{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:44:07Z","timestamp":1788453847606,"version":"build-2803163510"},"reference-count":103,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The complementary feeding (CF) period that takes place between 6 and 24 months of age is of key importance for nutritional and developmental reasons during the transition from exclusively feeding on milk to family meals. In 2021, a multidisciplinary panel of experts from four Italian scientific pediatric societies elaborated a consensus document on CF, focusing in particular on healthy term infants. The aim was to provide healthcare providers with useful guidelines for clinical practice. Complementary feeding is also the time window when iron deficiency (ID) and iron deficiency anemia (IDA) are most prevalent. Thus, it is appropriate to address the problem of iron deficiency through nutritional interventions. Adequate iron intake during the first two years is critical since rapid growth in that period increases iron requirements per kilogram more than at any other developmental stage. Complementary foods should be introduced at around six months of age, taking into account infant iron status.<\/jats:p>","DOI":"10.3390\/nu13124201","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T23:22:56Z","timestamp":1638314576000},"page":"4201","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Complementary Feeding and Iron Status: \u201cThe Unbearable Lightness of Being\u201d Infants"],"prefix":"10.3390","volume":"13","author":[{"given":"Vito Leonardo","family":"Miniello","sequence":"first","affiliation":[{"name":"Nutrition Unit, Department of Pediatrics, \u201cGiovanni XXIII\u201d Children Hospital, \u201cAldo Moro\u201d University of Bari, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmen","family":"Verga","sequence":"additional","affiliation":[{"name":"Primary Care Pediatrics, ASL Salerno, 84019 Vietri sul Mare, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Miniello","sequence":"additional","affiliation":[{"name":"Department of Allergology and Immunology, \u201cAldo Moro\u201d University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Di Mauro","sequence":"additional","affiliation":[{"name":"Regional Centre of Pharmacovigilance Campania, Department of Experimental Medicine, University \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Diaferio","sequence":"additional","affiliation":[{"name":"Giovanni XXIII\u201d Children Hospital, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-974X","authenticated-orcid":false,"given":"Ruggiero","family":"Francavilla","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Pediatrics, \u201cGiovanni XXIII\u201d Children Hospital, \u201cAldo Moro\u201d University of Bari, 70126 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2019). Thirteenth General Programme of Work 2019\u20132023. Promote Health. Keep the World Safe. Serve the Vulnerable, World Health Organization. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/324775\/WHO-PRP-18.1-eng.pdf."},{"key":"ref_2","unstructured":"World Health Organization (2015). The Minsk Declaration: The Life-Course Approach in the Context of Health 2020, WHO."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"574111","DOI":"10.3389\/fpubh.2020.574111","article-title":"Management and prevention strategies for non-communicable diseases (N.C.D.s) and their risk factors","volume":"8","author":"Budreviciute","year":"2020","journal-title":"Front. Public Health"},{"key":"ref_4","unstructured":"World Health Organization (2020, January 13). Global Action Plan: For the Prevention and Control of Non-Communicable Diseases. (2013\u20132020). Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/94384\/9789241506236_eng.pdf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0140-6736(13)60996-4","article-title":"Evidence-based interventions for improvement of maternal and child nutrition: What can be done and at what cost?","volume":"382","author":"Bhutta","year":"2013","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fnhum.2013.00585","article-title":"Perinatal iron deficiency and neurocognitive development","volume":"7","author":"Radlowski","year":"2013","journal-title":"Front. Hum. Neurosci."