{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:32:56Z","timestamp":1760236376602,"version":"build-2065373602"},"reference-count":84,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1039 A03","CRC1080 C02","CRC1039 Z01"],"award-info":[{"award-number":["CRC1039 A03","CRC1080 C02","CRC1039 Z01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fraunhofer Cluster of Excellence for Immune Mediated diseases","award":["CIMD"],"award-info":[{"award-number":["CIMD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Progranulin deficiency in mice is associated with deregulations of the scavenger receptor signaling of CD36\/SCARB3 in immune disease models, and CD36 is a dominant receptor in taste bud cells in the tongue and contributes to the sensation of dietary fats. Progranulin-deficient mice (Grn\u2212\/\u2212) are moderately overweight during middle age. We therefore asked if there was a connection between progranulin\/CD36 in the tongue and fat taste preferences. By using unbiased behavioral analyses in IntelliCages and Phenomaster cages we showed that progranulin-deficient mice (Grn\u2212\/\u2212) developed a strong preference of fat taste in the form of 2% milk over 0.3% milk, and for diluted MCTs versus tap water. The fat preference in the 7d-IntelliCage observation period caused an increase of 10% in the body weight of Grn\u2212\/\u2212 mice, which did not occur in the wildtype controls. CD36 expression in taste buds was reduced in Grn\u2212\/\u2212 mice at RNA and histology levels. There were no differences in the plasma or tongue lipids of various classes including sphingolipids, ceramides and endocannabinoids. The data suggest that progranulin deficiency leads to a lower expression of CD36 in the tongue resulting in a stronger urge for fatty taste and fatty nutrition.<\/jats:p>","DOI":"10.3390\/nu13114125","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T09:16:11Z","timestamp":1637140571000},"page":"4125","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased Fat Taste Preference in Progranulin-Deficient Mice"],"prefix":"10.3390","volume":"13","author":[{"given":"Lana","family":"Schumann","sequence":"first","affiliation":[{"name":"Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annett","family":"Wilken-Schmitz","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Trautmann","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Vogel","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Hahnefeld","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Gurke","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Geisslinger","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt, Germany"},{"name":"Fraunhofer Cluster of Excellence for Immune Mediated Diseases (CIMD), 60596 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-8025","authenticated-orcid":false,"given":"Irmgard","family":"Tegeder","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.nbd.2016.09.010","article-title":"Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy","volume":"96","author":"Altmann","year":"2016","journal-title":"Neurobiol. 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