, 10% had psychiatric co-morbidities (mood disorders, anxiety, or post-traumatic stress syndrome), 7.6% had prolonged pneumological symptoms and 4.2% had neurological symptoms. Conclusions: Obese subjects as well as patients who have stayed in intensive care have a higher risk of functional loss or undernutrition 6 months after a severe COVID infection. Malnutrition and loss of muscle strength should be considered in the clinical assessment of these patients.<\/jats:p>","DOI":"10.3390\/nu13113964","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T20:42:54Z","timestamp":1636317774000},"page":"3964","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Long-Term Evolution of Malnutrition and Loss of Muscle Strength after COVID-19: A Major and Neglected Component of Long COVID-19"],"prefix":"10.3390","volume":"13","author":[{"given":"Marine","family":"G\u00e9rard","sequence":"first","affiliation":[{"name":"Transversal Nutrition Unit, University of Lorraine, Nancy University Hospital, 54500 Vandoeuvre-les-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meliha","family":"Mahmutovic","sequence":"additional","affiliation":[{"name":"Transversal Nutrition Unit, University of Lorraine, Nancy University Hospital, 54500 Vandoeuvre-les-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Malgras","sequence":"additional","affiliation":[{"name":"Transversal Nutrition Unit, University of Lorraine, Nancy University Hospital, 54500 Vandoeuvre-les-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0538-1581","authenticated-orcid":false,"given":"Niasha","family":"Michot","sequence":"additional","affiliation":[{"name":"Transversal Nutrition Unit, University of Lorraine, Nancy University Hospital, 54500 Vandoeuvre-les-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Scheyer","sequence":"additional","affiliation":[{"name":"Transversal Nutrition Unit, University of Lorraine, Nancy University Hospital, 54500 Vandoeuvre-les-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Jaussaud","sequence":"additional","affiliation":[{"name":"Internal Medicine and Clinical Immunology Department, University of Lorraine, Nancy University Hospital, 54500 Vandoeuvre-les-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1369-6081","authenticated-orcid":false,"given":"Phi-Linh","family":"Nguyen-Thi","sequence":"additional","affiliation":[{"name":"Medical Evaluation Department, Department of Clinical Research Support PARC, University of Lorraine, Nancy University Hospital, 54500 Vandoeuvre-les-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-9856","authenticated-orcid":false,"given":"Didier","family":"Quilliot","sequence":"additional","affiliation":[{"name":"Transversal Nutrition Unit, University of Lorraine, Nancy University Hospital, 54500 Vandoeuvre-les-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1017\/S0950268821000145","article-title":"Surviving COVID-19 in Bergamo province: A post-acute outpatient re-evaluation","volume":"149","author":"Venturelli","year":"2021","journal-title":"Epidemiol. Infect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.clnesp.2021.03.002","article-title":"Prevalence and outcomes of malnutrition among hospitalized COVID-19 patients: A systematic review and meta-analysis","volume":"43","author":"Abate","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/jcsm.12674","article-title":"Weight loss, malnutrition, and cachexia in COVID-19: Facts and numbers","volume":"12","author":"Anker","year":"2021","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/jgh.15323","article-title":"Digestive system manifestations and clinical significance of coronavirus disease 2019: A systematic literature review","volume":"36","author":"Ye","year":"2021","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_5","first-page":"S261","article-title":"Feeding intolerance in critically ill patients with COVID-19","volume":"29","author":"Liu","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/0194599820926473","article-title":"The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis","volume":"163","author":"Tong","year":"2020","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00702-018-1862-8","article-title":"Flavor perception and the risk of malnutrition in patients with Parkinson\u2019s disease","volume":"125","author":"Roos","year":"2018","journal-title":"J. Neural Transm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41430-020-0642-3","article-title":"Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China","volume":"74","author":"Li","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"668","DOI":"10.14336\/AD.2020.0502","article-title":"Comorbid Chronic Diseases are Strongly Correlated with Disease Severity among COVID-19 Patients: A Systematic Review and Meta-Analysis","volume":"11","author":"Liu","year":"2020","journal-title":"Aging Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1007\/s40520-021-01942-8","article-title":"Post-COVID-19 acute sarcopenia: Physiopathology and management","volume":"33","author":"Piotrowicz","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Wong, D.W.L., Klinkhammer, B.M., Djudjaj, S., Villwock, S., Timm, M.C., Buhl, E.M., Wucherpfennig, S., Cacchi, C., Braunschweig, T., and Knuchel-Clarke, R. (2021). Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients. Cells, 10.","DOI":"10.1101\/2021.06.03.21258241"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2020.06.006","article-title":"The neurological insights of the emerging coronaviruses","volume":"78","author":"Msigwa","year":"2020","journal-title":"J. Clin. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Cereda, E., Clave, P., Collins, P.F., Holdoway, A., and Wischmeyer, P.E. (2021). Recovery Focused Nutritional Therapy across the Continuum of Care: Learning from COVID-19. Nutrients, 13.","DOI":"10.3390\/nu13093293"},{"key":"ref_15","first-page":"ciab611","article-title":"Persistent symptoms in adult patients one year after COVID-19: A prospective cohort study","volume":"5","author":"Seessle","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_16","first-page":"S2213-2600","article-title":"The long-term sequelae of COVID-19: An international consensus on research priorities for patients with pre-existing and new-onset airways disease","volume":"17","author":"Adeloye","year":"2021","journal-title":"Lancet Respir. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e048948","DOI":"10.1136\/bmjopen-2021-048948","article-title":"Impact of severe SARS-CoV-2 infection on nutritional status and subjective functional loss in a prospective cohort of COVID-19 survivors","volume":"11","author":"Quilliot","year":"2021","journal-title":"BMJ Open"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"726","DOI":"10.7326\/M20-1301","article-title":"Diagnostic Testing for Severe Acute Respiratory Syndrome-Related Coronavirus 2: A Narrative Review","volume":"172","author":"Cheng","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/art.22611","article-title":"Measuring fatigue in rheumatoid arthritis: A systematic review of scales in use","volume":"57","author":"Hewlett","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_20","first-page":"7","article-title":"Recommended respiratory disease questionnaires for use with adults and children in epidemiologlcal research","volume":"118","author":"Society","year":"1978","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","article-title":"Toxicity and response criteria of the Eastern Cooperative Oncology Group","volume":"5","author":"Oken","year":"1982","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_22","unstructured":"(2021, July 20). American Psychiatric Association: DSM-V Development. Available online: https:\/\/www.psychiatry.org\/psychiatrists\/practice\/dsm\/updates-to-dsm-5\/\/updates-to-dsm-5-criteria-text."},{"key":"ref_23","unstructured":"Arlington, V.A.P.A. (2013). Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association. [5th ed.]."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.clnu.2009.01.003","article-title":"Use of 10-point analogue scales to estimate dietary intake: A prospective study in patients nutritionally at-risk","volume":"28","author":"Thibault","year":"2009","journal-title":"Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"Craig","year":"2003","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clnu.2018.08.002","article-title":"GLIM criteria for the diagnosis of malnutrition\u2014A consensus report from the global clinical nutrition community","volume":"38","author":"Cederholm","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_27","unstructured":"HAS (2021, July 20). Diagnostic de la D\u00e9nutrition de l\u2019Enfant et de l\u2019Adulte. Saint-Denis La Plaine. Available online: https:\/\/www.has-sante.fr\/upload\/docs\/application\/pdf\/2019-11\/reco277_recommandations_rbp_denutrition_cd_2019_11_13_v0.pdf."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.nupar.2020.03.001","article-title":"Nutritional care at hospital during the Covid-19 viral epidemic: Expert opinion from the French-speaking Society for Clinical Nutrition and Metabolism (SFNCM)","volume":"34","author":"Thibault","year":"2020","journal-title":"Nut. Clin. M\u00e9tab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.clnesp.2021.07.020","article-title":"Prevalence of nutritional risk and malnutrition during and after hospitalization for COVID-19 infection: Preliminary results of a single-centre experience","volume":"45","author":"Fiorindi","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.clnu.2015.03.001","article-title":"Diagnostic criteria for malnutrition\u2014An ESPEN Consensus Statement","volume":"34","author":"Cederholm","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1172\/JCI114980","article-title":"Obesity and the metabolic response to severe multiple trauma in man","volume":"87","author":"Jeevanandam","year":"1991","journal-title":"J. Clin. Invest."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Gualtieri, P., Falcone, C., Romano, L., Macheda, S., Correale, P., Arciello, P., Polimeni, N., and Lorenzo, A. (2020). Body Composition Findings by Computed Tomography in SARS-CoV-2 Patients: Increased Risk of Muscle Wasting in Obesity. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21134670"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhang, X., Xie, X., Dou, Q., Liu, C., Zhang, W., Yang, Y., Deng, R., and Cheng, A.S.K. (2019). Association of sarcopenic obesity with the risk of all-cause mortality among adults over a broad range of different settings: A updated meta-analysis. BMC Geriatr., 19.","DOI":"10.1186\/s12877-019-1195-y"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"14974","DOI":"10.1038\/s41598-021-94138-z","article-title":"Long-term effects of malnutrition on severity of COVID-19","volume":"11","author":"Kurtz","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_35","first-page":"S261","article-title":"Nutritional parameters associated with prognosis in non-critically ill hospitalized COVID-19 patients: The NUTRI-COVID19 study","volume":"25","author":"Caccialanza","year":"2021","journal-title":"Clin. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jamainternmed.2020.0994","article-title":"Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China","volume":"180","author":"Wu","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-020-2521-4","article-title":"Factors associated with COVID-19-related death using OpenSAFELY","volume":"584","author":"Williamson","year":"2020","journal-title":"Nature"},{"key":"ref_38","first-page":"1","article-title":"Neurological manifestations of COVID-19: A systematic review and detailed comprehension","volume":"27","author":"Ousseiran","year":"2021","journal-title":"Int. J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Majolo, F., Silva, G.L.D., Vieira, L., Anli, C., Timmers, L., Laufer, S., and Goettert, M.I. (2021). Neuropsychiatric Disorders and COVID-19: What We Know So Far. Pharmaceuticals, 14.","DOI":"10.3390\/ph14090933"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.clnu.2020.04.042","article-title":"A visual analogue scale for food intake as a screening test for malnutrition in the primary care setting: Prospective non-interventional study","volume":"40","author":"Bouette","year":"2020","journal-title":"Clin. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/11\/3964\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:26:57Z","timestamp":1760167617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/11\/3964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,6]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["nu13113964"],"URL":"https:\/\/doi.org\/10.3390\/nu13113964","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,6]]}}}