},{"key":"ref_7","first-page":"CD001444","article-title":"Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia","volume":"6","author":"Wang","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1542\/peds.2010-2576","article-title":"Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0\u20133 years of age)","volume":"126","author":"Baker","year":"2010","journal-title":"Pediatrics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100866","DOI":"10.1016\/j.blre.2021.100866","article-title":"The critical roles of iron during the journey from fetus to adolescent: Developmental aspects of iron homeostasis","volume":"50","author":"Donker","year":"2021","journal-title":"Blood Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2016.12.034","article-title":"A red carpet for iron metabolism","volume":"168","author":"Muckenthaler","year":"2017","journal-title":"Cell"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"Pearce","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fmolb.2019.00116","article-title":"The Role of Iron Regulation in Immunometabolism and Immune-Related Disease","volume":"6","author":"Cronin","year":"2019","journal-title":"Front. Mol. Biosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e4092","DOI":"10.1002\/nbm.4092","article-title":"The role of iron and myelin in orientation dependent R2* of white matter","volume":"32","author":"Kor","year":"2019","journal-title":"NMR Biomed."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: Past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_15","unstructured":"Makrides, M. (2020, November 22). Ann. Nestl\u00e9, Available online: https:\/\/www.nestlenutrition-institute.org\/sites\/default\/files\/documents-library\/publications\/secured\/947821251fd3c5fa0ff8981c511c5d1d.pdf."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e884","DOI":"10.1542\/peds.2009-3535","article-title":"Home intervention improves cognitive and social-emotional scores in iron-deficient anemic infants","volume":"126","author":"Lozoff","year":"2010","journal-title":"Pediatrics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3389\/fimmu.2020.01313","article-title":"Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants","volume":"11","author":"Stoffel","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"PAHO\/WHO (2012). Guiding principles for complementary feeding of the breastfed child. Washington, DC: Pan American Health Organization, World Health Organization, 2003. Section on B. breastfeeding and the use of human milk. Pediatrics, 129, e827\u2013e841.","DOI":"10.1542\/peds.2011-3552"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/MPG.0000000000000206","article-title":"Iron requirements of infants and toddlers","volume":"58","author":"Domellof","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_20","unstructured":"Health Canada, Canadian Paediatric Society, Dietitians of Canada, and Breastfeeding Committee for Canada (2019, June 18). Nutrition for Healthy Term Infants: Recommendations from Six to 24 Months. Available online: https:\/\/www.canada.ca\/en\/health-canada\/services\/canada-food-guide\/resources\/infant-feeding\/nutrition-healthy-term-infants-recommendations-birth-six-months\/6-24-months.html."},{"key":"ref_21","first-page":"1","article-title":"Documento Intersocietario Raccomandazioni sull\u2019Alimentazione Complementare, strumento per la prevenzione delle malattie croniche non trasmissibili e per la riduzione delle ineguaglianze sociali","volume":"3","author":"Miniello","year":"2021","journal-title":"Pediatr. Prev. Soc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/MPG.0000000000001454","article-title":"Complementary Feeding: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition(ESPGHAN) Committee on Nutrition","volume":"64","author":"Fewtrell","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ferreira, A., Neves, P., and Gozzelino, R. (2019). Multilevel Impacts of Iron in the Brain: The Cross Talk between Neurophysiological Mechanisms, Cognition, and Social Behavior. Pharmaceuticals, 12.","DOI":"10.3390\/ph12030126"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jpeds.2019.05.030","article-title":"Randomized Controlled Trial of Iron-Fortified versus Low-Iron Infant Formula: Developmental Outcomes at 16 Years","volume":"212","author":"Gahagan","year":"2019","journal-title":"J. Pediatr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/nutrit\/nux015","article-title":"Impact of High Iron Intake on Cognition and Neurodegeneration in Humans and in Animal Models: A Systematic Review","volume":"75","author":"Agrawal","year":"2017","journal-title":"Nutr. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/tropej\/49.2.84","article-title":"The Effect of Iron Therapy on the Growth of Iron-Replete and Iron-Deplete Children","volume":"49","author":"Majumdar","year":"2003","journal-title":"J. Trop. Pediatr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nrneurol.2015.100","article-title":"Is early-life iron exposure critical in neurodegeneration?","volume":"11","author":"Hare","year":"2015","journal-title":"Nat. Rev. