{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:17:19Z","timestamp":1791501439474,"version":"4.3.4"},"reference-count":65,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1024739"],"award-info":[{"award-number":["GNT1024739"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1057608"],"award-info":[{"award-number":["GNT1057608"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1041789"],"award-info":[{"award-number":["GNT1041789"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001026","name":"National Breast Cancer Foundation","doi-asserted-by":"publisher","award":["ECF-13-09"],"award-info":[{"award-number":["ECF-13-09"]}],"id":[{"id":"10.13039\/501100001026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["CRP-19-175-06-COUN"],"award-info":[{"award-number":["CRP-19-175-06-COUN"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Limited evidence exists on the effects of weight loss on chronic disease risk and patient-reported outcomes in breast cancer survivors. Breast cancer survivors (stage I\u2013III; body mass index 25\u201345 kg\/m2) were randomized to a 12-month, remotely delivered (22 telephone calls, mailed material, optional text messages) weight loss (diet and physical activity) intervention (n = 79) or usual care (n = 80). Weight loss (primary outcome), body composition, metabolic syndrome risk score and components, quality of life, fatigue, musculoskeletal pain, menopausal symptoms, fear of recurrence, and body image were assessed at baseline, 6 months, 12 months (primary endpoint), and 18 months. Participants were 55 \u00b1 9 years and 10.7 \u00b1 5.0 months post-diagnosis; retention was 81.8% (12 months) and 80.5% (18 months). At 12-months, intervention participants had significantly greater improvements in weight (\u22124.5% [95%CI: \u22126.5, \u22122.5]; p &lt; 0.001), fat mass (\u22123.3 kg [\u22124.8, \u22121.9]; p &lt; 0.001), metabolic syndrome risk score (\u22120.19 [\u22120.32, \u22120.05]; p = 0.006), waist circumference (\u22123.2 cm [\u22125.5, \u22120.9]; p = 0.007), fasting plasma glucose (\u22120.23 mmol\/L [\u22120.44, \u22120.02]; p = 0.032), physical quality of life (2.7 [0.7, 4.6]; p = 0.007; Cohen\u2019s effect size (d) = 0.40), musculoskeletal pain (\u22120.5 [\u22120.8, \u22120.2]; p = 0.003; d = 0.49), and body image (\u22120.2 [\u22120.4, \u22120.0]; p = 0.030; d = 0.31) than usual care. At 18 months, effects on weight, adiposity, and metabolic syndrome risk scores were sustained; however, significant reductions in lean mass were observed (\u22121.1 kg [\u22121.7, \u22120.4]; p &lt; 0.001). This intervention led to sustained improvements in adiposity and metabolic syndrome risk.<\/jats:p>","DOI":"10.3390\/nu13114091","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T20:46:47Z","timestamp":1637009207000},"page":"4091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Effect of a Remotely Delivered Weight Loss Intervention in Early-Stage Breast Cancer: Randomized Controlled Trial"],"prefix":"10.3390","volume":"13","author":[{"given":"Marina M.","family":"Reeves","sequence":"first","affiliation":[{"name":"School of Public Health, The University of Queensland, Brisbane 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline O.","family":"Terranova","sequence":"additional","affiliation":[{"name":"School of Public Health, The University of Queensland, Brisbane 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A. H.","family":"Winkler","sequence":"additional","affiliation":[{"name":"School of Public Health, The University of Queensland, Brisbane 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Wesley Centre, Icon Cancer Care, Brisbane 4066, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-9165","authenticated-orcid":false,"given":"Ingrid J.","family":"Hickman","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Ware","sequence":"additional","affiliation":[{"name":"Menzies Health Institute Queensland, Griffith University, Brisbane 4111, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheleigh P.","family":"Lawler","sequence":"additional","affiliation":[{"name":"School of Public Health, The University of Queensland, Brisbane 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth G.","family":"Eakin","sequence":"additional","affiliation":[{"name":"School of Public Health, The University of Queensland, Brisbane 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5241-932X","authenticated-orcid":false,"given":"Wendy","family":"Demark-Wahnefried","sequence":"additional","affiliation":[{"name":"O\u2019Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.3322\/caac.21441","article-title":"Weight management and physical activity throughout the cancer care continuum","volume":"68","author":"Schmitz","year":"2018","journal-title":"CA Cancer J. 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