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1093\/jn\/132.11.3249","article-title":"Iron supplementation affects growth and morbidity of breastfed infants: Results of a randomized trial in Sweden and Honduras","volume":"132","author":"Dewey","year":"2002","journal-title":"J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10534-018-0126-2","article-title":"Oxidative Stress and Neurodegeneration: The Involvement of Iron","volume":"31","author":"Carocci","year":"2018","journal-title":"Biometals"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/jn\/nxy227","article-title":"Iron Oversupplementation Causes Hippocampal Iron Overloading and Impairs Social Novelty Recognition in Nursing Piglets","volume":"149","author":"Ji","year":"2019","journal-title":"J. Nutr."},{"key":"ref_31","first-page":"1748354","article-title":"Delivery mode and perinatal antibiotics influence the predicted metabolic pathways of the gut microbiome","volume":"11","author":"Tejesvi","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Paganini, D., Uyoga, M.A., and Zimmermann, M.B. (2016). Iron Fortification of Foods for Infants and Children in Low-Income Countries: Effects on the Gut Microbiome, Gut Inflammation, and Diarrhea. Nutrients, 8.","DOI":"10.3390\/nu8080494"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/gutjnl-2014-307720","article-title":"Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants","volume":"64","author":"Jaeggi","year":"2015","journal-title":"Gut"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cca.2015.01.022","article-title":"Gut microbiota biomodulators, when the stork comes by the scalpel","volume":"451","author":"Miniello","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0140-6736(15)60865-0","article-title":"Iron deficiency anaemia","volume":"387","author":"Lopez","year":"2016","journal-title":"Lancet"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJMra1401038","article-title":"Iron-deficiency anemia","volume":"373","author":"Camaschella","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Gupta, P.M., Perrine, C.G., Mei, Z., and Scanlon, K.S. (2016). Iron, Anemia, and Iron Deficiency Anemia among Young Children in the United States. Nutrients, 8.","DOI":"10.3390\/nu8060330"},{"key":"ref_38","unstructured":"Dahlerup, J., Lindgren, S., and Moum, B. (2015). Iron deficiency and iron deficiency anemia are global health problems. Lakartidningen, 112, PubMed 25756711."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/bfm.2007.0002","article-title":"Full breastfeeding duration and risk for iron deficiency in U.S. infants","volume":"2","author":"Chantry","year":"2007","journal-title":"Breastfeed. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1111\/j.1753-4887.2011.00431.x","article-title":"Consumption cow\u2019s milk as a cause of iron deficiency in infants and toddlers","volume":"69","author":"Ziegler","year":"2011","journal-title":"Nutr. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s00394-012-0472-8","article-title":"Iron status of one-year-olds and association with breast milk, cow\u2019s milk or formula in late infancy","volume":"52","author":"Thorisdottir","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1017\/S1368980000000501","article-title":"Risk factors for poor iron status in British toddlers: Further analysis of data from the National Diet and Nutrition Survey of children aged 1.5\u20134.5 years","volume":"3","author":"Thane","year":"2000","journal-title":"Public Health Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.siny.2006.10.007","article-title":"Iron in fetal and neonatal nutrition","volume":"12","author":"Rao","year":"2007","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000480741","article-title":"Meeting the iron needs of low and very low birth weight infants","volume":"71","author":"Domellof","year":"2017","journal-title":"Ann. Nutr. Metab."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wawer, A.A., Hodyl, N.A., Fairweather-Tait, S., and Froessler, B. (2021). Are Pregnant Women Who Are Living with Overweight or Obesity at Greater Risk of Developing Iron Deficiency Anaemia?. Nutrients, 13.","DOI":"10.3390\/nu13051572"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Dumrongwongsiri, O., Winichagoon, P., Chongviriyaphan, N., Suthutvoravut, U., Grote, V., and Koletzko, B. (2021). Effect of Maternal Nutritional Status and Mode of Delivery on Zinc and Iron Stores at Birth. Nutrients, 13.","DOI":"10.3390\/nu13030860"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"d7157","DOI":"10.1136\/bmj.d7157","article-title":"Effect of delayed versus early umbilical cord clamping on neonatal outcomes and iron status at 4 months: A randomized controlled trial","volume":"343","author":"Andersson","year":"2011","journal-title":"BMJ"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/ajcn\/nqy267","article-title":"Timing of introduction of complementary foods and beverages and growth, size, and body composition: A systematic review","volume":"109","author":"English","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_49","unstructured":"United States Department of Agriculture (2020, November 22). Scientific Report of the 2020 Dietary Guidelines Advisory Committee, Available online: https:\/\/www.dietaryguidelines.gov\/sites\/default\/files\/2020-07\/ScientificReport_of_the_2020DietaryGuidelinesAdvisoryCommittee_first-print.pdf."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Dewey, K., and Harrison, M. (2020). Feeding Infants and Children from Birth to 24 Months: Summarizing Existing Guidance, National Institutes of Health. The National Academies Collection.","DOI":"10.17226\/25747"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/01.mpg.0000187817.38836.42","article-title":"Global standard for the composition of infant formula: Recommendations of an ESPGHAN coordinated international expert group","volume":"41","author":"Koletzko","year":"2005","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0022-3476(98)70352-X","article-title":"Prevention of iron-deficiency anemia: Comparison of high- and low-iron formulas in term healthy infants after six months of life","volume":"132","author":"Walter","year":"1998","journal-title":"J. Pediatr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e00036-17","DOI":"10.1128\/MMBR.00036-17","article-title":"The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota","volume":"81","author":"Milani","year":"2017","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrgastro.2012.156","article-title":"The role of the gut microbiota in nutrition and health","volume":"9","author":"Flint","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.chom.2012.10.012","article-title":"Defining a healthy human gut microbiome: Current concepts, future directions, and clinical applications","volume":"12","author":"Backhed","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1353\/pbm.1997.0072","article-title":"The Lactobacillus anomaly: Total iron abstinence","volume":"40","author":"Weinberg","year":"1997","journal-title":"Perspect. Biol. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1001\/jama.2013.277129","article-title":"Effect of iron fortification on malaria incidence in infants and young children in Ghana: A randomized trial","volume":"310","author":"Zlotkin","year":"2013","journal-title":"JAMA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(13)60437-7","article-title":"Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: A cluster-randomized trial","volume":"382","author":"Soofi","year":"2013","journal-title":"Lancet"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e12444","DOI":"10.1111\/mcn.12444","article-title":"Emerging issues in complementary feeding: Global aspects","volume":"13","author":"Michaelsen","year":"2017","journal-title":"Matern. Child Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fimmu.2021.578386","article-title":"Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body","volume":"12","author":"Cristofori","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1126\/science.aad9378","article-title":"How colonization by microbiota in early life shapes the immune system","volume":"352","author":"Gensollen","year":"2016","journal-title":"Science"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions: Metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_63","first-page":"253","article-title":"Iron and prebiotic fortified flour improves the immune function of iron deficient women of childbearing age","volume":"33","author":"Ahmad","year":"2020","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00394-016-1353-3","article-title":"In vitro assessment of iron availability from commercial Young Child Formulae supplemented with prebiotics","volume":"57","author":"Christides","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/1471-0307.12575","article-title":"Iron fortification of reduced-fat bioyoghurt containing either short-or long-chain inulin","volume":"72","author":"Dabour","year":"2019","journal-title":"Int. J. Dairy Technol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ferus, K., Drabinska, N., Krupa-Kozak, U., and Jarocka-Cyrta, E. (2018). A randomized, placebo-controlled, pilot clinical trial to evaluate the effect of supplementation with prebiotic Synergy 1 on iron homeostasis in children and adolescents with celiac disease treated with a gluten-free diet. Nutrients, 10.","DOI":"10.3390\/nu10111818"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.colsurfb.2019.04.049","article-title":"Pectin-decorated magnetite nanoparticles as both iron delivery systems and protective matrices for probiotic bacteria","volume":"180","author":"Ghibaudo","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/jn\/nxy327","article-title":"Consumption of galacto-oligosaccharides increases iron absorption from ferrous fumarate: A stable iron isotope study in iron-depleted young women","volume":"149","author":"Jeroense","year":"2019","journal-title":"J. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Paganini, D., Uyoga, M.A., Kortman, G.A., Boekhorst, J., Schneeberger, S., Karanja, S., Hennet, T., and Zimmermann, M.B. (2019). Maternal Human Milk Oligosaccharide Profile Modulates the Impact of an Intervention with Iron and Galacto-Oligosaccharides in Kenyan Infants. Nutrients, 11.","DOI":"10.3390\/nu11112596"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1039\/C6FO01833E","article-title":"Prebiotics increase heme iron bioavailability and do not affect non-heme iron bioavailability in humans","volume":"8","author":"Weinborn","year":"2017","journal-title":"Food Funct."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Vonderheid, S.C., Tussing-Humphreys, L., Park, C., Pauls, H., Hemphill, N.O.N., LaBomascus, B., McLeod, A., and Koenig, M.D. (2019). A Systematic Review and Meta-Analysis on the Effects of Probiotic Species on Iron Absorption and Iron Status. Nutrients, 11.","DOI":"10.3390\/nu11122938"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.crfs.2021.08.001","article-title":"Physicochemical properties of human breast milk during the second year of lactation","volume":"4","author":"Fatouros","year":"2021","journal-title":"Curr. Res. Food Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1017\/S0007114518000120","article-title":"Infant formulae supplemented with prebiotics: Are they better than unsupplemented formulae? An updated systematic review","volume":"119","author":"Szajewska","year":"2018","journal-title":"Br. J. Nutr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.3945\/jn.116.236919","article-title":"Similar to Those Who Are Breastfed, Infants Fed a Formula Containing 2\u2019-Fucosyllactose have Lower Inflammatory Cytokines in a Randomized Controlled Trial","volume":"146","author":"Goehring","year":"2016","journal-title":"J. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/MPG.0000000000001520","article-title":"Effects of Infant Formula With Human Milk Oligosaccharides on Growth and Morbidity: A Randomized Multicenter Trial","volume":"64","author":"Puccio","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1017\/S0007114512004229","article-title":"Immunological programming by breast milk creates an anti-inflammatory cytokine milieu in breastfed infants compared to formula-fed infants","volume":"109","author":"Kainonen","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/MPG.0000000000000889","article-title":"Infants Fed a Lower Calorie Formula with 2\u2019FL Show Growth and 2\u2019FL Uptake Like Breast-Fed Infants","volume":"61","author":"Marriage","year":"2015","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e046370","DOI":"10.1136\/bmjopen-2020-046370","article-title":"Effect of consumption of animal milk compared to infant formula for non-breastfed\/mixed-fed infants 6-11 months of age: A systematic review","volume":"11","author":"Imdad","year":"2021","journal-title":"BMJ Open"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Tang, M. (2018). Protein Intake during the First Two Years of Life and Its Association with Growth and Risk of Overweight. Int. J. Environ. Res. Public Health, 15.","DOI":"10.3390\/ijerph15081742"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000486495","article-title":"Complementary Feeding, Infant Growth, and Obesity Risk: Timing, Composition, and Mode of Feeding","volume":"89","author":"Grote","year":"2018","journal-title":"Nestle Nutr. Inst. Workshop Ser."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Martin, C.R., Ling, P.R., and Blackburn, G.L. (2016). Review of infant feeding: Key features of breast milk and infant formula. Nutrients, 8.","DOI":"10.3390\/nu8050279"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"718S","DOI":"10.3945\/ajcn.113.072603","article-title":"Protein needs early in life and long-term health","volume":"99","author":"Michaelsen","year":"2014","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/07315724.2018.1491016","article-title":"Cow\u2019s Milk Consumption and Health: A Health Professional\u2019s Guide","volume":"38","author":"Marangoni","year":"2019","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3945\/an.116.013953","article-title":"Systematic Review of the Gastrointestinal Effects of A1 Compared with A2 \u03b2-Casein","volume":"8","author":"Dwyer","year":"2017","journal-title":"Adv. Nutr."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1080\/10408398.2019.1707157","article-title":"Occurrence, biological properties and potential effects on human health of \u03b2-casomorphin 7: Current knowledge and concerns","volume":"60","author":"Summer","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3945\/ajcn.115.128009","article-title":"High protein intake in young children and increased weight gain and obesity risk","volume":"103","author":"Koletzko","year":"2016","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1017\/S1368980015001354","article-title":"Health effects of cow\u2019s milk consumption in infants up to 3 years of age: A systematic review and meta-analysis","volume":"19","author":"Griebler","year":"2015","journal-title":"Public Health Nutr."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/0379572119885482","article-title":"Dietary Iron Bioavailability: A Simple Model That Can Be Used to Derive Country-Specific Values for Adult Men and Women","volume":"41","author":"Speich","year":"2020","journal-title":"Food Nutr. Bull."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ajcn\/nqy038","article-title":"A meat- or dairy-based complementary diet leads to distinct growth patterns in formula-fed infants: A randomized controlled trial","volume":"107","author":"Tang","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jpeds.2020.10.071","article-title":"A Substantial Proportion of 6- to 12-Month-Old Infants Have Calculated Daily Absorbed Iron below Recommendations, Especially Those Who Are Breast-fed","volume":"231","author":"Abrams","year":"2021","journal-title":"J. Pediatr."},{"key":"ref_92","unstructured":"Food and Nutrition Board, Institute of Medicine (2001). Dietary Reference Intakes for Vitamin A, Vitamin K, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadiumand Zinc, National Academy Press."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1516S","DOI":"10.1093\/jn\/nxy035","article-title":"The Feeding Infants and Toddlers Study (FITS) 2016: Study design and methods","volume":"148","author":"Anater","year":"2018","journal-title":"J. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jpeds.2020.12.011","article-title":"Are Breastfed Infants Iron Deficient? The Question That Won\u2019t Go Away","volume":"231","author":"Greer","year":"2021","journal-title":"J. Pediatr."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/jhn.12452","article-title":"Nutrient intakes and compliance with nutrient recommendations in children aged 1\u20134 years in Ireland","volume":"30","author":"Walton","year":"2017","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s00394-015-0978-y","article-title":"Energy and macronutrient intakes and adherence to dietary guidelines of infants and toddlers in Belgium","volume":"55","author":"Huysentruyt","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2013). Scientific Opinion on nutrient requirements and dietary intakes of infants and young children in the European Union. EFSA J., 11, 3408.","DOI":"10.2903\/j.efsa.2013.3408"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000438495","article-title":"Composition of follow-up formula for young children aged 12\u201336 months: Recommendations of an International Expert Group Coordinated by the Nutrition Association of Thailand and the Early Nutrition Academy","volume":"67","author":"Suthutvoravut","year":"2015","journal-title":"Ann. Nutr. Metab."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Ferr\u00e9, N., Luque, V., Closa-Monasterolo, R., Zaragoza-Jordana, M., Gispert-Llaurad\u00f3, M., Grote, V., Koletzko, B., and Escribano, J. (2021). Association of Protein Intake during the Second Year of Life with Weight Gain-Related Outcomes in Childhood: A Systematic Review. Nutrients, 13.","DOI":"10.3390\/nu13020583"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/MPG.0000000000001821","article-title":"Young child formula: A position paper by the ESPGHAN committee on nutrition","volume":"66","author":"Hojsak","year":"2018","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1017\/jns.2016.24","article-title":"Nutrient intakes and iron and vitamin D status differ depending on main milk consumed by U.K. children aged 12\u201318 months\u2014Secondary analysis from the Diet and Nutrition Survey of Infants and Young Children","volume":"5","author":"Sidnell","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3945\/ajcn.116.136143","article-title":"A micronutrient-fortified young-child formula improves the iron and vitamin D status of healthy young European children: A randomized, double-blind controlled trial","volume":"105","author":"Akkermans","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Lovell, A.L., Milne, T., Jiang, Y., Chen, R.X., Grant, C.C., and Wall, C.R. (2019). Evaluation of the effect of a growing up milk lite vcow\u2019sw\u2019s milk on diet quality and dietary intakes in early childhood: The Growing Up Milk Lite (GUMLi) randomized controlled trial. Nutrients, 11.","DOI":"10.3390\/nu11010203"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/12\/4201\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:34:51Z","timestamp":1760168091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/13\/12\/4201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":103,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["nu13124201"],"URL":"https:\/\/doi.org\/10.3390\/nu13124201","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,23]]}}}